Detailed view for OVOC11086

Basic information

TDR Targets ID: 988735
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 4.5805 | Length (AA): 209 | MW (Da): 24637 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00641  

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
25 61 1n0z (A) 4 40 41.00 0.00037 0.76 0.641992 0.57
85 115 2k1p (A) 65 95 58.00 0.062 0.93 0.798047 0.42
87 142 3b08 (B) 193 242 24.00 0 0.41 0.499149 -0.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131371)

Species Accession Gene Product
Babesia bovis BBOV_I000380   conserved hypothetical protein
Brugia malayi Bm1_26850   Zn-finger in Ran binding protein and others containing protein
Caenorhabditis elegans CELE_Y25C1A.8   Protein Y25C1A.8, isoform A
Drosophila melanogaster Dmel_CG3732   CG3732 gene product from transcript CG3732-RA
Echinococcus granulosus EgrG_001117200   zinc finger protein Ran binding
Echinococcus multilocularis EmuJ_001117200   zinc finger protein Ran binding
Homo sapiens ENSG00000132485   zinc finger, RAN-binding domain containing 2
Loa Loa (eye worm) LOAG_07588   hypothetical protein
Mus musculus ENSMUSG00000028180   zinc finger, RAN-binding domain containing 2
Neospora caninum NCLIV_061180   zinc finger, putative
Onchocerca volvulus OVOC11086  
Plasmodium berghei PBANKA_1005900   zinc finger Ran-binding domain-containing protein 2, putative
Plasmodium falciparum PF3D7_0408300   zinc finger Ran-binding domain-containing protein 2, putative
Plasmodium knowlesi PKNH_0306300   zinc finger Ran-binding domain-containing protein 2, putative
Plasmodium vivax PVX_000830   hypothetical protein, conserved
Plasmodium yoelii PY02236   hypothetical protein
Schistosoma japonicum Sjp_0086520   Zinc finger Ran-binding domain-containing protein 2, putative
Schistosoma mansoni Smp_082560.1   zinc finger protein
Schmidtea mediterranea mk4.000124.09  
Schmidtea mediterranea mk4.001196.00  
Toxoplasma gondii TGME49_219300   ran binding protein
Theileria parva TP02_0913   hypothetical protein, conserved

