pI: 8.857 |
Length (AA): 355 |
MW (Da): 40449 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 6
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 51 | 1lpv (A) | 4 | 52 | 35.00 | 0.000000013 | 0.5 | 0.599157 | 0.19 |
4 | 62 | 4yj0 (A) | 72 | 129 | 33.00 | 0.0000000012 | 0.46 | 0.68803 | -0.36 |
28 | 184 | 1xku (A) | 25 | 147 | 28.00 | 0.15 | 0.36 | 0.685506 | 1.14 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_218990)
Species | Accession | Gene Product |
---|---|---|
Caenorhabditis elegans | CELE_C32C4.5 | Protein MAB-23, isoform B |
Onchocerca volvulus | OVOC6127 |
|
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) | Human herpesvirus 5 chemokine receptor | 354 aa | 22.2% | 320 aa | Compounds | References |
Macaca fascicularis | C-C chemokine receptor type 5 | 352 aa | 21.2% | 335 aa | Compounds | References |
Rattus norvegicus | Trace amine-associated receptor 1 | 332 aa | 23.0% | 322 aa | Compounds | References |
Rattus norvegicus | Thyrotropin-releasing hormone receptor 2 | 352 aa | 23.6% | 343 aa | Compounds | References |
Rattus norvegicus | Bradykinin B1 receptor | 337 aa | 21.7% | 276 aa | Compounds | References |
Macaca mulatta | C-C chemokine receptor type 5 | 352 aa | 21.2% | 335 aa | Compounds | References |
Human cytomegalovirus | G protein-coupled receptor | 354 aa | 21.7% | 314 aa | Compounds | References |
Canis lupus familiaris | Bradykinin B1 receptor | 350 aa | 23.8% | 315 aa | Compounds | References |
Macaca mulatta | Trace amine-associated receptor 1 | 338 aa | 23.8% | 328 aa | Compounds | References |
Cavia porcellus | Platelet activating factor receptor | 342 aa | 21.0% | 300 aa | Compounds | References |
Rattus norvegicus | Platelet activating factor receptor | 341 aa | 21.3% | 319 aa | Compounds | References |
Cavia porcellus | Cysteinyl leukotriene receptor 1 | 340 aa | 19.9% | 317 aa | Compounds | References |
Macaca fascicularis | B1 bradykinin receptor | 352 aa | 25.2% | 318 aa | Compounds | References |
Macaca mulatta | B1 bradykinin receptor | 352 aa | 25.2% | 318 aa | Compounds | References |