Detailed view for Rv2586c

Basic information

TDR Targets ID: 9883
Mycobacterium tuberculosis, Probable protein-export membrane protein SecF

Source Database / ID:  Tuberculist 

pI: 10.0008 | Length (AA): 442 | MW (Da): 47014 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 6

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02355   Protein export membrane protein
PF07549   SecD/SecF GG Motif

Gene Ontology

Mouse over links to read term descriptions.
GO:0015627   type II protein secretion system complex  
GO:0009276   Gram-negative-bacterium-type cell wall  
GO:0015450   P-P-bond-hydrolysis-driven protein transmembrane transporter activity  
GO:0008565   protein transporter activity  
GO:0015628   protein secretion by the type II secretion system  
GO:0006886   intracellular protein transport  

Metabolic Pathways

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
58 355 3aqp (A) 442 726 33.00 0 0.93 0.963708 0.45
74 354 5xam (B) 483 754 35.00 0 0.45 0.857247 1.05
85 161 2rrn (A) 469 549 19.00 0 0.91 0.407808 -0.48
282 411 4f1v (A) 1161 1266 41.00 0.37 0.42 0.261618 1.86

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Dormant phase, Dormant phase. hasan murphy
Show/Hide expression data references
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.

Orthologs

Ortholog group members (OG5_133326)

Species Accession Gene Product
Escherichia coli b0409   SecYEG protein translocase auxillary subunit
Mycobacterium leprae ML0488   Probable protein-export membrane protein SecF
Mycobacterium tuberculosis Rv2586c   Probable protein-export membrane protein SecF
Mycobacterium ulcerans MUL_1726   preprotein translocase subunit SecF
Treponema pallidum TP0411   preprotein translocase subunit SecF
Wolbachia endosymbiont of Brugia malayi Wbm0186   preprotein translocase subunit SecF

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv2586c (Mycobacterium tuberculosis), Probable protein-export membrane protein SecF
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