pI: 9.6926 |
Length (AA): 494 |
MW (Da): 56144 |
Paralog Number:
8169
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
164 | 999 | 1tr2 (A) | 21 | 894 | 11.00 | 0 | 1 | 0.715416 | 0.55 |
776 | 872 | 5xg2 (A) | 417 | 758 | 33.00 | 0.32 | 0.19 | 0.329489 | -0.5 |
793 | 875 | 2qih (A) | 577 | 654 | 15.00 | 0 | 0.06 | 0.0982216 | -0.41 |
851 | 1018 | 4uos (A) | 3 | 175 | 15.00 | 0.35 | 0.01 | 0.34141 | -1.24 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Muscarinic acetylcholine receptor | 466 aa | 26.9% | 505 aa | Compounds | References |
Bos taurus | Dopamine D2 receptor | 444 aa | 22.8% | 479 aa | Compounds | References |
Cavia porcellus | Histamine H1 receptor | 488 aa | 26.5% | 486 aa | Compounds | References |
Rattus norvegicus | Dopamine D2 receptor | 444 aa | 23.4% | 474 aa | Compounds | References |
Rattus norvegicus | Adenosine A2b receptor | 332 aa | 26.1% | 280 aa | Compounds | References |
Cavia porcellus | Muscarinic receptor 2 | 466 aa | 26.7% | 495 aa | Compounds | References |
Rattus norvegicus | Dopamine D3 receptor | 446 aa | 22.8% | 478 aa | Compounds | References |
Sus scrofa | Muscarinic acetylcholine receptor M2 | 466 aa | 26.7% | 505 aa | Compounds | References |
Rattus norvegicus | Platelet activating factor receptor | 341 aa | 22.6% | 314 aa | Compounds | References |
Rattus norvegicus | Histamine H1 receptor | 486 aa | 23.8% | 492 aa | Compounds | References |
Chilo suppressalis | TyR1 | 478 aa | 21.4% | 462 aa | Compounds | References |
Canis lupus familiaris | Dopamine D2 receptor | 443 aa | 23.8% | 483 aa | Compounds | References |
Rattus norvegicus | Muscarinic acetylcholine receptor M2 | 466 aa | 26.9% | 505 aa | Compounds | References |
Cavia porcellus | Mu opioid receptor | 98 aa | 31.2% | 96 aa | Compounds | References |
Sus scrofa | Serotonin 1b (5-HT1b) receptor | 150 aa | 28.2% | 124 aa | Compounds | References |
Bos taurus | 5-hydroxytryptamine 1D receptor | 119 aa | 30.0% | 100 aa | Compounds | References |
Rattus norvegicus | Adenosine receptor | 332 aa | 26.1% | 280 aa | Compounds | References |