Detailed view for OVOC5379

Basic information

TDR Targets ID: 983083
Onchocerca volvulus,

Source Database / ID:  Wormbase Parasite  

pI: 9.2112 | Length (AA): 379 | MW (Da): 42756 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

Gene Ontology

Mouse over links to read term descriptions.
GO:0005576   extracellular region  
GO:0005184   neuropeptide hormone activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
33 97 5b5i (A) 1 63 30.00 0 0.99 1.1371 -1.04
37 93 1j0t (A) 5 60 25.00 0 0.89 0.890329 -0.8

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_220485)

Species Accession Gene Product
Caenorhabditis elegans CELE_ZC168.2   Protein ZC168.2
Loa Loa (eye worm) LOAG_06623   hypothetical protein
Onchocerca volvulus OVOC5379  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Canis lupus familiaris Bradykinin B1 receptor 350 aa 22.7% 304 aa Compounds References
Oryctolagus cuniculus Growth hormone secretagogue receptor type 1 366 aa 23.8% 320 aa Compounds References
Rattus norvegicus Type-1B angiotensin II receptor 359 aa 18.8% 309 aa Compounds References
Rattus norvegicus Melatonin receptor 1B 364 aa 22.7% 295 aa Compounds References
Ovis aries Ghrelin receptor 366 aa 23.4% 299 aa Compounds References
Rattus norvegicus Ghrelin receptor 364 aa 23.2% 319 aa Compounds References
Sus scrofa Type-1 angiotensin II receptor 359 aa 19.7% 320 aa Compounds References
Rattus norvegicus Galanin receptor 2 372 aa 22.8% 338 aa Compounds References
Bos taurus Angiotensin II type 1a (AT-1a) receptor 359 aa 20.5% 317 aa Compounds References
Rattus norvegicus Type-1A angiotensin II receptor 359 aa 19.2% 312 aa Compounds References
Cavia porcellus Type-1 angiotensin II receptor 359 aa 19.1% 320 aa Compounds References
Rattus norvegicus Angiotensin II receptor (AT-1) type-1 359 aa 18.8% 309 aa Compounds References
Rattus norvegicus Angiotensin II receptor 359 aa 19.2% 312 aa Compounds References

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC5379 (Onchocerca volvulus),
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