Detailed view for OVOC11567

Basic information

TDR Targets ID: 983086
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 8.0113 | Length (AA): 619 | MW (Da): 70469 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 12

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02630  
PF05793  

Gene Ontology

Mouse over links to read term descriptions.
GO:0003824   catalytic activity  
GO:0006367   transcription initiation from RNA polymerase II promoter  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
136 313 2b7j (B) 113 290 34.00 0.0000000015 1 0.792302 -1.47
138 299 2ggt (A) 136 297 51.00 0 1 0.988023 -2.09

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127363)

Species Accession Gene Product
Arabidopsis thaliana AT3G08950   copper chaperone SCO1-like protein HCC1
Babesia bovis BBOV_III004250   SCO1/SenC family protein
Brugia malayi Bm1_14745   transcription initiation factor IIF, alpha subunit, putative
Candida albicans CaO19.7325   inner mitochondrial membrane protein
Caenorhabditis elegans CELE_C01F1.2   Protein SCO-1
Dictyostelium discoideum DDB_G0281505   hypothetical protein
Drosophila melanogaster Dmel_CG8885   Synthesis of cytochrome c oxidase
Echinococcus granulosus EgrG_000228900   SCO cytochrome oxidase deficient protein 1
Echinococcus multilocularis EmuJ_000228900   SCO cytochrome oxidase deficient protein 1
Homo sapiens ENSG00000133028   SCO1 cytochrome c oxidase assembly protein
Homo sapiens ENSG00000130489   SCO2 cytochrome c oxidase assembly protein
Leishmania braziliensis LbrM.04.1140   cytochrome c oxidase assembly factor, putative
Leishmania braziliensis LbrM.26.1890   electon transport protein SCO1/SCO2, putative
Leishmania donovani LdBPK_041140.1   cytochrome c oxidase assembly factor, putative
Leishmania donovani LdBPK_261970.1   electon transport protein SCO1/SCO2, putative
Leishmania infantum LinJ.04.1140   cytochrome c oxidase assembly factor, putative
Leishmania infantum LinJ.26.1970   electon transport protein SCO1/SCO2, putative
Leishmania major LmjF.26.1970   electon transport protein SCO1/SCO2, putative
Leishmania major LmjF.04.1130   cytochrome c oxidase assembly factor, putative
Leishmania mexicana LmxM.04.1130   cytochrome c oxidase assembly factor, putative
Leishmania mexicana LmxM.26.1970   electon transport protein SCO1/SCO2, putative
Loa Loa (eye worm) LOAG_07303   hypothetical protein
Mus musculus ENSMUSG00000091780   SCO cytochrome oxidase deficient homolog 2 (yeast)
Mus musculus 52892   SCO cytochrome oxidase deficient homolog 1 (yeast)
Neospora caninum NCLIV_029640   SCO1/SenC domain-containing protein, putative
Oryza sativa 4328372   Os02g0159700
Onchocerca volvulus OVOC11567  
Plasmodium berghei PBANKA_1219400   protein SCO1, putative
Plasmodium falciparum PF3D7_0708900   protein SCO1, putative
Plasmodium knowlesi PKNH_0107500   protein SCO1, putative
Plasmodium vivax PVX_087975   cloroquine resistance associated protein Cg3, putative
Plasmodium yoelii PY05062   Plasmodium falciparum CG3
Saccharomyces cerevisiae YBR024W   Sco2p
Saccharomyces cerevisiae YBR037C   Sco1p
Schistosoma japonicum Sjp_0094450   ko:K07152 SCO1, LOC489505; SCO cytochrome oxidase deficient homolog 1 (yeast), putative
Schistosoma mansoni Smp_034700.1   sco1-related
Schistosoma mansoni Smp_034700.3   sco1-related
Schmidtea mediterranea mk4.000936.03   Protein SCO2 homolog, mitochondrial
Schmidtea mediterranea mk4.038135.00   Protein SCO2 homolog, mitochondrial
Schmidtea mediterranea mk4.000936.01   Protein SCO2 homolog, mitochondrial
Schmidtea mediterranea mk4.002155.03   Protein SCO2 homolog, mitochondrial
Trypanosoma brucei gambiense Tbg972.9.4780   cytochrome c oxidase assembly factor, putative
Trypanosoma brucei gambiense Tbg972.9.1050   electon transport protein SCO1/SCO2, putative
Trypanosoma brucei Tb927.9.8680   cytochrome c oxidase assembly factor, putative
Trypanosoma brucei Tb427tmp.160.1140   electon transport protein SCO1/SCO2, putative
Trypanosoma brucei Tb927.9.2450   electon transport protein SCO1/SCO2, putative
Trypanosoma congolense TcIL3000_9_650   electon transport protein SCO1/SCO2, putative
Trypanosoma cruzi TcCLB.508351.40   cytochrome c oxidase assembly factor, putative
Trypanosoma cruzi TcCLB.506649.50   cytochrome c oxidase assembly factor, putative
Trypanosoma cruzi TcCLB.509535.9   electon transport protein SCO1/SCO2, putative
Trypanosoma cruzi TcCLB.504423.20   electon transport protein SCO1/SCO2, putative
Toxoplasma gondii TGME49_257440   SCO1/SenC protein
Theileria parva TP02_0242   SCO1-like, putative
Wolbachia endosymbiont of Brugia malayi Wbm0544   hypothetical protein

Essentiality

OVOC11567 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.1140 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.1140 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb09.160.1140 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.1140 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb09.211.0510 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.211.0510 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.211.0510 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.211.0510 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C01F1.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_C01F1.2 Caenorhabditis elegans larval arrest wormbase
CELE_C01F1.2 Caenorhabditis elegans sterile wormbase
YBR024W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1219400 Plasmodium berghei Essential plasmo
TGME49_257440 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Transporter 617 aa 37.4% 586 aa Compounds References
Rattus norvegicus GABA transporter 614 aa 42.6% 566 aa Compounds References
Rattus norvegicus GABA transporter 1 599 aa 42.9% 557 aa Compounds References
Rattus norvegicus GABA transporter 2 602 aa 41.2% 592 aa Compounds References
Rattus norvegicus Norepinephrine transporter 597 aa 38.6% 554 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC11567 (Onchocerca volvulus),
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