Detailed view for OVOC3711

Basic information

TDR Targets ID: 988402
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 5.0153 | Length (AA): 533 | MW (Da): 60259 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12572  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 216 4k6j (A) 877 1150 8.00 0 0.01 0.491787 -0.53
7 164 2kr0 (A) 77 261 29.00 0.18 0.05 0.310833 1.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131739)

Species Accession Gene Product
Brugia malayi Bm1_32135   hypothetical protein
Caenorhabditis elegans CELE_F26A3.7   Protein F26A3.7
Dictyostelium discoideum DDB_G0284125   hypothetical protein
Drosophila melanogaster Dmel_CG33332   CG33332 gene product from transcript CG33332-RA
Echinococcus granulosus EgrG_000590400   expressed conserved protein
Echinococcus multilocularis EmuJ_000590400   expressed conserved protein
Homo sapiens ENSG00000133114   GPALPP motifs containing 1
Loa Loa (eye worm) LOAG_11112   hypothetical protein
Loa Loa (eye worm) LOAG_07748   hypothetical protein
Mus musculus ENSMUSG00000022008   GPALPP motifs containing 1
Onchocerca volvulus OVOC3711  
Schistosoma japonicum Sjp_0096550   expressed protein
Schistosoma japonicum Sjp_0305980   Conserved hypothetical protein
Schistosoma mansoni Smp_164850   hypothetical protein
Schistosoma mansoni Smp_164860   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 26.0% 285 aa Compounds References
Patiria pectinifera Cdc2 300 aa 26.1% 295 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 27.1% 277 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 26.6% 305 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 25.3% 277 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 28.0% 289 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 25.5% 298 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC3711 (Onchocerca volvulus),
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