Detailed view for OVOC6127

Basic information

TDR Targets ID: 984601
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 8.857 | Length (AA): 355 | MW (Da): 40449 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 6

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00751  

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005634   nucleus  
GO:0043565   sequence-specific DNA binding  
GO:0003700   transcription factor activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 51 1lpv (A) 4 52 35.00 0.000000013 0.5 0.599157 0.19
4 62 4yj0 (A) 72 129 33.00 0.0000000012 0.46 0.68803 -0.36
28 184 1xku (A) 25 147 28.00 0.15 0.36 0.685506 1.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_218990)

Species Accession Gene Product
Caenorhabditis elegans CELE_C32C4.5   Protein MAB-23, isoform B
Onchocerca volvulus OVOC6127  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) Human herpesvirus 5 chemokine receptor 354 aa 22.2% 320 aa Compounds References
Macaca fascicularis C-C chemokine receptor type 5 352 aa 21.2% 335 aa Compounds References
Rattus norvegicus Trace amine-associated receptor 1 332 aa 23.0% 322 aa Compounds References
Rattus norvegicus Thyrotropin-releasing hormone receptor 2 352 aa 23.6% 343 aa Compounds References
Rattus norvegicus Bradykinin B1 receptor 337 aa 21.7% 276 aa Compounds References
Macaca mulatta C-C chemokine receptor type 5 352 aa 21.2% 335 aa Compounds References
Human cytomegalovirus G protein-coupled receptor 354 aa 21.7% 314 aa Compounds References
Canis lupus familiaris Bradykinin B1 receptor 350 aa 23.8% 315 aa Compounds References
Macaca mulatta Trace amine-associated receptor 1 338 aa 23.8% 328 aa Compounds References
Cavia porcellus Platelet activating factor receptor 342 aa 21.0% 300 aa Compounds References
Rattus norvegicus Platelet activating factor receptor 341 aa 21.3% 319 aa Compounds References
Cavia porcellus Cysteinyl leukotriene receptor 1 340 aa 19.9% 317 aa Compounds References
Macaca fascicularis B1 bradykinin receptor 352 aa 25.2% 318 aa Compounds References
Macaca mulatta B1 bradykinin receptor 352 aa 25.2% 318 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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