Detailed view for OVOC4207

Basic information

TDR Targets ID: 986265
Onchocerca volvulus, Netrin receptor homolog

Source Database / ID:  Wormbase Parasite  

pI: 11.1595 | Length (AA): 63 | MW (Da): 7408 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0007165   signal transduction  

Metabolic Pathways

Structural information

Modbase 3D models:

There are 16 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
26 109 4v2b (A) 52 135 26.00 0.92 0.78 0.376721 -0.24
29 303 5ftt (A) 55 307 45.00 0 1 0.639174 0.82
45 205 2om5 (A) 29 179 29.00 0.074 1 0.276174 1.15
77 221 2a38 (A) 47 193 28.00 0.55 0.58 0.288332 0.74
83 240 3dmk (A) 541 704 33.00 0.000036 0.24 0.161016 1.41
132 225 2cqv (A) 9 99 27.00 0 0.86 0.413047 -0.59
137 223 2iep (A) 127 210 31.00 0.013 1 0.556279 -1.03
147 225 2yd6 (A) 142 221 42.00 0.005 0.83 0.460858 -0.13
224 352 1lsl (A) 417 527 36.00 0 1 0.219889 0.91
283 349 3vdj (A) 307 370 20.00 0 0.1 0.181626 -0.96
303 348 3ghm (A) 385 433 48.00 0.00012 0.95 0.632121 -0.87
545 847 4d8o (A) 966 1296 12.00 0 0.61 0.284047 1
553 943 3g5b (A) 549 941 28.00 0 1 0.667679 0.06
553 686 2kxr (A) 10 118 27.00 0 1 0.0571526 0.99
852 947 2dbf (A) 5 95 34.00 0.0039 1 0.551753 -1.29
855 947 1d2z (A) 35 123 20.00 0 0.94 0.295995 -0.89

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129284)

