Detailed view for Rv1992c

Basic information

TDR Targets ID: 981417
Mycobacterium tuberculosis, Probable metal cation transporter P-type ATPase G CtpG

Source Database / ID:  Tuberculist 

pI: 5.5558 | Length (AA): 771 | MW (Da): 79277 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 5

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 85 1yjr (A) 4 69 21.00 0.000012 0.62 0.4089 -0.88
23 84 2qif (A) 6 66 25.00 0.000019 0.9 0.456415 -0.74
25 85 2rop (A) 128 187 20.00 0.000012 0.25 0.253118 0.13
151 755 4bbj (A) 77 734 28.00 0.000000000013 1 0.985695 0.61
163 754 4umw (A) 132 730 33.00 0.0000000099 1 1.09183 0.58
209 682 5mrw (B) 39 548 33.00 0 1 0.747886 1.36
231 755 4bbj (A) 191 734 36.00 0 1 1.06103 0.29
256 365 2hc8 (A) 216 325 41.00 0 1 0.684372 -0.79
449 702 3skx (A) 376 633 41.00 0 1 0.848542 -0.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein


No expression data available for this gene


Ortholog group members (OG5_131206)

Species Accession Gene Product
Arabidopsis thaliana AT4G30120   putative inactive cadmium/zinc-transporting ATPase HMA3
Arabidopsis thaliana AT2G19110   putative cadmium/zinc-transporting ATPase HMA4
Arabidopsis thaliana AT4G37270   putative cadmium/zinc-transporting ATPase HMA1
Arabidopsis thaliana AT4G30110   cadmium/zinc-transporting ATPase HMA2
Chlamydia trachomatis CT_727   metal transport ATPase
Escherichia coli b3469   zinc, cobalt and lead efflux system
Mycobacterium tuberculosis Rv1992c   Probable metal cation transporter P-type ATPase G CtpG
Oryza sativa 4342783   Os07g0232900
Oryza sativa 4341902   Os06g0690700
Oryza sativa 9267380   Os06g0700650
Schmidtea mediterranea mk4.035851.00  


Rv1992c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b3469 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site,, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model


Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv1992c (Mycobacterium tuberculosis), Probable metal cation transporter P-type ATPase G CtpG
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