Detailed view for Rv1997

Basic information

TDR Targets ID: 981122
Mycobacterium tuberculosis, Probable metal cation transporter P-type ATPase A CtpF
Source Database / ID:  Tuberculist 

pI: 5.3195 | Length (AA): 905 | MW (Da): 95015 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 10

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 902 3wgu (A) 28 1006 28.00 0.0026 1 1.13569 1.05
10 899 2o9j (A) 3 989 36.00 0 1 1.27183 0.37
533 695 3skx (A) 505 634 43.00 0 1 0.370811 0.77
634 686 4dw8 (A) 211 262 42.00 0.61 0.91 0.561264 -0.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126674)

Species Accession Gene Product
Arabidopsis thaliana AT1G07810   calcium-transporting ATPase 1
Arabidopsis thaliana AT4G00900   calcium-transporting ATPase 2
Arabidopsis thaliana AT1G10130   calcium-transporting ATPase 3, ER-type
Arabidopsis thaliana AT1G07670   calcium-transporting ATPase 4
Babesia bovis BBOV_II005700   calcium ATPase SERCA-like, putative
Brugia malayi Bm1_23960   Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type
Brugia malayi Bm1_12695   Probable calcium-transporting ATPase KIAA0703
Candida albicans CaO19.7089   Ca++-Pump, ATPase
Candida albicans CaO19_7089   hypothetical protein
Caenorhabditis elegans CELE_K11D9.2   Protein SCA-1, isoform B
Caenorhabditis elegans CELE_ZK256.1   Protein PMR-1, isoform B
Cryptosporidium hominis Chro.70464   calcium-transporting ATPase 1, endoplasmic reticulum-type (calcium pump)
Cryptosporidium parvum cgd7_4190   cation-transporting P-type ATpase with 11 or more transmembrane domains
Dictyostelium discoideum DDB_G0284605   P-type ATPase
Drosophila melanogaster Dmel_CG32451   Secretory Pathway Calcium atpase
Drosophila melanogaster Dmel_CG3725   Calcium ATPase at 60A
Echinococcus granulosus EgrG_000244800   sarco:endoplasmic reticulum calcium ATPase
Echinococcus granulosus EgrG_000584100   calcium transporting ATPase type 2C member
Echinococcus granulosus EgrG_001008200   calcium transporting atpase
Echinococcus multilocularis EmuJ_001008200   calcium transporting atpase
Echinococcus multilocularis EmuJ_000244800   sarco:endoplasmic reticulum calcium ATPase
Echinococcus multilocularis EmuJ_000584100   calcium transporting ATPase type 2C member
Homo sapiens ENSG00000174437   ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Homo sapiens ENSG00000064270   ATPase, Ca++ transporting, type 2C, member 2
Homo sapiens ENSG00000074370   ATPase, Ca++ transporting, ubiquitous
Homo sapiens ENSG00000017260   ATPase, Ca++ transporting, type 2C, member 1
Homo sapiens ENSG00000196296   ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
Leishmania braziliensis LbrM.04.0030   calcium-translocating P-type ATPase
Leishmania donovani LdBPK_040010.1   calcium-translocating P-type ATPase
Leishmania infantum LinJ.04.0010   calcium-translocating P-type ATPase
Leishmania major LmjF.04.0010   calcium-translocating P-type ATPase
Leishmania mexicana LmxM.04.0010   calcium-translocating P-type ATPase,organelle-type calcium ATPase
Loa Loa (eye worm) LOAG_11064   hypothetical protein
Loa Loa (eye worm) LOAG_05762   hypothetical protein
Loa Loa (eye worm) LOAG_09191   calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type
Mus musculus ENSMUSG00000030730   ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
Mus musculus ENSMUSG00000029467   ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Mus musculus ENSMUSG00000034112   ATPase, Ca++ transporting, type 2C, member 2
Mus musculus ENSMUSG00000032570   ATPase, Ca++-sequestering
Mus musculus ENSMUSG00000020788   ATPase, Ca++ transporting, ubiquitous
Mycobacterium tuberculosis Rv1997   Probable metal cation transporter P-type ATPase A CtpF
Mycobacterium ulcerans MUL_0612   metal cation-transporting p-type ATPase F, CtpF
Neospora caninum NCLIV_030940   hypothetical protein
Oryza sativa 4333998   Os03g0730800
Oryza sativa 4332447   Os03g0281600
Plasmodium berghei PBANKA_0610400   non-SERCA-type Ca2+ -transporting P-ATPase, putative
Plasmodium berghei PBANKA_0207000   calcium-transporting ATPase, putative
Plasmodium falciparum PF3D7_0106300   calcium-transporting ATPase
Plasmodium falciparum PF3D7_1211900   non-SERCA-type Ca2+ -transporting P-ATPase
