Detailed view for Rv3307

Basic information

TDR Targets ID: 981105
Mycobacterium tuberculosis, Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)

Source Database / ID:  Tuberculist 

pI: 5.7419 | Length (AA): 268 | MW (Da): 27539 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

Gene Ontology

Mouse over links to read term descriptions.
GO:0006139   nucleobase, nucleoside, nucleotide and nucleic acid metabolic process  
GO:0004731   purine-nucleoside phosphorylase activity  
GO:0003824   catalytic activity  
GO:0009116   nucleoside metabolic process  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 268 1g2o (A) 7 268 99.99 0 1 2.21031 -1.42

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128114)

Species Accession Gene Product
Brugia malayi Bm1_37405   purine nucleoside phosphorylase I, inosine and guanosine-specific family protein
Candida albicans CaO19.7949   similar to human purine nucleoside phosphorylase
Candida albicans CaO19.317   similar to human purine nucleoside phosphorylase
Caenorhabditis elegans CELE_K02D7.1   Protein K02D7.1
Drosophila melanogaster Dmel_CG16758   CG16758 gene product from transcript CG16758-RD
Escherichia coli b2407   purine nucleoside phosphorylase II
Echinococcus granulosus EgrG_000635300   purine nucleoside phosphorylase
Echinococcus granulosus EgrG_002001800   purine nucleoside phosphorylase
Echinococcus granulosus EgrG_000636000   purine nucleoside phosphorylase
Echinococcus granulosus EgrG_000635800   inosine guanosine and xanthosine phosphorylase
Echinococcus granulosus EgrG_002001900   purine nucleoside phosphorylase
Echinococcus granulosus EgrG_000635700   purine nucleoside phosphorylase
Echinococcus granulosus EgrG_000635200   purine nucleoside phosphorylase
Echinococcus granulosus EgrG_000635600   purine nucleoside phosphorylase
Echinococcus granulosus EgrG_000636100   purine nucleoside phosphorylase
Echinococcus multilocularis EmuJ_000636000   purine nucleoside phosphorylase
Echinococcus multilocularis EmuJ_001124500   purine nucleoside phosphorylase
Echinococcus multilocularis EmuJ_000635200   purine nucleoside phosphorylase
Echinococcus multilocularis EmuJ_000635600   purine nucleoside phosphorylase
Echinococcus multilocularis EmuJ_000635800   purine nucleoside phosphorylase
Echinococcus multilocularis EmuJ_000635900   purine nucleoside phosphorylase
Echinococcus multilocularis EmuJ_000635300   purine nucleoside phosphorylase
Echinococcus multilocularis EmuJ_000635700   purine nucleoside phosphorylase
Giardia lamblia GL50803_91348   Purine nucleoside phosphorylase lateral transfer candidate
Homo sapiens 4860   purine nucleoside phosphorylase
Loa Loa (eye worm) LOAG_03590   hypothetical protein
Mycobacterium leprae ML0707c   Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP)
Mus musculus ENSMUSG00000021871   purine-nucleoside phosphorylase
Mus musculus ENSMUSG00000068417   purine-nucleoside phosphorylase 2
Mycobacterium tuberculosis Rv3307   Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)
Mycobacterium ulcerans MUL_2673   purine nucleoside phosphorylase
Onchocerca volvulus OVOC4424   Purine nucleoside phosphorylase homolog
Saccharomyces cerevisiae YLR209C   purine-nucleoside phosphorylase
Schistosoma japonicum Sjp_0088970   ko:K03783 purine-nucleoside phosphorylase, putative
Schistosoma japonicum Sjp_0106480   Purine nucleoside phosphorylase, putative
Schistosoma mansoni Smp_179110   purine nucleoside phosphorylase
Schistosoma mansoni Smp_090520   purine nucleoside phosphorylase
Schmidtea mediterranea mk4.002392.01   Purine nucleoside phosphorylase
Trichomonas vaginalis TVAG_222920   purine nucleoside phosphorylase I, putative

Essentiality

Rv3307 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b2407 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

