Detailed view for OVOC1921

Basic information

TDR Targets ID: 983423
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 7.6542 | Length (AA): 1533 | MW (Da): 175532 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00082  

Gene Ontology

Mouse over links to read term descriptions.
GO:0004252   serine-type endopeptidase activity  
GO:0006508   proteolysis  

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
29 406 3whi (A) 8 365 22.00 0 1 0.592637 0
68 534 1r6v (A) 86 574 19.00 0 1 0.611176 0.54
68 369 1r6v (A) 86 412 30.00 0.000016 1 0.475323 0.62
126 406 1bh6 (A) 9 275 33.00 0 1 0.69696 -0.86
128 553 2id4 (A) 154 586 15.00 0 1 0.495467 0.31
128 157 5jxg (A) 132 161 43.00 0.49 0.4 0.385619 1.05
128 406 1to2 (E) 11 275 31.00 0 1 0.667925 -0.91

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129929)

Species Accession Gene Product
Arabidopsis thaliana AT5G19660   SITE-1 protease
Brugia malayi Bm1_08700   Membrane-bound transcription factor site-1 protease precursor
Candida albicans CaO19.7464   one of two in tandem duplication
Candida albicans CaO19.7463   second of two in tandem duplication
Dictyostelium discoideum DDB_G0282397   membrane-bound transcription factor peptidase, site 1
Drosophila melanogaster Dmel_CG7169   CG7169 gene product from transcript CG7169-RA
Echinococcus granulosus EgrG_001148400   membrane bound transcription factor site 1
Echinococcus multilocularis EmuJ_001148400   membrane bound transcription factor site 1
Homo sapiens ENSG00000140943   membrane-bound transcription factor peptidase, site 1
Loa Loa (eye worm) LOAG_07390   hypothetical protein
Mus musculus ENSMUSG00000031835   membrane-bound transcription factor peptidase, site 1
Oryza sativa 4340224   Os06g0163500
Onchocerca volvulus OVOC1921  
Saccharomyces cerevisiae YCR045C   Rrt12p
Schistosoma japonicum Sjp_0047820   ko:K08653 membrane-bound transcription factor protease, site 1, putative
Schistosoma mansoni Smp_154140   site-1 peptidase (S08 family)
Schmidtea mediterranea mk4.001965.04   Membrane-bound transcription factor site-1 protease
Schmidtea mediterranea mk4.013513.00  
Schmidtea mediterranea mk4.001965.05   Membrane-bound transcription factor site-1 protease
Schmidtea mediterranea mk4.001965.06   Membrane-bound transcription factor site-1 protease
Schmidtea mediterranea mk4.001965.07   Membrane-bound transcription factor site-1 protease

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens membrane-bound transcription factor peptidase, site 1 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) DNA gyrase subunit B 648 aa 24.7% 669 aa Compounds References
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) DNA gyrase subunit B 675 aa 22.3% 622 aa Compounds References
Streptococcus pneumoniae ParE 638 aa 24.8% 585 aa Compounds References
Staphylococcus aureus DNA gyrase 644 aa 25.8% 624 aa Compounds References
Staphylococcus aureus Topoisomerase IV 663 aa 26.7% 614 aa Compounds References
Staphylococcus aureus DNA topoisomerase 4 subunit B 663 aa 26.7% 614 aa Compounds References
Staphylococcus aureus subsp. aureus Mu50 DNA gyrase 644 aa 25.8% 624 aa Compounds References
Mycobacterium smegmatis DNA gyrase subunit B 675 aa 22.3% 622 aa Compounds References
Staphylococcus aureus DNA gyrase subunit B 644 aa 25.8% 624 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.036 1 0.5
0.0102 1 0.5
0.0083 0.4881 0.4592
0.0801 1 0.5
0.0683 1 1
0.0683 1 1
0.0261 0.5416 1
0.0444 1 0.5
0.0437 1 1
0.0273 0.7727 1
0.0356 1 1
0.103964 0.833635 1
0.0683 1 1
0.0453 1 1
0.0345 1 1
0.0449 1 1
0.0167 1 0.5
0.0526 0.416 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC1921 (Onchocerca volvulus),
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