Species Accession Gene Product
Brugia malayi Bm1_31555   Immunoglobulin I-set domain containing protein
Caenorhabditis elegans CELE_B0273.4   Protein UNC-5, isoform A
Drosophila melanogaster Dmel_CG8166   CG8166 gene product from transcript CG8166-RB
Echinococcus granulosus EgrG_000069600   netrin receptor unc 5
Echinococcus multilocularis EmuJ_000069600   netrin receptor unc 5
Homo sapiens ENSG00000107731   unc-5 homolog B (C. elegans)
Homo sapiens ENSG00000182168   unc-5 homolog C (C. elegans)
Homo sapiens ENSG00000156687   unc-5 homolog D (C. elegans)
Homo sapiens ENSG00000113763   unc-5 homolog A (C. elegans)
Loa Loa (eye worm) LOAG_02525   immunoglobulin I-set domain-containing protein
Loa Loa (eye worm) LOAG_15378   hypothetical protein
Mus musculus ENSMUSG00000020099   unc-5 homolog B (C. elegans)
Mus musculus ENSMUSG00000063626   unc-5 homolog D (C. elegans)
Mus musculus ENSMUSG00000025876   unc-5 homolog A (C. elegans)
Mus musculus ENSMUSG00000059921   unc-5 homolog C (C. elegans)
Onchocerca volvulus OVOC4207   Netrin receptor homolog
Schistosoma japonicum Sjp_0080750   ko:K07521 netrin receptor unc-5, putative
Schistosoma japonicum Sjp_0098730   expressed protein
Schistosoma mansoni Smp_165440   netrin receptor unc5
Schmidtea mediterranea mk4.028347.00   Putative netrin receptor unc5
Schmidtea mediterranea mk4.019102.01   Putative netrin receptor unc5
Schmidtea mediterranea mk4.011227.02   Putative netrin receptor unc5
Schmidtea mediterranea mk4.028347.01  
Schmidtea mediterranea mk4.004578.00   Putative netrin receptor unc5
Schmidtea mediterranea mk4.011227.00  
Schmidtea mediterranea mk4.015711.00  
Schmidtea mediterranea mk4.024940.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0042 0.415 0
0.0421 0.5003 1
0.0273 0.6065 0.5
0.0026 0.5 0.5
0.004 0.2952 0.2941
0.0018 0.2769 0
0.0018 0.2769 0
0.0286 0.3229 1
0.0174 0.5698 1
0.0021 0.5 0.5
0.0258 0.2548 1
0.0018 0.2769 0
0.053 0.3214 0.5
0.0207 0.6335 1
0.0018 0.2769 0
0.0093 0.3031 0.5616
0.0241 0.2927 0
0.0126 0.5398 0.5
0.0231 0.3001 0.723
0.0666 0.6271 0.5
0.0062 0.2769 0
0.0052 0.5 0.5
0.0514 0.6489 1
0.0546 0.3645 1
0.0021 0.5 0.5
0.0018 0.2769 0
0.0026 1 0.5
0.0235 0.5904 1
0.0093 0.2758 1
0.0086 0.3911 1
0.0126 0.5398 0.5
0.0018 0.2769 0
0.0108 0.3495 0.3003
0.041 0.6463 1
0.0258 0.2548 1
0.0026 0.367 0.5
0.0246 0.2927 0
0.0056 0.6413 1
0.0186 0.648 1
0.0046 0.2932 0.6215
0.0258 0.2849 0
0.0052 0.5 0.5
0.0018 0.2769 0
0.0788 0.6409 1
0.0113 0.2769 0
0.0126 0.2782 0.5557
0.0844 0.359 1
0.0062 0.2769 0
0.0193 0.6562 1
0.0035 0.8097 1
0.0701 0.648 1
0.03 0.6494 1
0.0467 0.4298 1
0.0238 0.364 1
0.0066 0.5 0.5
0.0093 0.2758 1
0.0159 0.6257 0.5
0.0283 0.2568 0.9933
0.0114 0.2528 1
0.0233 0.3763 0.7115
0.0194 0.6318 1
0.0052 0.5 0.5
0.0191 0.6362 1
0.0074 0.2516 0.571
0.0044 0.3189 0.3869
0.0921 0.6522 1
0.0209 0.5748 0.5
0.0146 0.2897 0.7929
0.0052 0.5 0.5
0.0126 0.5117 1
0.0516 0.3551 1
0.0018 0.2769 0
0.0131 0.2567 0.6802
0.0018 0.2769 0
0.0018 0.2769 0
0.0671 0.6473 1
0.0097 0.4851 0.5
0.0086 0.3911 1
0.0892 0.6112 1
0.0248 0.5901 1
0.0263 0.3923 1
0.0421 0.5003 1
0.0052 0.5 0.5
0.02 0.4204 1
0.005 0.6137 0.5
0.0055 0.2635 0.2882
0.0215 0.3289 0.692
0.0301 0.3235 0.3235
0.0115 0.5076 1
0.0058 0.2789 0.2399
0.0015 0.2769 0
0.0119 0.5819 0.5
0.0177 0.3555 0.8588
0.0035 0.5756 0.5
0.0562 0.4719 1
0.0038 0.4237 0
0.0062 0.2769 0
0.0115 0.3847 0
0.004 0.3126 0.3126
0.0116 0.2785 0.6108
0.0788 0.6409 1
0.0177 0.3555 0.8588
0.0205 0.3124 0
0.041 0.6463 1
0.0528 0.6521 1
0.0432 0.4105 1
0.0204 0.4903 1
0.0085 0.4475 0.5
0.0528 0.6521 1
0.0018 0.2769 0
0.0259 0.2845 1
0.0236 0.2561 0.671
0.0576 0.6307 1
0.0127 0.6401 1
0.0281 0.6404 1
0.0482 0.5133 1
0.0064 0.2527 1
0.0215 0.3289 0.692
0.0844 0.359 1
0.0536 0.334 1
0.0248 0.6391 0.5
0.0109 0.4069 0.5702
0.0128 0.2957 0.6796
0.0177 0.3555 0.8588
0.0018 0.2769 0
0.0248 0.2975 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier OVOC4207 (Onchocerca volvulus), Netrin receptor homolog
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