Detailed view for OVOC10460

Basic information

TDR Targets ID: 986133
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 7.5399 | Length (AA): 786 | MW (Da): 88469 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00498  

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 94 2jpe (A) 27 108 28.00 0.37 0.6 0.208385 0.93
8 126 5yyx (A) 25 136 28.00 0 0.82 0.195047 -0.18
21 109 6ccd (A) 20 99 26.00 0 0.95 0.228825 0.23
52 103 3po8 (A) 42 89 46.00 0.4 0.87 0.400618 0.54
584 663 4odp (A) 26 107 42.00 0.68 0.48 0.364959 0.07
750 958 5cwg (A) 3 196 20.00 0.53 0.24 0.269313 -0.2
1002 1058 5tbn (A) 0 52 20.00 0.029 0.26 0.249222 -0.51
1008 1054 2ma5 (A) 4 49 43.00 0.0091 0.97 0.407914 -0.18
1014 1054 2fui (A) 13 53 41.00 0.042 1 0.32427 0.53

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_160665)

Species Accession Gene Product
Brugia malayi Bm1_54880   hypothetical protein
Dictyostelium discoideum DDB_G0284587   hypothetical protein
Echinococcus granulosus EgrG_000516400   lysine specific demethylase 5B
Echinococcus granulosus EgrG_000516100   hypothetical protein
Echinococcus granulosus EgrG_000372600   Forkhead associated
Echinococcus multilocularis EmuJ_000372600   Forkhead associated
Echinococcus multilocularis EmuJ_000516400   lysine specific demethylase 5B
Echinococcus multilocularis EmuJ_000516100   Forkhead associated
Loa Loa (eye worm) LOAG_01926   hypothetical protein
Loa Loa (eye worm) LOAG_10734   hypothetical protein
Onchocerca volvulus OVOC10460  
Schistosoma japonicum Sjp_0302980   IPR011011,Zinc finger, FYVE/PHD-type;IPR000253,Forkhead-associated;IPR001965,Zinc finger, PHD-type;IPR008984,SMAD/FHA,domain-con
Schistosoma japonicum Sjp_0001470   expressed protein
Schistosoma mansoni Smp_096920   hypothetical protein
Schistosoma mansoni Smp_163540   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 24.7% 312 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 24.1% 303 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 25.0% 320 aa Compounds References
Sus scrofa Casein kinase I isoform alpha 125 aa 23.7% 131 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 26.6% 290 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 26.2% 290 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 23.6% 314 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 24.6% 325 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 24.0% 308 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 25.1% 291 aa Compounds References
Patiria pectinifera Cdc2 300 aa 24.5% 327 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC10460 (Onchocerca volvulus),
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