Detailed view for Rv1551

Basic information

TDR Targets ID: 980825
Mycobacterium tuberculosis, Possible acyltransferase PlsB1

Source Database / ID:  Tuberculist 

pI: 6.454 | Length (AA): 621 | MW (Da): 69192 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

Gene Ontology

Mouse over links to read term descriptions.
GO:0044255   cellular lipid metabolic process  
GO:0016746   transferase activity, transferring acyl groups  
GO:0008374   O-acyltransferase activity  
GO:0005886   plasma membrane  
GO:0004366   glycerol-3-phosphate O-acyltransferase activity  
GO:0008152   metabolic process  
GO:0008654   phospholipid biosynthetic process  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
215 411 4gyp (C) 146 342 30.00 0.019 0.89 0.33613 1.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129498)

Species Accession Gene Product
Brugia malayi Bm1_40215   Acyltransferase family protein
Candida albicans CaO19.4066   C terminus is same as nonallelic CaP19.196
Candida albicans CaO19.7826   end of contig orf same as C terminus of nonallelic CaP19.4066 potential acyltransferase
Candida albicans CaO19.11549   C terminus is same as nonallelic CaP19.196
Candida albicans CaO19.196   end of contig orf same as C terminus of nonallelic CaP19.4066 potential acyltransferase
Caenorhabditis elegans CELE_Y46G5A.21   Protein ACL-7
Drosophila melanogaster Dmel_CG4625   Dihydroxyacetone phosphate acyltransferase
Escherichia coli b4041   glycerol-3-phosphate O-acyltransferase
Homo sapiens ENSG00000116906   glyceronephosphate O-acyltransferase
Leishmania braziliensis LbrM.20.1120   dihydroxyacetonephosphate acyltransferase;with=GeneDB:LmjF34.1090
Leishmania donovani LdBPK_341170.1   dihydroxyacetone phosphate acyltransferase, putative
Leishmania infantum LinJ.34.1170   dihydroxyacetonephosphate acyltransferase;with=GeneDB:LmjF34.1090
Leishmania major LmjF.34.1090   dihydroxyacetonephosphate acyltransferase
Leishmania mexicana LmxM.33.1090   dihydroxyacetonephosphate acetyltransferase
Loa Loa (eye worm) LOAG_00301   hypothetical protein
Mycobacterium leprae ML1246   PROBABLE GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE PLSB2 (GPAT)
Mus musculus ENSMUSG00000031985   glyceronephosphate O-acyltransferase
Mycobacterium tuberculosis Rv2482c   Probable glycerol-3-phosphate acyltransferase PlsB2 (GPAT)
Mycobacterium tuberculosis Rv1551   Possible acyltransferase PlsB1
Mycobacterium ulcerans MUL_1547   glycerol-3-phosphate acyltransferase
Schmidtea mediterranea mk4.000360.09   Dihydroxyacetone phosphate acyltransferase
Schmidtea mediterranea mk4.000360.08   Dihydroxyacetone phosphate acyltransferase
Trypanosoma brucei gambiense Tbg972.4.3170   dihydroxyacetone phosphate acyltransferase, putative,glycerol-3-phosphate acyltransferase, putative
Trypanosoma brucei Tb927.4.3160   dihydroxyacetone phosphate acyltransferase, putative
Trypanosoma cruzi TcCLB.506435.270   dihydroxyacetone phosphate acyltransferase, putative
Trypanosoma cruzi TcCLB.504055.40   dihydroxyacetone phosphate acyltransferase, putative
Toxoplasma gondii TGME49_221518   hypothetical protein
Toxoplasma gondii TGME49_203570   acyltransferase domain-containing protein

Essentiality

Rv1551 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.3160 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.3160 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.3160 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.4.3160 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b4041 Escherichia coli essential goodall
TGME49_221518 Toxoplasma gondii Probably non-essential sidik
TGME49_203570 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens glyceronephosphate O-acyltransferase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0006 0.5 0.5
0.0006 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Rv1551 (Mycobacterium tuberculosis), Possible acyltransferase PlsB1
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