pI: 4.4183 |
Length (AA): 291 |
MW (Da): 30273 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
19 | 279 | 3mka (C) | 0 | 522 | 99.99 | 0 | 1 | 2.00851 | -0.62 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127100)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G13060 | 20S proteasome beta subunit E1 |
Arabidopsis thaliana | AT3G26340 | proteasome subunit beta type-5-B |
Babesia bovis | BBOV_IV009000 | proteasome epsilon subunit, putative |
Brugia malayi | Bm1_55200 | Proteasome A-type and B-type family protein |
Candida albicans | CaO19.9775 | proteasome subunit |
Candida albicans | CaO19.2233 | proteasome subunit |
Caenorhabditis elegans | CELE_K05C4.1 | Protein PBS-5 |
Cryptosporidium hominis | Chro.50424 | hypothetical protein |
Cryptosporidium parvum | cgd5_4210 | Pre2p/proteasome subunit beta type 5; NTN hydrolase fold |
Dictyostelium discoideum | DDB_G0293784 | 20S proteasome subunit beta-5 |
Drosophila melanogaster | Dmel_CG12323 | Proteasome beta5 subunit |
Drosophila melanogaster | Dmel_CG9868 | Proteasome beta5 subunit-related 1 |
Drosophila melanogaster | Dmel_CG31742 | Proteasome beta5 subunit-related 2 |
Drosophila melanogaster | Dmel_CG18341 | Proteasome beta2 subunit-related 1 |
Echinococcus granulosus | EgrG_000590200 | proteasome prosome macropain |
Entamoeba histolytica | EHI_011870 | proteasome subunit beta type 5 precursor, putative |
Echinococcus multilocularis | EmuJ_000590200 | proteasome (prosome, macropain) |
Giardia lamblia | GL50803_12949 | Proteasome subunit beta type 5 precursor |
Homo sapiens | ENSG00000100804 | proteasome (prosome, macropain) subunit, beta type, 5 |
Homo sapiens | ENSG00000204264 | proteasome (prosome, macropain) subunit, beta type, 8 |
Leishmania braziliensis | LbrM.35.1840 | proteasome beta 5 subunit, putative |
Leishmania donovani | LdBPK_361730.1 | proteasome subunit beta type-5, putative |
Leishmania infantum | LinJ.36.1730 | proteasome beta 5 subunit, putative |
Leishmania major | LmjF.36.1650 | proteasome beta 5 subunit, putative |
Leishmania mexicana | LmxM.36.1650 | proteasome beta 5 subunit, putative |
Loa Loa (eye worm) | LOAG_04838 | proteasome A-type and B-type family protein |
Mycobacterium leprae | ML1322 | proteasome (beta subunit) PrcB |
Mus musculus | 16913 | proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) |
Mus musculus | ENSMUSG00000022193 | proteasome (prosome, macropain) subunit, beta type 5 |
Mycobacterium tuberculosis | Rv2110c | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. |
Mycobacterium ulcerans | MUL_2331 | proteasome PrcB |
Neospora caninum | NCLIV_061460 | Family T1, proteasome beta subunit, threonine peptidase, related |
Oryza sativa | 4340166 | Os06g0153800 |
Plasmodium berghei | PBANKA_1209800 | proteasome subunit beta type-5, putative |
Plasmodium falciparum | PF3D7_1011400 | proteasome subunit beta type-5 |
Plasmodium knowlesi | PKNH_0811200 | proteasome subunit beta type-5, putative |
Plasmodium vivax | PVX_094790 | proteasome subunit beta type-5, putative |
Plasmodium yoelii | PY06767 | proteosome PSMB5/8 protein |
Saccharomyces cerevisiae | YPR103W | proteasome core particle subunit beta 5 |
Schistosoma japonicum | Sjp_0062270 | ko:K02737 20S proteasome subunit beta 5, putative |
Schistosoma mansoni | Smp_164840 | proteasome catalytic subunit 3 (T01 family) |
Schmidtea mediterranea | mk4.013971.00 | Proteasome subunit beta type-8 |
Schmidtea mediterranea | mk4.004146.01 | Proteasome subunit beta type-8 |
Trypanosoma brucei gambiense | Tbg972.10.7450 | proteasome beta 5 subunit, putative |
Trypanosoma brucei | Tb927.10.6080 | proteasome subunit beta type-5, putative |
Trypanosoma congolense | TcIL3000_10_5130 | proteasome subunit beta type-5, putative |
Trypanosoma cruzi | TcCLB.507639.40 | proteasome subunit beta type-5, putative |
Trypanosoma cruzi | TcCLB.503781.70 | proteasome subunit beta type-5, putative |
Toxoplasma gondii | TGME49_218920 | proteasome subunit beta type, putative |
Theileria parva | TP01_0874 | proteasome subunit beta type 5, putative |
Trichomonas vaginalis | TVAG_013010 | Family T1, proteasome beta subunit, threonine peptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.6080 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.6080 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.6080 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.6080 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_K05C4.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K05C4.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K05C4.1 | Caenorhabditis elegans | sterile | wormbase |
YPR103W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1209800 | Plasmodium berghei | Essential | plasmo |
TGME49_218920 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mus musculus | proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) | Compounds | References |
Saccharomyces cerevisiae | proteasome core particle subunit beta 5 | Compounds | References |
Homo sapiens | proteasome (prosome, macropain) subunit, beta type, 8 | Compounds | References |
Homo sapiens | proteasome (prosome, macropain) subunit, beta type, 5 | Compounds | References |