Detailed view for Rv2776c

Basic information

TDR Targets ID: 981619
Mycobacterium tuberculosis, Probable oxidoreductase
Source Database / ID:  Tuberculist 

pI: 6.7376 | Length (AA): 309 | MW (Da): 33485 | Paralog Number: 10

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00111  
PF00175  
PF00970  

Gene Ontology

Mouse over links to read term descriptions.
GO:0051536   iron-sulfur cluster binding  
GO:0016491   oxidoreductase activity  
GO:0009055   electron carrier activity  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 308 2pia (A) 8 320 32.00 0 1 1.41265 -0.36
229 309 4zho (A) 4 90 22.00 0 1 0.522236 -0.64
261 298 4zhp (A) 38 80 45.00 0.16 0.93 0.406177 1.09

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132455)

Species Accession Gene Product
Escherichia coli b1803   putative YeaWX dioxygenase beta subunit, reductase component
Mycobacterium leprae ML2088c   putative cytochrome p450
Mycobacterium tuberculosis Rv3121   Probable cytochrome P450 141 Cyp141
Mycobacterium tuberculosis Rv3545c   Probable cytochrome P450 125 Cyp125
Mycobacterium tuberculosis Rv2776c   Probable oxidoreductase
Mycobacterium tuberculosis Rv0766c   Probable cytochrome P450 123 Cyp123
Mycobacterium tuberculosis Rv0778   Possible cytochrome P450 126 Cyp126
Mycobacterium tuberculosis Rv2266   Probable cytochrome P450 124 Cyp124
Mycobacterium tuberculosis Rv2268c   Probable cytochrome P450 128 Cyp128
Mycobacterium tuberculosis Rv1256c   Probable cytochrome P450 130 Cyp130
Mycobacterium tuberculosis Rv3518c   Probable cytochrome P450 monooxygenase 142 Cyp142
Mycobacterium tuberculosis Rv1785c   Probable cytochrome P450 143 Cyp143
Mycobacterium tuberculosis Rv1880c   Probable cytochrome P450 140 Cyp140
Mycobacterium ulcerans MUL_3872   cytochrome P450 187A5 Cyp187A5
Mycobacterium ulcerans MUL_1282   cytochrome P450 124A1, Cyp124A1
Mycobacterium ulcerans MUL_3106   cytochrome P450 143A3 Cyp143A3
Mycobacterium ulcerans MUL_0491   cytochrome P450 126A3 Cyp126A3
Mycobacterium ulcerans MUL_3863   cytochrome P450 108B4 Cyp108B4
Mycobacterium ulcerans MUL_0324   cytochrome P450 189A7 Cyp189A7
Mycobacterium ulcerans MUL_2159   oxidoreductase
Mycobacterium ulcerans MUL_0333   cytochrome P450 105Q4 Cyp105Q4
Mycobacterium ulcerans MUL_0475   cytochrome P450 123A3 Cyp123A3
Mycobacterium ulcerans MUL_4106   cytochrome P450 125A7 Cyp125A7
Mycobacterium ulcerans MUL_4077   cytochrome P450 142A3 Cyp142A3
Mycobacterium ulcerans MUL_3091   cytochrome P450 143A4 Cyp143A4
Mycobacterium ulcerans MUL_1049   cytochrome P450 191A3 Cyp191A3
Mycobacterium ulcerans MUL_0317   cytochrome P450 188A3 Cyp188A3
Mycobacterium ulcerans MUL_2979   cytochrome P450 140A5 Cyp140A5
Mycobacterium ulcerans MUL_3860   cytochrome P450 187A4 Cyp187A4
Mycobacterium ulcerans MUP053c   cytochrome p450 150 cyp150

Essentiality

Rv2776c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2301 Mycobacterium tuberculosis non-essential nmpdr
mtu2303 Mycobacterium tuberculosis essential nmpdr
mtu3579 Mycobacterium tuberculosis non-essential nmpdr
Mycobacterium tuberculosis non-essential nmpdr
b1803 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 Compounds References
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 Compounds References
Pseudomonas putida Cytochrome P450-cam Compounds References
Amycolatopsis orientalis Cytochrome P450 165B3 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0123 0.9319 0
0.0247 0.3384 0
0.0247 0.3384 0
0.0382 0.4906 0.935
0.0253 0.2855 0.9052
0.0247 0.3384 0
0.0267 0.3156 0.9026
0.0394 0.4585 0.9351
0.0238 0.9712 0

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Rv2776c (Mycobacterium tuberculosis), Probable oxidoreductase
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