Detailed view for OVOC5567

Basic information

TDR Targets ID: 987153
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 8.8336 | Length (AA): 469 | MW (Da): 54742 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00096  
PF13465  

Gene Ontology

Mouse over links to read term descriptions.
GO:0046872   metal ion binding  
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 311 5wjq (D) 414 666 23.00 0 0.74 0.287225 2.1
2 37 2ept (A) 72 106 34.00 0.000034 0.24 0.345811 0.45
2 31 2eox (A) 8 36 31.00 0.00034 0.23 0.323693 0.17
116 278 5t0u (A) 293 458 30.00 0 1 0.46462 1.44
141 171 2emv (A) 9 38 53.00 0.15 0.89 0.648012 -0.21
197 229 2emm (A) 8 40 58.00 0.000043 0.99 0.684052 0.36
332 380 5d60 (A) 164 212 18.00 0 0 0.273268 -1.58

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127437)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG8474   Meiotic central spindle
Echinococcus granulosus EgrG_000314500   5'partial|oocyte zinc finger protein XlCOF6
Echinococcus granulosus EgrG_001119100   zinc finger C2H2 type
Echinococcus granulosus EgrG_000714900   zinc finger C2H2 type
Echinococcus granulosus EgrG_000979900   zinc finger protein 91
Echinococcus multilocularis EmuJ_000979900   zinc finger protein 91
Echinococcus multilocularis EmuJ_000314500   transcribed hypothetical protein
Loa Loa (eye worm) LOAG_16169   zinc finger protein 121
Loa Loa (eye worm) LOAG_16326   gastrula zinc finger protein XlCGF8.2DB
Loa Loa (eye worm) LOAG_16165   zinc finger protein
Loa Loa (eye worm) LOAG_15831   oocyte zinc finger protein XlCOF2
Loa Loa (eye worm) LOAG_14728   oocyte zinc finger protein XlCOF6
Loa Loa (eye worm) LOAG_14697   hypothetical protein
Loa Loa (eye worm) LOAG_15475   zinc finger protein 429
Loa Loa (eye worm) LOAG_13813   gastrula zinc finger protein XlCGF57.1
Onchocerca volvulus OVOC5567  
Onchocerca volvulus OVOC12012  
Onchocerca volvulus OVOC7845   Zinc finger protein 781 homolog
Schistosoma japonicum Sjp_0059340   ko:K09228 KRAB domain-containing zinc finger protein, putative
Schistosoma japonicum Sjp_0059320   expressed protein
Schistosoma japonicum Sjp_0059330   expressed protein
Schistosoma mansoni Smp_143330   hypothetical protein
Schistosoma mansoni Smp_143320   zinc finger protein
Schmidtea mediterranea mk4.000115.12  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus GABA receptor alpha-6 subunit 453 aa 24.5% 445 aa Compounds References
Rattus norvegicus Glycine receptor subunit alpha-2 452 aa 30.0% 403 aa Compounds References
Rattus norvegicus GABA A receptor alpha-2/beta-2/gamma-2 451 aa 25.7% 440 aa Compounds References
Rattus norvegicus GABA-A receptor; anion channel 467 aa 28.0% 446 aa Compounds References
Rattus norvegicus GABA receptor alpha-5 subunit 464 aa 26.5% 452 aa Compounds References
Rattus norvegicus GABA receptor gamma-1 subunit 465 aa 26.1% 440 aa Compounds References
Rattus norvegicus GABA A receptor alpha-6/beta-2/gamma-2 466 aa 26.8% 437 aa Compounds References
Rattus norvegicus GABA receptor alpha-1 subunit 455 aa 26.0% 438 aa Compounds References
Rattus norvegicus GABA-A receptor; alpha-1/beta-2/gamma-2 455 aa 26.0% 438 aa Compounds References
Rattus norvegicus GABA receptor alpha-2 subunit 451 aa 25.7% 440 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC5567 (Onchocerca volvulus),
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