Detailed view for Rv2483c

Basic information

TDR Targets ID: 981244
Mycobacterium tuberculosis, Possible transmembrane phospholipid biosynthesis bifunctional enzyme PlsC: putative L-3-phosphoserine phosphatase (O-phosphoseri

Source Database / ID:  Tuberculist 

pI: 10.2506 | Length (AA): 580 | MW (Da): 61788 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 222 5is2 (A) 144 350 24.00 0 1 0.590159 0.38
24 187 4hh2 (A) 33 191 30.00 0.38 0.19 0.173959 1.97
36 250 3fvv (A) 3 221 24.00 0 1 0.69879 -0.35
39 242 1rku (A) 3 179 16.00 0 0.9 0.398824 0.34
290 494 5kym (A) 41 246 21.00 0 1 0.625548 -0.26
301 491 5kym (A) 52 242 26.00 0 1 0.74071 -0.96
469 558 3tul (D) 98 224 28.00 0.18 0.1 0.224572 0.26
505 580 4ke2 (A) 112 187 28.00 0.6 0.12 0.504434 -0.86
505 552 4x8w (H) 1 307 40.00 0.092 0.15 0.348159 1.45

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126904)

Species Accession Gene Product
Arabidopsis thaliana AT4G30580   1-acyl-sn-glycerol-3-phosphate acyltransferase 1
Babesia bovis BBOV_II006950   acyltransferase family protein
Brugia malayi Bm1_13890   Acyltransferase family protein
Candida albicans CaO19.250   potential acyltransferase similar to S. cerevisiae SLC1 (YDL052C) 1-acylglycerol-3-phosphate O-acyltransferase involved in sphin
Candida albicans CaO19.7881   potential acyltransferase similar to S. cerevisiae SLC1 (YDL052C) 1-acylglycerol-3-phosphate O-acyltransferase involved in sphin
Caenorhabditis elegans CELE_F59F4.4   Protein ACL-1
Caenorhabditis elegans CELE_T06E8.1   Protein ACL-2, isoform B
Cryptosporidium hominis Chro.80165   hypothetical protein
Cryptosporidium parvum cgd8_1400   glycerol-3-phosphate acyltransferase family, possible plant origin, possible signal peptide plus 2 transmembrane domains
Chlamydia trachomatis CT_453   glycerol-3-phosphate acyltransferase
Dictyostelium discoideum DDB_G0291332   hypothetical protein
Drosophila melanogaster Dmel_CG3812   CG3812 gene product from transcript CG3812-RB
Escherichia coli b3018   1-acyl-sn-glycerol-3-phosphate acyltransferase
Echinococcus granulosus EgrG_000101200   Msx-like
Echinococcus granulosus EgrG_000234000   Phospholipid glycerol acyltransferase
Echinococcus granulosus EgrG_000234300   1 acyl sn glycerol 3 phosphate acyltransferase
Echinococcus granulosus EgrG_000233900   1 acyl sn glycerol 3 phosphate acyltransferase
Echinococcus multilocularis EmuJ_000234000   Phospholipid glycerol acyltransferase
Echinococcus multilocularis EmuJ_000234300   1 acyl sn glycerol 3 phosphate acyltransferase
Echinococcus multilocularis EmuJ_000233900   1 acyl sn glycerol 3 phosphate acyltransferase
Echinococcus multilocularis EmuJ_000101200   homeobox
Homo sapiens ENSG00000204310   1-acylglycerol-3-phosphate O-acyltransferase 1
Homo sapiens ENSG00000169692   1-acylglycerol-3-phosphate O-acyltransferase 2
Leishmania braziliensis LbrM.32.2150   1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative
Leishmania donovani LdBPK_322070.1   1-acyl-sn-glycerol-3-phosphateacyltransferase-l ik eprotein, putative
Leishmania infantum LinJ.32.2070   1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative
Leishmania major LmjF.32.1960   1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative
Leishmania mexicana LmxM.31.1960   1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative
Loa Loa (eye worm) LOAG_14124   hypothetical protein
Loa Loa (eye worm) LOAG_08437   acyltransferase
Loa Loa (eye worm) LOAG_04757   hypothetical protein
Loa Loa (eye worm) LOAG_14472   hypothetical protein
Mycobacterium leprae ML1245   POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERI
Mus musculus ENSMUSG00000034254   1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
Mus musculus ENSMUSG00000026922   1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
Mycobacterium tuberculosis Rv2182c   1-acylglycerol-3-phosphate O-acyltransferase
Mycobacterium tuberculosis Rv2483c   Possible transmembrane phospholipid biosynthesis bifunctional enzyme PlsC: putative L-3-phosphoserine phosphatase (O-phosphoseri
Mycobacterium ulcerans MUL_3764   bifunctional transmembrane phospholipid biosynthesis enzyme PlsC
Mycobacterium ulcerans MUL_3537   1-acylglycerol-3-phosphate O-acyltransferase
Neospora caninum NCLIV_017010   Lysophosphatidic acid acyltransferase, related
Neospora caninum NCLIV_006550   hypothetical protein
Oryza sativa 4349006   Os10g0497100
Oryza sativa 4337061   Os04g0625200
Plasmodium berghei PBANKA_1308200   1-acyl-sn-glycerol-3-phosphate acyltransferase, putative
Plasmodium falciparum PF3D7_1444300   1-acyl-sn-glycerol-3-phosphate acyltransferase, putative
Plasmodium knowlesi PKNH_1238000   1-acyl-sn-glycerol-3-phosphate acyltransferase, putative
Plasmodium vivax PVX_118280   1-acyl-sn-glycerol-3-phosphate acyltransferase, putative
Plasmodium yoelii PY01678   1-acyl-sn-glycerol-3-phosphate acyltransferase (ec 2.3.1.51) (1-agp acyltransferase) (1-agpat) (lysophosphatidic acid acyltransf
Saccharomyces cerevisiae YDL052C   1-acylglycerol-3-phosphate O-acyltransferase SLC1
Schistosoma japonicum Sjp_0214540   ko:K00655 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC2.3.1.51], putative
Schistosoma mansoni Smp_000075   transcription factor
Schistosoma mansoni Smp_000070   1-acyl-sn-glycerol-3-phosphate o-acyltransferase
Schmidtea mediterranea mk4.011494.00  
Schmidtea mediterranea mk4.011154.00   1-acyl-sn-glycerol-3-phosphate o-acyltransferase
Trypanosoma brucei gambiense Tbg972.11.17020   1-acyl-sn-glycerol-3-phosphate acyltransferase, putative
Trypanosoma brucei Tb927.11.15150   1-acyl-sn-glycerol-3-phosphate acyltransferase, putative
Trypanosoma congolense TcIL3000.11.15320   1-acyl-sn-glycerol-3-phosphate acyltransferase, putative
Trypanosoma cruzi TcCLB.509157.60   1-acyl-sn-glycerol-3-phosphate acyltransferase, putative
Toxoplasma gondii TGME49_297640   acyltransferase domain-containing protein
Toxoplasma gondii TGME49_240860   acyltransferase domain-containing protein
Treponema pallidum TP0361   lysophosphatidic acid acyltransferase
Theileria parva TP02_0668   hypothetical protein
Wolbachia endosymbiont of Brugia malayi Wbm0733   1-acyl-sn-glycerol-3-phosphate acyltransferase

