Detailed view for OVOC2045

Basic information

TDR Targets ID: 984478
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 8.7565 | Length (AA): 442 | MW (Da): 51205 | Paralog Number: 8169

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
29 208 5w0p (D) 129 337 29.00 0.39 0.2 0.694943 1.66

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Macaca fascicularis C-C chemokine receptor type 3 355 aa 22.0% 318 aa Compounds References
Macaca mulatta Mu-type opioid receptor 400 aa 24.2% 360 aa Compounds References
Xenopus laevis Melatonin receptor 1C 420 aa 22.8% 337 aa Compounds References
Cavia porcellus Serotonin 1d (5-HT1d) receptor 376 aa 21.7% 318 aa Compounds References
Cavia porcellus Beta-2 adrenergic receptor 418 aa 19.8% 348 aa Compounds References
Sus scrofa Ghrelin receptor 366 aa 22.7% 313 aa Compounds References
Sus scrofa Serotonin 4 (5-HT4) receptor 402 aa 23.4% 333 aa Compounds References
Rattus norvegicus Protein Gpr39 298 aa 20.5% 249 aa Compounds References
Rattus norvegicus Gastrin releasing peptide receptor 384 aa 22.0% 314 aa Compounds References
Cavia porcellus Kappa opioid receptor 380 aa 27.4% 310 aa Compounds References
Rattus norvegicus Serotonin 1f (5-HT1f) receptor 366 aa 20.8% 327 aa Compounds References
Rattus norvegicus Melanin-concentrating hormone receptor 1 360 aa 26.3% 323 aa Compounds References
Rattus norvegicus Thyrotropin-releasing hormone receptor 412 aa 21.3% 361 aa Compounds References
Rattus norvegicus Ghrelin receptor 364 aa 23.4% 308 aa Compounds References
Gallus gallus Melatonin receptor 346 aa 21.8% 330 aa Compounds References
Macaca mulatta Trace amine-associated receptor 1 338 aa 20.4% 339 aa Compounds References
Rattus norvegicus Bradykinin B2 receptor 396 aa 21.6% 329 aa Compounds References
Danio rerio Mu opioid receptor-like OR2 384 aa 25.4% 311 aa Compounds References
Rattus norvegicus C-C chemokine receptor type 2 373 aa 23.2% 354 aa Compounds References
Macaca mulatta Urotensin II receptor 389 aa 22.4% 361 aa Compounds References
Rattus norvegicus Neuropeptide FF receptor 2 417 aa 26.6% 354 aa Compounds References
Rattus norvegicus Galanin receptor 2 372 aa 23.5% 328 aa Compounds References
Rattus norvegicus C-X-C chemokine receptor type 4 349 aa 21.9% 334 aa Compounds References
Cavia porcellus Histamine H2 receptor 359 aa 24.3% 325 aa Compounds References
Rattus norvegicus Beta-2 adrenergic receptor 418 aa 19.9% 346 aa Compounds References
Rattus norvegicus Kappa opioid receptor 380 aa 26.8% 313 aa Compounds References
Rattus norvegicus Gonadotropin-releasing hormone receptor 327 aa 20.7% 271 aa Compounds References
Oryctolagus cuniculus Adenosine A3 receptor 319 aa 24.0% 262 aa Compounds References
Rattus norvegicus Neuropeptide Y receptor type 1 382 aa 23.1% 320 aa Compounds References
Bos taurus Angiotensin II type 1a (AT-1a) receptor 359 aa 25.5% 349 aa Compounds References
Sus scrofa Type-1 angiotensin II receptor 359 aa 24.4% 349 aa Compounds References
Rattus norvegicus Somatostatin receptor 1 391 aa 22.5% 320 aa Compounds References
Macaca mulatta C-X-C chemokine receptor type 4 352 aa 23.2% 358 aa Compounds References
Cavia porcellus mu/kappa opioid receptor 380 aa 27.4% 310 aa Compounds References
Rattus norvegicus Type-1B angiotensin II receptor 359 aa 23.9% 355 aa Compounds References
Macaca mulatta C-C chemokine receptor type 3 355 aa 21.2% 359 aa Compounds References
Rattus norvegicus Serotonin 4 (5-HT4) receptor 406 aa 24.1% 336 aa Compounds References
Macaca fascicularis Melanin-concentrating hormone receptor 1 249 aa 27.9% 262 aa Compounds References
Rattus norvegicus Vasopressin V1a receptor 424 aa 21.4% 378 aa Compounds References
Microtus ochrogaster Vasopressin V1a receptor 420 aa 19.5% 369 aa Compounds References
Rattus norvegicus Neurotensin receptor 2 416 aa 21.9% 361 aa Compounds References
Rattus norvegicus Nociceptin/mu opioid receptor 398 aa 23.9% 356 aa Compounds References
Mesocricetus auratus Beta-2 adrenergic receptor 418 aa 19.6% 341 aa Compounds References
Rattus norvegicus Nociceptin receptor 367 aa 25.4% 342 aa Compounds References
Rattus norvegicus Mu opioid receptor 398 aa 23.9% 356 aa Compounds References
Meleagris gallopavo P2Y purinoceptor 1 362 aa 24.7% 332 aa Compounds References
Rattus norvegicus Angiotensin II receptor (AT-1) type-1 359 aa 23.9% 355 aa Compounds References
Rattus norvegicus Opioid receptor 372 aa 22.1% 349 aa Compounds References
Cavia porcellus Nociceptin receptor 370 aa 25.7% 342 aa Compounds References
Bos taurus Mu opioid receptor 401 aa 24.6% 354 aa Compounds References
Cavia porcellus Mu opioid receptor 98 aa 32.9% 85 aa Compounds References
Canis lupus familiaris Beta-2 adrenergic receptor 415 aa 19.8% 353 aa Compounds References
Rattus norvegicus C5a anaphylatoxin chemotactic receptor 352 aa 21.9% 320 aa Compounds References
Cavia porcellus Serotonin 4 (5-HT4) receptor 388 aa 24.0% 321 aa Compounds References
Oryctolagus cuniculus Angiotensin II type 1a (AT-1a) receptor 359 aa 23.2% 341 aa Compounds References
Rattus norvegicus Somatostatin receptor 2 369 aa 23.8% 369 aa Compounds References
Rattus norvegicus Purinergic receptor P2Y1 373 aa 24.3% 338 aa Compounds References
Rattus norvegicus Thyrotropin-releasing hormone receptor 2 352 aa 21.0% 291 aa Compounds References
Rattus norvegicus Galanin receptor 1 346 aa 24.6% 309 aa Compounds References
Cavia porcellus Mu-opioid receptor 400 aa 25.1% 354 aa Compounds References
Rattus norvegicus Delta opioid receptor 372 aa 22.1% 349 aa Compounds References
Cavia porcellus Type-1 angiotensin II receptor 359 aa 23.2% 349 aa Compounds References
Rattus norvegicus Serotonin 1 (5-HT1) receptor 366 aa 20.8% 327 aa Compounds References
Rattus norvegicus Trace amine-associated receptor 1 332 aa 20.6% 344 aa Compounds References
Gallus gallus Melatonin receptor 1B 289 aa 18.5% 319 aa Compounds References
Rattus norvegicus Metastin receptor 396 aa 22.0% 327 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC2045 (Onchocerca volvulus),
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