Detailed view for OVOC1662

Basic information

TDR Targets ID: 986276
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 8.7834 | Length (AA): 530 | MW (Da): 61262 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00246  
PF01549  
PF02244  

Gene Ontology

Mouse over links to read term descriptions.
GO:0004180   carboxypeptidase activity  
GO:0008270   zinc ion binding  
GO:0004181   metallocarboxypeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
60 497 1jqg (A) 4 308 31.00 0 1 1.11694 -0.62
66 497 1pca (A) 10 308 36.00 0 1 1.21921 -0.85
177 496 5mrv (A) 25 327 36.00 0 1 1.07265 -1.22
178 495 2c1c (A) 8 306 32.00 0 1 1.01607 -1.19
395 436 4cu5 (A) 220 264 45.00 0.77 0.25 0.465534 0.06

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_155072)

Species Accession Gene Product
Caenorhabditis elegans CELE_T06A4.3   Protein T06A4.3, isoform B
Drosophila melanogaster Dmel_CG4408   CG4408 gene product from transcript CG4408-RA
Drosophila melanogaster Dmel_CG2915   CG2915 gene product from transcript CG2915-RA
Loa Loa (eye worm) LOAG_07890   zinc carboxypeptidase
Loa Loa (eye worm) LOAG_15723   hypothetical protein
Loa Loa (eye worm) LOAG_07433   hypothetical protein
Onchocerca volvulus OVOC1662  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Helicoverpa zea Carboxypeptidase B 429 aa 32.5% 431 aa Compounds References
Sus scrofa Carboxypeptidase B 416 aa 34.9% 421 aa Compounds References
Bos taurus Carboxypeptidase A1 419 aa 36.3% 422 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0733 0.2704 1
0.0781 1 0.5
0.0228 1 0.5
0.0373 0.5 0.5
0.0488 0.9045 0.9004
0.0173 0.5 0.5
0.1505 1 1
0.0136 0.5 0.5
0.0442 0.2652 1
0.0488 0.9045 0.9004
0.0698 0.5936 1
0.1371 0.7951 1
0.0473 1 1
0.0557 1 0.5
0.0068 0.5 0.5
0.0173 0.2723 1
0.0344 0.3226 1
0.0108 0.7425 1
0.0136 0.5 0.5
0.0488 0.9045 0.9004
0.0631 1 1
0.0396 0.5 0.5
0.0068 1 1
0.0247 0.2745 0.9687
0.0068 0.5 0.5
0.0741 1 0.5
0.0148 1 0.5
0.0148 1 0.5
0.0068 0.5 0.5
0.0136 0.7487 1
0.0136 0.5 0.5
0.0055 0.4963 1
0.0739 1 1
0.0741 1 0.5
0.0058 1 1
0.0488 1 1
0.0473 1 1
0.0283 1 1
0.0195 0.5 0.5
0.0121 0.2568 0.3576
0.1208 0.5 0.5
0.0378 0.7952 1
0.0205 0.5 0.5
0.0063 1 0.5
0.0068 1 1
0.1172 0.6697 0.6697
0.1324 1 1
0.0635 1 1
0.0488 0.9045 0.9004