Essentiality

Rv2483c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2216 Mycobacterium tuberculosis essential nmpdr
Tb11.01.6800 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.6800 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.6800 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.6800 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b3018 Escherichia coli essential goodall
TGME49_240860 Toxoplasma gondii Probably essential sidik
TGME49_297640 Toxoplasma gondii Probably essential sidik
TGME49_240860 Toxoplasma gondii Probably non-essential sidik
TGME49_297640 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0141 0.4741 0.8035
0.0287 0.892 0
0.0364 0.3272 0.5068
0.0189 0.2516 0.9534
0.0364 0.3272 0.5068
0.013 0.3645 0
0.0262 0.945 0.9338
0.0223 0.419 0
0.0265 0.9577 0.9572
0.0364 0.3272 0.5068
0.0029 0.3448 0.9319
0.0291148 0.501703 0.460693
0.0187 0.9562 0
0.0088 0.4124 0.8171
0.0181 0.913 0
0.0364 0.3272 0.5068
0.0291148 0.501703 0.460693
0.0101 0.9412 0
0.0364 0.3272 0.5068
0.007 0.5578 0
0.0165 0.949 0
0.0017 0.3151 0
0.0364 0.3272 0.5068
0.007 0.5578 0
0.0276 0.9372 0
0.025 0.9493 0.9488
0.0257 0.7704 0.6309
0.0141 0.4741 0.8035
0.0201 0.9578 0.9572
0.0283 0.8057 0
0.0162 0.9543 0
0.0073 0.3046 0.6568
0.0364 0.3272 0.5068
0.0225 0.3518 0.9545
0.0262 0.945 0.9338
0.0073 0.3046 0.6568
0.0364 0.3272 0.5068
0.0343 0.957 0.9566
0.0174 0.9568 0.9549
0.028 0.2806 0.837

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Rv2483c (Mycobacterium tuberculosis), Possible transmembrane phospholipid biosynthesis bifunctional enzyme PlsC: putative L-3-phosphoserine phosphatase (O-phosphoseri
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