Detailed view for Rv1467c

Basic information

TDR Targets ID: 981091
Mycobacterium tuberculosis, Probable acyl-CoA dehydrogenase FadE15

Source Database / ID:  Tuberculist 

pI: 4.9016 | Length (AA): 609 | MW (Da): 65906 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 605 3owa (A) 14 562 21.00 0 1 1.09993 0.27
36 466 2jif (A) 59 432 26.00 0 1 0.920918 -0.2
131 455 4m9a (D) 96 371 35.00 0 0.72 0.670062 0.46
142 455 2ix5 (A) 151 416 28.00 0.0022 0.94 0.648999 0.31

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_136659)

Species Accession Gene Product
Leishmania braziliensis LbrM.28.2710   acyl-CoA dehydrogenase, putative
Leishmania donovani LdBPK_282700.1   acyl-CoA dehydrogenase, putative
Leishmania infantum LinJ.28.2700   acyl-CoA dehydrogenase, putative
Leishmania major LmjF.28.2510   acyl-CoA dehydrogenase, putative
Leishmania mexicana LmxM.28.2510   acyl-CoA dehydrogenase, putative
Mycobacterium leprae ML2563   PROBABLE ACYL-CoA DEHYDROGENASE FADE5
Mycobacterium tuberculosis Rv0244c   Probable acyl-CoA dehydrogenase FadE5
Mycobacterium tuberculosis Rv1467c   Probable acyl-CoA dehydrogenase FadE15
Mycobacterium ulcerans MUL_1869   acyl-CoA dehydrogenase FadE15
Mycobacterium ulcerans MUL_1168   acyl-CoA dehydrogenase FadE5
Trypanosoma brucei gambiense Tbg972.11.13240   acyl-CoA dehydrogenase, putative
Trypanosoma brucei Tb927.11.11780   acyl-CoA dehydrogenase, putative
Trypanosoma congolense TcIL3000.11.12440   acyl-CoA dehydrogenase, putative
Trypanosoma cruzi TcCLB.508827.40   acyl-CoA dehydrogenase, putative

Essentiality

Rv1467c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.3640 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.3640 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.3640 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.3640 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Rv1467c (Mycobacterium tuberculosis), Probable acyl-CoA dehydrogenase FadE15
Title for this comment
Comment