Compound Source Reference
References
References
References

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Purine-nucleoside phosphorylase Compounds References
Homo sapiens purine nucleoside phosphorylase Compounds References
Bos taurus Purine nucleoside phosphorylase Compounds References
Mus musculus purine-nucleoside phosphorylase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0123 0.5205 1
0.2656 1 1
0.0416 0.7793 1
0.064 1 1
0.0186 0.7117 0.5
0.0722 1 1
0.1951 0.7903 1
0.1151 1 0.5
0.0281 0.7158 0.5
0.1951 0.7903 1
0.168372 1 1
0.0494 0.4117 1
0.0933 1 1
0.4918 1 1
0.2339 0.549 0.6676
0.0946 1 0.5
0.0258 0.5283 1
0.2995 1 1
0.0308 0.772 1
0.0418 0.6097 1
0.1198 1 0.5
0.0186 0.7117 0.5
0.0293 1 1
0.0645 0.4651 0.4628
0.0259 0.2584 1
0.3941 1 0.5
0.0428 0.4336 1
0.031 0.7661 1
0.0787 1 0.5
0.018 0.3289 0
0.2339 0.549 0.6676
0.053 0.6598 1
0.3972 1 0.5
0.1796 0.5589 1
0.0154 1 1
0.0294 1 0.5
0.0154 0.3007 0.9483
0.194 1 1
0.0408 0.7775 1
0.0136513 1 1
0.3818 1 1
0.5696 1 1
0.0154 1 0.5
0.0392 0.2764 1
0.052797 0.411619 0.413076
0.3675 1 1
0.1965 1 1
0.1397 1 1
0.0154 0.4239 0.9344
0.1965 1 1
0.0273 0.7412 0.9815
0.0154 0.3007 0.9483
0.1434 0.2777 1
0.0416 0.7793 1
0.2883 1 1
0.0146 0.2971 0.9356
0.0125 0.657 1
0.5766 1 1
0.5018 1 1
0.0809 0.8245 1
0.0426 0.259 1
0.0143 0.312 0.5
0.0918 1 1
0.0532 1 1
0.0713 0.4594 0.4594
0.0268 0.3558 0.9151
0.0266 0.5283 1
0.0769 0.2766 1
0.013 0.3719 1
0.0362 0.2972 1
0.0154 1 1
0.1169 1 1
0.0769 0.2766 1
0.0154 1 0.5
0.2339 0.549 0.6676
0.0369 1 1
0.0422 1 1
0.08 0.8877 1
0.4869 1 1
0.2725 1 1
0.0168 1 1
0.0645 0.4651 0.4628
0.08 0.8877 1
0.0443 0.4043 0.4339
0.1409 0.4127 1
0.52 0.4637 1
0.1953 1 0.5
0.0407 1 1
0.0239 0.3381 0.4708
0.1429 0.2596 1
0.0308 1 0.5
0.181 1 0.5
0.0273 1 1
0.1404 1 1
0.1179 1 0.5
0.0539 1 1
0.0529 0.6968 1
0.2359 0.9379 1
0.0138 0.295 0.9356
0.0369 1 1
0.0522 1 1
0.5798 1 1
0.1796 0.5589 1
0.0375 0.2655 0.1617
0.2045 0.381 1
0.0168 1 1
0.0834 1 1
0.0676 0.264 0.2822
0.0453 0.5401 1
0.1326 1 1
0.0154 1 1
0.0434 0.5552 1
0.0301 0.4084 1
0.0247 0.5283 1
0.1397 1 1
0.0548 0.8177 1
0.0144 0.3434 1
0.0494 0.4117 1
0.0186 0.7117 0.5
0.0929 1 0.5
0.0154 0.2788 1
0.0392 0.2764 1
0.0554 1 1
0.0645 1 1
0.0378 0.9688 1
0.0744 1 1
0.0308 0.711 1
0.0925 1 1
0.1106 1 1
0.0154 1 0.5
0.0529 0.6968 1
0.2877 1 1
0.2993 1 0.5
0.0154 0.6004 0.8871
0.1436 1 1
0.4918 1 1
0.5567 0.5065 1
0.0294 1 1
0.0123 0.6699 1
0.0918 1 1
0.2202 0.4063 0.4062
0.0931 1 1
0.0429 0.3912 0.933
0.0416 1 1
0.0186 0.7117 0.5
0.0535 0.9927 1
0.1716 0.3602 1
0.2877 1 1
0.1796 0.5589 1
0.0239 0.3381 0.4708
0.0308 1 0.5
0.0655 0.3674 1
0.0154 0.3046 0.2804
0.0154 0.5551 0.5249
