Detailed view for Rv2754c

Basic information

TDR Targets ID: 980790
Mycobacterium tuberculosis, Probable thymidylate synthase ThyX (ts) (TSase)

Source Database / ID:  Tuberculist 

pI: 6.9681 | Length (AA): 250 | MW (Da): 27559 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 247 3gwc (A) 2 247 99.99 0 1 2.1722 -0.95

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_136913)

Species Accession Gene Product
Mycobacterium leprae ML1514c   PROBABLE THYMIDYLATE SYNTHASE THYX (TS) (TSase)
Mycobacterium tuberculosis Rv2754c   Probable thymidylate synthase ThyX (ts) (TSase)
Mycobacterium ulcerans MUL_2183   FAD-dependent thymidylate synthase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

Compound Source Reference
References
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Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Paramecium bursaria Chlorella virus 1 Probable thymidylate synthase 216 aa 27.5% 200 aa Compounds References

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.2309 0.7533 0.8013
0.1686 0.2939 0.3054
0.1336 0.4096 0
0.3455 0.2762 0.2761
0.7601 1 1
0.1598 0.4624 0.4611
0.3634 0.337 0.337
0.352 0.5873 1
0.1698 0.4102 0.4023
0.189 0.7263 0.7263
0.1801 0.3133 0.3282
0.1569 0.6097 0.6093
0.1644 1 1
0.5049 1 1
0.1303 0.8406 0.84
0.1033 1 1
0.1136 1 1
0.1303 0.9524 0.9504
1.0048 1 1
0.1758 0.4105 0.4105
0.631 0.842 0.8703
0.179 0.5144 0.8822
0.976 0.9793 1
0.1689 1 1
0.1235 0.669 0.9536
0.1085 1 1
0.1618 1 1
0.108 0.6412 0.6412
0.1958 1 1
0.1755 0.3017 0.9388
0.1239 0.7457 0.7449
0.4474 0.449 1
0.1787 0.9088 1
0.4474 0.449 1
0.4652 1 1
0.2896 0.4165 0.4165
0.6588 1 1
0.179 0.3197 0.3288
0.1851 0.7648 0.7648
0.1336 0.4096 0
0.5723 0.6707 0.8703
0.7353 1 1
0.6588 1 1
0.1606 1 1
0.3455 0.2762 0.2761
0.1303 0.9524 0.9504
0.1577 0.4611 0.4611
0.0604 0.2642 0.5041
0.1877 0.6038 0.6038
0.1218 0.6 0.7453
0.1715 1 1
0.5583 1 1
0.1802 0.777 0.777
0.1598 0.4624 0.4611
0.1667 0.3641 0.3814
0.5137 0.8076 0.8419
1.0048 1 1
0.3557 0.719 1
0.6282 0.5299 1
0.1628 1 1
1.0801 1 0.5
0.3455 0.2763 0.2763
0.1715 1 1
0.3189 0.5088 0.4947
0.6659 0.5915 1
0.1599 1 1
0.2896 0.4165 0.4165
1.1302 0.9793 1
0.4437 1 1
0.1755 0.3017 0.9388
0.1065 0.4311 1
0.631 0.842 0.8703
0.1766 0.9569 0.9569
0.1835 0.3186 0.3324
0.1628 1 1
0.8579 1 1
0.1946 0.9108 1
0.7119 1 1
0.1235 0.669 0.9536
0.7996 1 1
0.5243 1 1
0.4473 0.6845 1
0.4036 0.3063 0.8005
0.1144 0.3181 0.6848
0.5063 1 1
0.1569 0.6097 0.6093
0.1177 0.669 0.9536
0.6236 1 1
0.1686 0.286 0.2968
0.1031 0.5119 0.9536
0.1814 0.6542 0.6542
0.1303 0.7457 0.7449
0.1571 1 1
0.8989 1 1
0.9043 1 1
0.1598 0.4624 0.4611
0.163 1 1
0.1218 0.6863 0.6839
0.6477 1 1
0.9043 1 1
0.6533 1 1
0.1958 1 1
0.1662 1 1
0.1877 0.6086 0.6074
