Detailed view for OVOC12083

Basic information

TDR Targets ID: 985711
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 10.5626 | Length (AA): 59 | MW (Da): 6986 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00041  
PF00622  
PF00643  

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0008270   zinc ion binding  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 33 2ct2 (A) 12 46 48.00 0.27 0.82 0.255969 2.03
269 383 5iea (A) 97 221 21.00 0 0.92 0.461422 -0.74
477 570 2db8 (A) 9 102 52.00 0 1 0.708634 -0.08
481 568 2yuw (A) 11 103 33.00 0.88 0.81 0.351666 0.72
578 751 2fbe (B) 16 197 21.00 0 1 0.329776 -0.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130663)

Species Accession Gene Product
Brugia malayi Bm1_27175   B-box zinc finger family protein
Brugia malayi Bm1_22700   SPRY domain containing protein
Caenorhabditis elegans CELE_C39F7.2   Protein TRIM-9, isoform B
Drosophila melanogaster Dmel_CG31721   CG31721 gene product from transcript CG31721-RB
Echinococcus granulosus EgrG_000109600   E3 ubiquitin protein ligase TRIM9
Echinococcus granulosus EgrG_000109700   E3 ubiquitin protein ligase TRIM9
Echinococcus multilocularis EmuJ_000109700   E3 ubiquitin protein ligase TRIM9
Echinococcus multilocularis EmuJ_000109600   E3 ubiquitin protein ligase TRIM9
Homo sapiens ENSG00000100505   tripartite motif containing 9
Homo sapiens ENSG00000119283   tripartite motif containing 67
Loa Loa (eye worm) LOAG_11381   B-box zinc finger family protein
Loa Loa (eye worm) LOAG_12881   hypothetical protein
Loa Loa (eye worm) LOAG_11533   hypothetical protein
Mus musculus ENSMUSG00000036913   tripartite motif-containing 67
Mus musculus ENSMUSG00000021071   tripartite motif-containing 9
Onchocerca volvulus OVOC12083  
Schistosoma japonicum Sjp_0131660   Tripartite motif-containing protein 9, putative
Schistosoma japonicum Sjp_0131670   Tripartite motif-containing protein 67, putative
Schistosoma japonicum Sjp_0009500   Tripartite motif-containing protein 9, putative
Schistosoma japonicum Sjp_0130370   Tripartite motif-containing protein 9, putative
Schistosoma japonicum Sjp_0121500   IPR008957,Fibronectin, type III-like fold,domain-containing
Schistosoma mansoni Smp_113220   tripartite motif protein trim9
Schistosoma mansoni Smp_132840   tripartite motif protein trim9
Schmidtea mediterranea mk4.001865.00  
Schmidtea mediterranea mk4.008878.01  
Schmidtea mediterranea mk4.002065.05   Tripartite motif protein trim9, putative
Schmidtea mediterranea mk4.002619.00  
Schmidtea mediterranea mk4.006551.00   Tripartite motif protein trim9, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0223 0.4639 0
0.0083 1 0.5
0.0461 0.2819 0.999
0.0336 0.3462 1
0.0446 0.3014 0.4581
0.0313 0.5953 1
0.0156 0.6042 1
0.022 0.257 0.5704
0.0334 0.4633 0.6856
0.0446 0.3014 0.4581
0.0446 0.3014 0.4581
0.0216 0.706 1
0.0241 0.3619 0.7363
0.0111 0.334 0.299
0.0344 0.6972 0.984
0.0165 0.3513 0.7363
0.0048 0.4176 0.4167
0.0446 0.3014 0.4581
0.0016 1 0.5
0.0334 0.4633 0.6856
0.0129 0.3276 0.9467
0.0461 0.2819 0.999
0.0089 0.442 0.5
0.0374 0.7576 1
0.0116 0.6967 0.9164
0.0475 0.706 1
0.0251 0.7407 1
0.0338 0.7566 1
0.0403 0.706 1
0.0104 0.8804 1
0.0261 0.3873 0.7596
0.0089 0.442 0.5
0.0084 0.6788 0.5
0.0089 0.4623 1
0.0251 0.7407 1
0.0275 0.301 0.7543
0.0261 0.2557 0.639
0.0178 0.5983 0.5
0.0255 0.706 1
0.0156 0.6042 1
0.012 0.7362 0.9962
0.0048 0.432 0.432
0.0275 0.301 0.7543
0.0343 0.706 1
0.0216 0.3372 0.7239
0.0223 0.4639 0
0.0178 0.5983 0.5
0.0414 0.6115 0.5
0.0009 0.5 0.5
0.008 0.4641 0
0.0448 0.7636 1
0.0488 0.3798 1
0.0275 0.301 0.7543
0.0312 0.5397 1
0.0114 0.6153 1
0.02 0.7068 1
0.0075 0.4317 0.482
0.0351 0.6072 1
0.0275 0.301 0.7543
0.0034 0.2581 0
0.0132 0.2972 0.9819
0.0272 0.706 1
0.022 0.257 0.5704
0.0271 0.3613 1
0.0165 0.3513 0.7363
0.0153 0.3082 0.7487
0.0446 0.3014 0.4581
0.0255 0.706 1
0.0164 0.7647 0.7789
0.012 0.7362 0.9962
0.0115 0.2557 0.623
0.0084 0.6788 0.5
0.0461 0.2819 0.999
0.0446 0.3014 0.4581
0.0446 0.3014 0.4581
0.0461 0.2819 0.999
0.0266 0.2855 1
0.0471 0.341 1
0.037 0.706 1
0.0258 0.3891 0.7665
0.0142 0.2992 0.7505
0.0085 0.3268 0.6703
0.0378 0.586 0.5
0.0471 0.341 1
0.0167 0.3197 0.7196
0.0241 0.3986 0.7363
0.0414 0.6115 0.5
0.0343 0.706 1
0.0374 0.7576 1
0.043 0.5151 0.5
0.0167 0.3197 0.7196
0.017 0.2614 1
0.0184 0.706 1
0.0446 0.3014 0.4581
0.0255 0.2557 0.639
0.0378 0.586 0.5
0.0039 0.3299 0.3895
0.0275 0.301 0.7543
0.0155 0.3568 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier OVOC12083 (Onchocerca volvulus),
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