0.5089 1 1
0.0283 0.4848 1
0.237 0.6486 0.6976
0.492 1 1
0.0546 1 0.5
0.078 1 1
0.5089 1 1
0.0287 0.3444 1
0.1453 0.2694 1
0.4004 1 1
0.0217 0.7498 1
0.0283 0.4848 1
0.237 0.6486 0.6976
0.2339 0.549 0.6676
0.1951 0.7903 1
0.0799 1 1
0.2883 1 1
0.4924 1 1
0.0378 0.2639 0.5786
0.3794 1 1
0.0527 0.7731 1
0.0531 0.3231 1
0.0256 0.291 1
0.0631 1 0.5
0.0124 0.2943 1
0.3236 1 0.5
0.0289 1 1
0.0918 1 1
0.08 0.8877 1
0.0308 0.5182 0.5
0.2656 1 1
0.1313 1 1
0.0154 0.5637 0.5249
0.5921 1 1
0.0392 0.2764 1
0.0574 0.6775 1
0.4985 1 0.5
0.0523 1 1
0.0531 1 1
0.053 1 1
0.0814 0.6863 1
0.0273 0.7412 0.9815
0.0146 0.2974 0.9356
0.0398 0.3217 1
0.0407 1 1
0.0461 0.468 1
0.0412 1 0.5
0.0769 0.2766 1
0.0968 0.5524 0.5
0.0392 0.2764 1
0.0339 0.2724 1
0.0261 0.5283 1
0.182 1 0.5
0.0143 0.312 0.5
0.0186 0.7117 0.5
0.197 1 0.5
0.1283 0.983 1
0.0586 1 1
0.1452 0.9247 1
0.2045 1 0.5
0.031 0.7661 1
0.0168 1 1
0.0947 1 1
0.0394 1 1
0.223 1 1
0.52 0.4637 1
0.0138 0.4175 1
0.0429 0.3912 0.933
0.0396 0.7942 1
0.0797 1 1
0.0273 1 1
0.0154 0.8857 1
0.0917 1 1
0.0256 0.291 1
0.0153 0.4406 1
0.0126733 0.43502 1
0.0154 0.3002 0.4018
0.0154 1 1
0.0759 1 0.5
0.0918 1 1
0.0411 1 1
0.1796 0.5589 1
0.039 0.4136 1
0.0333 1 0.5
0.0127 0.3659 0
0.0797 1 1
0.1951 0.7903 1
0.1796 0.5589 1
0.0650232 0.956155 1
0.0154 1 0.5
0.0281 0.7158 0.5
0.0154 1 0.5
0.0655 0.3674 1
0.0769 0.2766 1
0.0154 0.5205 1
0.1796 0.5589 1
0.0418 1 1
0.0404 0.4967 0.6418
0.0574 0.6775 1
0.0426 1 1
0.0888 0.4648 0.8301
0.1169 1 1
0.2656 1 1
0.2339 0.5494 0.6666
0.1151 1 0.5
0.1796 0.5589 1
0.0186 0.7141 1
0.0528 1 1
0.0154 1 1
0.1285 1 1
0.0814 0.6863 1
0.0186 0.7117 0.5
0.52 0.4637 1
0.0154 0.3781 1
0.1658 1 1
0.1607 1 1
0.3301 1 0.5
0.1066 1 1
0.0154 1 0.5
0.0392 0.2764 1
0.0413 1 1
0.078 1 1
0.0154 1 1
0.0426 0.259 1
0.0154 1 1
0.0527 0.6604 1
0.0814 0.6863 1
0.1537 1 1
0.1434 0.2777 1
0.0124 0.2738 1
0.2339 0.549 0.6676
0.1665 0.3496 1
0.0386 0.5896 0.5885
0.1169 1 1
0.1085 1 1
0.0186 0.7117 0.5
0.1835 0.3742 1
0.3501 1 1
0.1951 0.7903 1
0.0681 1 0.5
0.0404 0.7231 1
0.0288 0.4066 1
0.9343 0.2625 0.6309
0.3861 1 1
0.0268 0.3558 0.9151
0.0154 1 0.5
0.1453 0.2694 1
0.0947 1 1
0.0308 0.3556 1
0.0292 1 0.5
0.1965 1 1
0.0154 0.3749 1
0.5095 1 1
0.0154 0.2703 0.5497
0.1367 1 0.5
0.0425 0.6212 1
0.0519 0.7015 1
0.0186 0.7117 0.5
0.0287 0.3444 1
0.2398 1 1
0.4417 1 1
0.0119675 1 1
0.223 1 1
0.0154 0.3781 1
0.0186 0.7117 0.5
0.0129 1 0.5
0.1951 0.7903 1
0.0503 0.3487 1
0.0251 0.6284 1
0.0274 0.3234 1
0.0391 0.6575 0.9654
0.1216 1 1
0.4726 1 1
0.067 0.2538 0.0628
0.0138 0.295 0.9356
0.2154 1 0.5
0.0186 0.7117 0.5
0.055 0.7807 1
0.0802 1 1
0.1892 0.3492 1
0.0443 0.4043 0.4339