0.4398 0.3335 0.7712
0.1877 0.6086 0.6074
0.5019 0.5254 0.5469
0.5893 1 1
0.1617 1 1
1.0989 0.5 0.5
0.179 0.5144 0.8822
1.1228 1 1
0.1643 0.337 0.3563
0.3634 0.337 0.337
0.2896 0.4165 0.4165
1.0111 1 1
0.1598 0.4624 0.4611
0.3268 1 1
0.1283 0.4146 0.4142
0.3226 1 1
0.1958 1 0.5
0.7099 0.8659 1
0.5209 0.8076 0.8419
0.7153 1 1
0.1877 0.6086 0.6074
0.1958 1 1
0.1026 1 1
0.7663 1 1
0.2896 0.4165 0.4165
0.3634 0.337 0.337
0.6588 1 1
0.107 0.6384 0.6364
0.5079 1 1
0.1717 0.4261 0.4258
0.3594 0.5657 0.8243
0.6588 1 1
0.1726 1 1
0.1618 1 1
1.1302 1 1
0.4846 0.5363 0.5519
0.961127 1 1
0.2896 0.4165 0.4165
1.0801 1 0.5
0.4398 0.3335 0.7712
0.5243 1 1
0.7146 1 1
0.1592 0.509 0.5064
0.4108 0.8012 0.8418
0.1711 1 1
0.7664 0.97 1
0.1626 0.2973 1
0.4763 0.5904 0.6094
0.6492 1 1
0.1643 0.337 0.3563
0.1958 1 1
0.3177 0.4025 0.4158
0.1577 0.3699 0.3594
0.1946 0.9108 1
0.1567 1 1
0.1569 0.6097 0.6093
0.1717 0.4259 0
0.5723 0.6707 0.8703
0.1958 1 1
0.1946 0.4385 0.4385
0.1303 0.9524 0.9504
0.7099 0.5915 1
0.1877 0.6086 0.6074
1.1228 1 1
0.1587 0.3549 0.3769
0.9609 1 1
0.1569 0.2502 0.2618
0.1643 0.337 0.3563
0.5029 1 1
0.1144 0.639 0.6364
0.1715 1 1
1.0111 1 1
0.6946 1 1
0.1644 1 1
0.1136 1 1
0.2532 0.2652 0.2667
0.1655 1 1
0.7099 0.8659 1
0.4036 0.3063 0.8005
0.7099 0.8659 1
0.1577 0.4611 0.4611
0.1717 0.4261 0.4258
0.2896 0.4165 0.4165
0.4622 0.8075 0.8418
0.352 0.5873 1
0.1151 0.4157 0
0.631 0.842 0.8703
0.5019 0.5254 0.5469
0.9052 1 1
0.1144 0.3181 0.6848
0.4036 0.3063 0.8005
0.348 1 1
0.215872 1 1
0.649 1 1
0.4917 0.5171 0.536
0.1755 0.3017 0.9388
0.4652 1 1
0.1567 1 1
0.1133 0.6875 0.6866
0.1715 1 1
0.5283 0.8075 0.8417
0.1679 0.5908 0.5896
0.7099 0.8659 1
0.4824 0.5243 0.5388
0.1715 1 1
0.9609 1 1
0.1755 0.3017 0.9388
0.6236 1 1
0.8792 1 1
0.1589 1 1
0.1626 0.2973 1
0.3177 0.4025 0.4158
1.0111 1 1
0.6588 1 1
0.1577 0.3699 0.3594
1.0715 0.9793 1
0.7601 1 1
0.6672 1 1
0.1283 0.4146 0.4142
0.7224 1 1
0.1638 1 1
0.17 1 1
0.3601 1 0.5
0.1689 1 1
0.2309 0.7533 0.8013
0.5019 0.5254 0.5469
0.4652 1 1
0.4822 0.5901 0.6059
0.9024 1 1
0.5209 0.8076 0.8419
0.1065 0.4311 1
0.1717 0.4261 0.4258
0.1632 0.3953 0.4175
0.1958 0.2519 1
0.7601 1 1

Assayability

Assay information

  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis ThyX-mediated dTMP synthesis using [5-3H]dUMP as substrate at 50 uM after 10 mins by liquid scintillation counting
  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis ThyX-mediated dTMP synthesis using [5-3H]dUMP as substrate after 10 mins by liquid scintillation counting

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Rv2754c (Mycobacterium tuberculosis), Probable thymidylate synthase ThyX (ts) (TSase)
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