0.0327 0.5167 1
0.0464 1 1
0.0665 1 1
0.0638 0.8036 1
0.0159 0.302 1
0.0136 0.5 0.5
0.07 1 1
0.0148 1 0.5
0.0074 1 0.5
0.0068 0.5 0.5
0.1371 0.7951 1
0.0068 0.5 0.5
0.0068 0.5 0.5
0.0726 0.5 0.5
0.1371 0.7951 1
0.1278 0.5 0.5
0.1426 1 1
0.0068 0.5 0.5
0.0068 0.5 0.5
0.1379 1 1
0.07142 1 1
0.0508 0.4382 1
0.0493 0.3178 1
0.1054 0.2931 0.2922
0.0638 0.8036 1
0.0607 0.3426 1
0.0055 1 0.5
0.0727 0.3598 1
0.1054 0.2931 0.2922
0.1054 0.2931 0.2922
0.0115 0.2988 1
0.0068 0.5 0.5
0.0476 0.5352 1
0.0068 0.5 0.5
0.0115 0.2988 1
0.0611 0.3443 1
0.0222 1 0.5
0.0374 0.6819 1
0.0068 0.5 0.5
0.0479 1 0.5
0.0771 1 1
0.0136 0.5 0.5
0.0637 0.3814 1
0.0068 0.5 0.5
0.0368 1 1
0.0136 0.5 0.5
0.0344 0.4343 1
0.0247 1 1
0.024 1 0.5
0.0068 1 0.5
0.0727 0.3598 1
0.0068 1 1
0.0136 0.5 0.5
0.079 0.5 0.5
0.1371 0.7951 1
0.038 0.6714 1
0.0148 1 0.5
0.0409 0.423 0.705
0.0068 0.5 0.5
0.0068 0.5 0.5
0.0136 0.5 0.5
0.0056 0.3639 1
0.024 0.9956 1
0.0068 0.2736 0.5
0.0729 0.5148 1
0.0488 0.9045 0.9004
0.067 1 1
0.0723 0.6232 1
0.0121 0.4521 1
0.1172 0.6696 0.6695
0.1167 0.5 0.5
0.0353 0.5699 0.9152
0.0136 1 1
0.0324 1 1
0.1426 1 1
0.0344 0.9339 0.5
0.064 0.3096 1
0.0574 1 0.5
0.0508 0.4382 1
0.1504 1 1
0.0148 1 1
0.0524 1 1
0.0126 1 1
0.0205 0.5 0.5
0.1054 0.2931 0.2922
0.0377 1 1
0.0136 0.5 0.5
0.0587 0.2599 1
0.0068 0.5 0.5
0.0068 0.5 0.5
0.0327 0.3204 1
0.0251 0.5 0.5
0.0114 0.5 0.5
0.0148 0.2938 0.5
0.0136 0.5 0.5
0.0068 0.5 0.5
0.0344 0.6106 1
0.0437 1 1
0.0233 0.7853 1
0.0148 1 0.5
0.0068 0.5 0.5
0.0068 0.5 0.5
0.0136 0.5 0.5
0.0414 1 0.5
0.011 1 1
0.0723 0.6232 1
0.0442 0.2652 1
0.1371 0.7951 1
0.0724 0.7342 1
0.0279 1 0.5
0.0068 0.5 0.5
0.008 1 1
0.0068 0.5 0.5
0.024 1 0.5
0.0416 1 1
0.0136 0.5 0.5
0.0136 0.5 0.5
0.0698 1 1
0.0136 0.5 0.5
0.0409 0.4788 1
0.0068 0.5 0.5
0.2256 0.7621 1
0.0426 0.5169 0.7211
0.0315 1 1
0.0259 1 1
0.0379 1 1
0.0136 0.5 0.5
0.0068 0.5 0.5
0.0446 1 1
0.0068 0.5 0.5
0.0445 0.7734 1
0.0148 1 0.5
0.024 0.8645 1
0.0426 0.5169 0.7211
0.0068 0.5 0.5
0.0332 1 1
0.0426 0.5169 0.7211
0.0068 0.7836 0.7723
0.0704 1 1
0.0068 0.5 0.5
0.0068 0.3501 0.5
0.1371 0.7951 1
0.0721 0.5 0.5
0.1329 1 1
0.0068 0.5 0.5
0.0222 1 0.5
0.1323 0.865 1
0.0587 0.2599 1
0.0409 1 1
0.0068 0.3555 0.3915
0.0508 0.4382 1
0.0052 0.2731 0.5