0.1609 1 1
0.1835 0.3742 1
0.0308 1 1
0.4943 1 1
0.0944 1 1
0.0393 0.9489 0.9457
0.0782 1 1
0.0967 1 1
0.0586 1 1
0.0404 0.7231 1
0.173 1 1
0.1013 1 1
0.0143 0.312 0.5
0.0923 1 1
0.1796 0.5589 1
0.119 1 1
0.1434 0.2777 1
0.0545 1 1
0.0154 0.4152 1
0.0668 1 1
0.0154 0.6625 0.5
0.0217 0.7498 1
0.1308 1 1
0.0499 1 0.5
0.0556 1 0.5
0.0888 0.4648 0.8301
0.1066 1 1
0.2087 1 1
0.4966 1 1
0.0374 1 0.5
0.1531 1 1
0.028 0.384 1
0.0186 0.7117 0.5
0.1951 0.7903 1
0.1077 1 1
0.0814 0.6863 1
0.1103 1 1
0.2154 1 0.5
0.0545 1 1
0.0893 1 1
0.4985 1 0.5
0.0631 1 0.5
0.0531 1 1
0.1537 1 1
0.0401 0.7797 1
0.4417 1 1
0.0544 0.7711 1
0.0154 0.316 0.7006
0.0535 1 1
0.0154 1 0.5
0.1796 0.5589 1
0.064 1 1
0.0154 0.5757 1
0.0262 0.5276 1
0.1698 1 0.5
0.0258 0.8594 0.9223
0.0283 1 1
0.1003 1 1
0.029 0.4227 1
0.1467 0.9182 1
0.0123 0.289 1
0.1658 1 1
0.2527 1 1
0.5291 0.3693 1
0.0523 1 1
0.0282 0.3049 0
0.0788 1 1
0.0615 0.3669 1
0.0258 0.6463 1
0.1409 0.4127 1
0.7111 0.9308 1
0.1218 1 1
0.0186 0.7117 0.5
0.0217 0.7498 1
0.0376 0.3673 0.725
0.1951 0.7903 1
0.0119238 1 0.5
0.0154 1 1
0.0374 1 1
0.0154 0.2974 0.5
0.0537 1 0.5
0.0379 1 1
0.0186 0.7117 0.5
0.0154 1 0.5
0.0127 0.3089 0.5
0.0261 0.5284 1
0.0534 0.6334 1
0.5455 1 0.5
0.0266 0.5283 1
0.1216 1 1
0.0411 1 1
0.044 0.653 1
0.0544 0.7711 1
0.0263 0.5972 1
0.0397 0.2639 1
0.0787 1 0.5
0.0408 1 0.5
0.52 0.4637 1
0.0397 0.2639 1
0.0249 0.7744 1
0.1796 0.5589 1
0.0249 0.5284 1
0.0281 0.7158 0.5
0.1054 1 1
0.1542 1 0.5
0.0154 0.2703 0.5497
0.0154 0.5757 1
0.0461 0.2885 0.2705
0.0146 0.2971 0.9356
0.2527 1 1
0.0168 1 1
0.0402 1 1
0.1951 0.7903 1
0.0629 1 1
0.0661 1 0.5
0.0154 1 0.5
0.0571 1 1
0.0125 0.657 1
0.0408 1 0.5
0.0154 0.4152 1
0.0124 0.2738 1
0.223 1 1
0.1824 0.346 1
0.4918 1 1
0.0339 0.2724 1
0.0453 0.5401 1
0.4918 1 1
0.0154 0.5757 1
0.0124 0.3021 0.5
0.0123 0.4716 0.5
0.1283 0.983 1
0.2382 1 1
0.0424 0.6261 1
0.0154 1 1
0.0308 1 0.5
0.0426 1 1
0.093 1 1
0.0251 0.5284 1
0.1593 1 1
0.2166 1 0.5
0.0123 0.4716 0.5
0.5144 1 1
0.0274 0.3342 1
0.0154 0.2586 1
0.0801 1 1
0.0802 1 1
0.5567 0.5065 1
0.0154 0.625 1
0.0273 1 1
0.1593 1 1
0.0869 1 0.5
0.4681 1 1
0.5862 1 1
0.0376 0.3673 0.725
0.0154 1 1
0.5329 1 0.5
0.1796 0.5589 1
0.0584 1 0.5
0.0494 0.4117 1
0.0527 0.7731 1
0.0392 0.2764 1
0.1098 1 1
0.0308 0.3556 1
0.0308 0.3589 0.6135

Assayability

Assay information

  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis purine nucleoside phosphorylase by spectrophotometric analysis

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Rv3307 (Mycobacterium tuberculosis), Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)
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