Detailed view for OVOC170

Basic information

TDR Targets ID: 981988
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 9.067 | Length (AA): 411 | MW (Da): 47178 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03314  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_191926)

Species Accession Gene Product
Brugia malayi Bm1_00305   protein F46F5.4
Caenorhabditis elegans CELE_F25H2.7   Protein F25H2.7
Loa Loa (eye worm) LOAG_10353   hypothetical protein
Loa Loa (eye worm) LOAG_13829   hypothetical protein
Loa Loa (eye worm) LOAG_07922   hypothetical protein
Onchocerca volvulus OVOC11794  
Onchocerca volvulus OVOC11795  
Onchocerca volvulus OVOC170  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Somatostatin receptor 2 369 aa 24.1% 402 aa Compounds References
Rattus norvegicus Neuropeptide Y receptor type 1 382 aa 21.7% 378 aa Compounds References
Cavia porcellus Type-1 angiotensin II receptor 359 aa 20.6% 291 aa Compounds References
Rattus norvegicus Nociceptin receptor 367 aa 24.7% 352 aa Compounds References
Rattus norvegicus Somatostatin receptor 363 aa 25.1% 331 aa Compounds References
Sus scrofa Type-1 angiotensin II receptor 359 aa 20.2% 321 aa Compounds References
Cavia porcellus Nociceptin receptor 370 aa 23.7% 338 aa Compounds References
Rattus norvegicus Kappa opioid receptor 380 aa 20.8% 313 aa Compounds References
Danio rerio Mu opioid receptor-like OR2 384 aa 22.5% 315 aa Compounds References
Rattus norvegicus Somatostatin receptor 5 363 aa 25.1% 331 aa Compounds References
Rattus norvegicus Galanin receptor 2 372 aa 21.2% 306 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC170 (Onchocerca volvulus),
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