0.1371 0.7951 1
0.0366 1 1
0.0285 0.4744 1
0.0068 1 0.5
0.0235 0.3312 1
0.0136 0.5 0.5
0.1208 0.5 0.5
0.0428 1 1
0.0723 0.6232 1
0.0343 0.6191 1
0.0068 0.5 0.5
0.0066 0.5 0.5
0.011 1 0.5
0.0331 0.9651 1
0.0115 0.2988 1
0.0068 0.5 0.5
0.007 1 1
0.0343 0.2855 1
0.0709 1 1
0.0239 0.299 0.7587
0.1324 1 1
0.0205 0.5 0.5
0.0681 1 1
0.0148 0.4298 1
0.0682 0.5 0.5
0.0067 1 1
0.0233 0.7853 1
0.034 0.3795 1
0.0277 1 1
0.0068 0.5 0.5
0.00480833 1 0.5
0.0552 1 1
0.0136 0.5 0.5
0.0124 0.4662 1
0.0068 0.8051 0.7949
0.077 1 1
0.0723 0.6232 1
0.0698 0.5936 1
0.0386 0.4553 1
0.1148 1 1
0.0068 0.5 0.5
0.0374 0.6819 1
0.0136 0.5 0.5
0.0055 1 0.5
0.0136 0.5 0.5
0.0121 1 1
0.0136 0.5 0.5
0.103 1 0.5
0.0136 0.5 0.5
0.03 1 0.5
0.006 1 0.5
0.0068 1 0.5
0.0488 0.9045 0.9004
0.0701 0.8841 1
0.0146 0.2825 1
0.103 1 0.5
0.1242 0.5 0.5
0.00480833 1 0.5
0.0136 1 0.5
0.0068 0.5 0.5
0.0172 0.2562 0.5
0.0068 0.5 0.5
0.0136 1 0.5
0.0264 0.3274 0.6789
0.0068 0.5 0.5
0.0405 0.3397 1
0.0251 0.5 0.5
0.0136 1 0.5
0.0068 0.5 0.5
0.0446 1 1
0.0109 0.3599 0.4513
0.0107 0.3733 1
0.0136 1 0.5
0.0068 0.5 0.5
0.0068 0.5 0.5
0.1234 0.3488 1
0.0426 0.5169 0.7211
0.0189 1 1
0.0068 0.5 0.5
0.0112 0.5 0.5
0.0112 0.5 0.5
0.0358 1 1
0.0426 0.5169 0.7211
0.0067 1 1
0.0337 1 0.5
0.0068 0.5 0.5
0.0247 0.2745 0.9687
0.0403 0.344 1
0.0124 0.661 1
0.0136 0.5 0.5
0.0068 0.5 0.5
0.0587 0.2599 1
0.0148 1 0.5
0.0493 0.3178 1
0.0488 0.9045 0.9004
0.064 0.3096 1
0.0381 1 1
0.0255 0.2884 1
0.0704 1 1
0.0444 1 1
0.1113 0.5 0.5
0.0068 0.8341 1
0.0191 1 0.5
0.0473 1 0.5
0.0068 0.5 0.5
0.0426 0.5169 0.7211
0.0068 0.5 0.5
0.0284 1 1
0.1371 0.7951 1
0.0279 1 1
0.0426 0.5169 0.7211
0.1105 1 1
0.00458364 1 0.5
0.011 1 1
0.1217 1 1
0.048 1 0.5
0.0068 0.5 0.5
0.0593 1 1
0.0068 0.5 0.5
0.008 1 1
0.0124 0.4662 1
0.0169 0.5 0.5
0.0068 0.5 0.5
0.0064 1 1
0.0112 0.5 0.5
0.0068 0.5 0.5
0.0068 0.8051 0.7949
0.0136 0.5 0.5
0.0222 1 0.5
0.0386 0.5 0.5
0.0136 0.5 0.5
0.0238 1 0.5
0.1379 1 1
0.0123 0.4332 0.5
0.0701 0.8841 1
0.0251 0.5 0.5
0.0457 0.26 1
0.0136 0.3761 1
0.0343 0.2854 1
0.0257 1 1
0.0374 0.4555 1
0.0118 0.4395 1
0.1148 1 1
0.0222 1 0.5
0.0128 1 1
0.0552 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC1662 (Onchocerca volvulus),
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