pI: 8.6387 |
Length (AA): 91 |
MW (Da): 10444 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
13 | 407 | 4czb (A) | 1 | 412 | 22.00 | 0 | 0.96 | 1.01042 | -0.09 |
17 | 409 | 4cz8 (A) | 4 | 421 | 26.00 | 0 | 0.96 | 1.01645 | -0.2 |
24 | 426 | 4czb (A) | 12 | 415 | 25.00 | 0 | 0.84 | 1.01128 | 0.44 |
132 | 184 | 2mdf (A) | 222 | 274 | 68.00 | 0 | 0.54 | 0.543917 | 2.83 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127664)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_40410 | sodium/hydrogen exchanger 3 family protein |
Caenorhabditis elegans | CELE_B0495.4 | Protein NHX-2 |
Caenorhabditis elegans | CELE_C54F6.13 | Protein NHX-3, isoform B |
Caenorhabditis elegans | CELE_ZK822.3 | Protein NHX-9, isoform C |
Caenorhabditis elegans | CELE_F58E1.6 | Protein NHX-6, isoform A |
Caenorhabditis elegans | CELE_B0395.1 | Protein NHX-1 |
Drosophila melanogaster | Dmel_CG9256 | Na[+]/H[+] hydrogen exchanger 2 |
Escherichia coli | b4065 | putative cation/proton antiporter |
Echinococcus granulosus | EgrG_001125700 | sodium:hydrogen exchanger |
Echinococcus granulosus | EgrG_001125600 | sodium:hydrogen exchanger 2 (nhe2) |
Echinococcus granulosus | EgrG_000188100 | sodium:hydrogen exchanger |
Echinococcus granulosus | EgrG_000062600 | sodium:hydrogen exchanger 2 nhe2 |
Echinococcus granulosus | EgrG_000062500 | sodium:hydrogen exchanger 2 nhe2 |
Echinococcus granulosus | EgrG_001138300 | sodium:hydrogen exchanger 2 nhe2 |
Echinococcus multilocularis | EmuJ_001125700 | sodium:hydrogen exchanger |
Echinococcus multilocularis | EmuJ_000062600 | sodium:hydrogen exchanger 2 (nhe2) |
Echinococcus multilocularis | EmuJ_001138300 | sodium:hydrogen exchanger 2 (nhe2) |
Echinococcus multilocularis | EmuJ_000188100 | sodium:hydrogen exchanger |
Echinococcus multilocularis | EmuJ_001125600 | sodium:hydrogen exchanger 2 (nhe2) |
Echinococcus multilocularis | EmuJ_000062500 | sodium:hydrogen exchanger 2 (nhe2) |
Giardia lamblia | GL50803_102647 | Sodium/hydrogen exchanger 3 |
Homo sapiens | ENSG00000180251 | solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 |
Homo sapiens | ENSG00000115616 | solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 |
Homo sapiens | ENSG00000066230 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 |
Homo sapiens | ENSG00000090020 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 |
Homo sapiens | ENSG00000135740 | solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 |
Loa Loa (eye worm) | LOAG_09955 | sodium/hydrogen exchanger 3 family protein |
Loa Loa (eye worm) | LOAG_10570 | sodium/hydrogen exchanger |
Loa Loa (eye worm) | LOAG_15711 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15340 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14194 | NHE-3 |
Loa Loa (eye worm) | LOAG_14248 | hypothetical protein |
Mus musculus | ENSMUSG00000014786 | solute carrier family 9 (sodium/hydrogen exchanger), member 5 |
Mus musculus | 226999 | solute carrier family 9 (sodium/hydrogen exchanger), member 2 |
Mus musculus | ENSMUSG00000036123 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 |
Mus musculus | ENSMUSG00000026065 | solute carrier family 9 (sodium/hydrogen exchanger), member 4 |
Mus musculus | ENSMUSG00000028854 | solute carrier family 9 (sodium/hydrogen exchanger), member 1 |
Onchocerca volvulus | OVOC1759 | Sodium\/hydrogen exchanger homolog |
Onchocerca volvulus | OVOC5204 | Sodium\/hydrogen exchanger homolog |
Onchocerca volvulus | OVOC2107 | Sodium\/hydrogen exchanger homolog |
Schistosoma japonicum | Sjp_0034380 | ko:K03316 monovalent cation:H+ antiporter, CPA1 family, putative |
Schistosoma japonicum | Sjp_0100370 | Sodium/hydrogen exchanger 2, putative |
Schistosoma japonicum | Sjp_0034390 | Sodium/hydrogen exchanger 2, putative |
Schistosoma mansoni | Smp_146750 | sodium/hydrogen exchanger |
Schistosoma mansoni | Smp_146740 | sodium/hydrogen exchanger 2 (nhe2) |
Schmidtea mediterranea | mk4.000325.01 | Na()/H() exchanger protein 7 |
Schmidtea mediterranea | mk4.000299.14 | |
Schmidtea mediterranea | mk4.004187.04 | Na()/H() exchanger protein 7 |
Schmidtea mediterranea | mk4.000010.11 | |
Schmidtea mediterranea | mk4.002853.00 | Na()/H() exchanger protein 7 |
Schmidtea mediterranea | mk4.009398.00 | Na()/H() exchanger protein 7 |
Schmidtea mediterranea | mk4.030465.00 | Na()/H() exchanger protein 7 |
Schmidtea mediterranea | mk4.000297.03 | Na()/H() exchanger protein 7 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b4065 | Escherichia coli | non-essential | goodall |
CELE_B0395.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_B0395.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_B0495.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_B0495.4 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F58E1.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 | Compounds | References |
Amphiuma tridactylum | Sodium/hydrogen exchanger | Compounds | References |
Oryctolagus cuniculus | Sodium/hydrogen exchanger | Compounds | References |
Homo sapiens | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | Compounds | References |
Rattus norvegicus | Sodium/hydrogen exchanger 1 | Compounds | References |
Homo sapiens | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 | Compounds | References |
Homo sapiens | solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 | Compounds | References |