Detailed view for OVOC10762

Basic information

TDR Targets ID: 982862
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 7.6253 | Length (AA): 551 | MW (Da): 64587 | Paralog Number: 8169

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Populus kitakamiensis Trans-cinnamate 4-monooxygenase 505 aa 23.7% 528 aa Compounds References
Rattus norvegicus Thromboxane-A synthase 533 aa 21.7% 507 aa Compounds References
Rattus norvegicus Cytochrome P450 2C23 494 aa 31.9% 527 aa Compounds References
Rattus norvegicus Cytochrome P450 3A1 504 aa 23.3% 477 aa Compounds References
Rattus norvegicus Cytochrome P450 1A2 513 aa 26.3% 533 aa Compounds References
Canis familiaris Cytochrome P450 2B11 494 aa 33.7% 499 aa Compounds References
Rattus norvegicus Cytochrome P450 2D3 500 aa 31.8% 513 aa Compounds References
Rattus norvegicus Cytochrome P450 1A1 524 aa 25.3% 494 aa Compounds References
Oryctolagus cuniculus Cytochrome P450 2B4 491 aa 32.4% 491 aa Compounds References
Macaca fascicularis Steroid 17-alpha-hydroxylase/17,20 lyase 508 aa 24.0% 487 aa Compounds References
Rattus norvegicus Cytochrome P450 2A2 492 aa 30.8% 491 aa Compounds References
Rattus norvegicus Cytochrome P450 24A1 514 aa 20.2% 494 aa Compounds References
Rattus norvegicus Cytochrome P450 2E1 493 aa 28.7% 502 aa Compounds References
Rattus norvegicus Cytochrome P450 2D18 500 aa 31.9% 521 aa Compounds References
Helianthus tuberosus Trans-cinnamate 4-monooxygenase 505 aa 23.2% 512 aa Compounds References
Rattus norvegicus Cytochrome P450 2D2 500 aa 31.3% 469 aa Compounds References
Thlaspi arvense Cytochrome P450 71B1 496 aa 23.3% 503 aa Compounds References
Rattus norvegicus Cytochrome P450 2B1 491 aa 33.1% 474 aa Compounds References
Rattus norvegicus Cytochrome P450 2D1 504 aa 30.6% 509 aa Compounds References
Rattus norvegicus Cytochrome P450 17A1 507 aa 24.1% 453 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC10762 (Onchocerca volvulus),
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