Plasmodium knowlesi PKNH_1312000   non-SERCA-type Ca2+ -transporting P-ATPase, putative
Plasmodium knowlesi PKNH_0207200   calcium-transporting ATPase, putative
Plasmodium vivax PVX_084625   P-type ATPase4, putative
Plasmodium vivax PVX_081455   calcium-transporting ATPase, putative
Plasmodium yoelii PY03970   ATPase, P-type, HAD superfamily, subfamily IC, putative
Plasmodium yoelii PY05776   calcium-translocating P-type ATPase, SERCA-type
Saccharomyces cerevisiae YGL167C   Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1
Schistosoma japonicum Sjp_0317920   IPR001757,ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter;IPR006068,ATPase, P-type cation-transporter, C-terminal,domain-co
Schistosoma japonicum Sjp_0052530   ko:K01537 Ca2+-transporting ATPase [EC3.6.3.8], putative
Schistosoma japonicum Sjp_0082130   Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, putative
Schistosoma japonicum Sjp_0082140   Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type, putative
Schistosoma japonicum Sjp_0047360   Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type, putative
Schistosoma japonicum Sjp_0214870   ko:K01537 Ca2+-transporting ATPase [EC3.6.3.8], putative
Schistosoma mansoni Smp_126300   calcium-transporting atpase 2 (atpase 2)
Schistosoma mansoni Smp_136710.2   calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)
Schistosoma mansoni Smp_007260.1   ATPase
Schistosoma mansoni Smp_136710.1   calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)
Schistosoma mansoni Smp_007260.2   ATPase
Schmidtea mediterranea mk4.000281.11  
Schmidtea mediterranea mk4.011570.00  
Schmidtea mediterranea mk4.011570.01  
Schmidtea mediterranea mk4.002316.00   Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type
Schmidtea mediterranea mk4.002153.00   Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type
Schmidtea mediterranea mk4.002519.02  
Schmidtea mediterranea mk4.003296.00  
Schmidtea mediterranea mk4.002519.03   Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type
Schmidtea mediterranea mk4.000281.10   Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type
Schmidtea mediterranea mk4.002519.04   Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type
Trypanosoma brucei gambiense Tbg972.5.4780   calcium-translocating P-type ATPase,calcium pump, putative
Trypanosoma brucei Tb927.5.3400   calcium-translocating P-type ATPase
Trypanosoma congolense TcIL3000_5_3840   calcium-translocating P-type ATPase
Trypanosoma cruzi TcCLB.503563.10   calcium-translocating P-type ATPase, putative
Trypanosoma cruzi TcCLB.509777.70   Calcium ATPase SERCA-like
Toxoplasma gondii TGME49_230420   sarco/endoplasmic reticulum Ca2+-ATPase
Theileria parva TP02_0524   calcium-transporting ATPase, putative
Trichomonas vaginalis TVAG_243570   cation-transporting ATPase, putative
Trichomonas vaginalis TVAG_388330   cation-transporting ATPase, putative

Essentiality

Rv1997 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.3400 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.5.3400 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.5.3400 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.5.3400 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_K11D9.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_K11D9.2 Caenorhabditis elegans larval arrest wormbase
CELE_K11D9.2 Caenorhabditis elegans larval lethal wormbase
CELE_K11D9.2 Caenorhabditis elegans slow growth wormbase
CELE_K11D9.2 Caenorhabditis elegans sterile wormbase
PBANKA_0207000 Plasmodium berghei Essential plasmo
PBANKA_0610400 Plasmodium berghei Slow plasmo
TGME49_230420 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 Compounds References
Rattus norvegicus Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Compounds References
Oryctolagus cuniculus Sarcoplasmic/endoplasmic reticulum calcium ATP-ase Compounds References
Rattus norvegicus Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0104 0.3386 1
0.0104 0.3386 1
0.0058 0.2938 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Rv1997 (Mycobacterium tuberculosis), Probable metal cation transporter P-type ATPase A CtpF
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