Essentiality

OVOC11086 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1005900 Plasmodium berghei Dispensable plasmo
TGME49_219300 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0304 0.2781 0.3438
0.0445 0.3486 0.3483
0.0129 0.2501 0.2977
0.0516 0.3074 0
0.0228 0.2543 0.3256
0.0521 0.34 0.3474
0.0203 0.2647 0
0.0486 0.3438 0.3438
0.0455 0.2669 0.3438
0.0311 0.3264 0.2732
0.038 0.3496 0.3438
0.0568 0.3496 0.3492
0.0288 0.352 0.351
0.0505 0.3488 0.3488
0.0259 0.2982 0.3419
0.0142 0.3105 0.2918
0.033 0.3178 0.3077
0.0037 0.2654 0
0.0123 0.293 0
0.0176 0.3337 0.3134
0.0273 0.2964 0.3346
0.0282 0.3434 0.1843
0.0401 0.2719 0.2719
0.0354 0.345 0.3438
0.0492 0.3407 0.2911
0.0313 0.3521 0.3495
0.0058 0.3143 0
0.0323 0.3234 0.3472
0.0311 0.3239 0
0.0355 0.3433 0.3438
0.0029 0.2659 0
0.0134 0.2618 0.1302
0.0339 0.3438 0.3438
0.0209 0.3348 0.3256
0.0351 0.3239 0
0.0129 0.2501 0.2977
0.0566 0.3159 0.3518
0.0133 0.3027 0.347
0.0422 0.2829 0.3479
0.0044 0.2766 0
0.0022 0.2793 0.2793
0.0133 0.3027 0.347
0.0201 0.282 0.282
0.0443 0.334 0.3311
0.0175 0.3372 0.3372
0.0138 0.3349 0.3259
0.008 0.3346 0.3346
0.0286 0.3142 0
0.0207 0.2745 0.3188
0.0466 0.2741 0
0.0544 0.3142 0.2546
0.0489 0.306 0.306
0.0138 0.3225 0.3095
0.0311 0.3115 0
0.0228 0.3438 0.3438
0.0273 0.2964 0.3346
0.0219 0.2903 0.3371
0.0127 0.3436 0.3338
0.0071 0.2779 0.2779
0.0111 0.2753 0.2718
0.0521 0.3438 0.3438
0.0096 0.336 0.3336
0.0037 0.2654 0
0.0138 0.3349 0.3259
0.0209 0.3348 0.3256
0.0414 0.3472 0.3443
0.0219 0.2903 0.3371
0.0219 0.2903 0.3371
0.0285 0.3113 0.3113
0.0128 0.3018 0
0.0422 0.2829 0.3479
0.0353 0.3507 0.3507
0.0306 0.2511 0.3487
0.0492 0.3407 0.2911
0.0261 0.3061 0.2965
0.0456 0.3409 0.3409
0.0247 0.2531 0.1051
0.0254 0.2634 0.3325
0.0113 0.3091 0.3157
0.0304 0.3509 0.3483
0.0133 0.3394 0
0.0498 0.3475 0.3438
0.0273 0.2964 0.3346
0.0123 0.3321 0.3321
0.0558 0.2532 0.3508
0.0395 0.3288 0.2964
0.0579 0.3402 0.3402
0.0501 0.3438 0.3438
0.0336 0.3214 0.3214
0.0382 0.3427 0.3427
0.0155 0.2818 0.2818
0.0363 0.3359 0
0.0349 0.3468 0.3438
0.0375 0.3505 0.3505
0.0307 0.3438 0.3332
0.0189 0.3334 0.2517
0.0331 0.3483 0.3438
0.041 0.3449 0.3438
0.0043 0.2685 0
0.0247 0.2525 0.1033
0.0254 0.3313 0
0.032 0.3438 0.3438
0.0274 0.296 0.3491
0.0319 0.3438 0.3438
0.0469 0.3466 0.3438
0.0327 0.3261 0.3261
0.0034 0.2564 0.2982
0.0245 0.258 0.347
0.032 0.3438 0.3438
0.0254 0.2634 0.3325
0.0102475 0.280464 0
0.0313 0.285 0.3438
0.032 0.3438 0.3438
0.0036 0.2882 0
0.0258 0.3422 0.1637
0.017 0.2828 0
0.0311 0.3264 0.2732
0.0219 0.2903 0.3371
0.0127 0.2969 0
0.0532 0.2616 0.2223
0.043 0.2664 0
0.0382 0.3427 0.3427
0.0129 0.2501 0.2977
0.0453 0.3529 0.351
0.0273 0.2964 0.3346
0.0416 0.3472 0.3472
0.0347 0.3424 0
0.0219 0.2903 0.3371
0.0354 0.345 0.3438
0.0082 0.3426 0
0.0048 0.2849 0.1413
0.0085 0.2648 0
0.0521 0.3438 0.3438
0.054 0.2542 0.2542
0.049 0.3157 0.2468
0.0337 0.3431 0.2804
0.0229 0.3337 0.3438
0.0256 0.2563 0.1143
0.013 0.3049 0
0.0212 0.3148 0.3042
0.0203 0.2977 0.2253
0.0063 0.3204 0.3204
0.0521 0.34 0.3474
0.0129 0.2612 0.1285
0.014 0.315 0.2558
0.0024 0.2575 0
0.0349 0.3246 0.3246
0.0361 0.3397 0.3185
0.0085 0.2846 0.2846
0.0418 0.3438 0.3438
0.0256 0.2563 0.1143
0.0176 0.3438 0.3438
0.0296 0.3477 0.3438
0.0068 0.264 0.3073
0.0117 0.2688 0.338
0.0131 0.2515 0.2515
0.0214 0.2745 0
0.0273 0.3426 0.314
0.0209 0.3348 0.3256
0.0476 0.3438 0.3438
0.0343 0.3529 0.3529
0.0343 0.3464 0.3438
0.0037 0.2654 0
0.0396 0.3457 0.3438
0.0349 0.3246 0.3246
0.016 0.3422 0.3418
0.0331 0.3483 0.3438
0.0285 0.3113 0.3113
0.0577 0.3352 0.2644
0.0285 0.3113 0.3113
0.0093 0.2786 0.3438
0.0396 0.3457 0.3438
0.0311 0.3115 0
0.0259 0.3438 0
0.0273 0.3426 0.314
0.0577 0.3257 0.3129
0.049 0.3322 0
0.0368 0.2849 0
0.0492 0.35 0.35
0.0169 0.2843 0.1911
0.0273 0.2964 0.3346
0.0445 0.3486 0.3483
0.0334 0.3513 0.3504
0.0455 0.2669 0.3438
0.0353 0.3484 0.3468
0.0381 0.3359 0
0.0113 0.3091 0.3157
0.0109 0.3407 0
0.0307 0.3438 0.3332
0.0304 0.3509 0.3483
0.00665706 0.325018 0
0.0534 0.3528 0.3504
0.0152 0.2714 0
0.0138 0.2666 0.1437
0.0416 0.3472 0.3472
0.0092 0.3412 0.3255
0.049 0.3157 0.2468
0.0219 0.2903 0.3371
0.0489 0.345 0.345
0.0505 0.3488 0.3488
0.0365 0.2915 0.2915
0.0378 0.3425 0.222
0.0469 0.3466 0.3438
0.0445 0.3486 0.3483
0.0023 0.3148 0.3148
0.0164 0.3128 0.2736
0.0542 0.3099 0.2581
0.0219 0.2903 0.3371
0.0129 0.3347 0.3347
0.012 0.3388 0.3352
0.0509 0.3457 0.3438
0.0476 0.3254 0
0.0185 0.3331 0.2902
0.0155 0.2763 0.2763
0.0255 0.321 0.2543
0.0261 0.3061 0.2965
0.0293 0.2686 0.3136
0.0448 0.3057 0
0.0459 0.3397 0.3322
0.0504 0.3096 0
0.0394 0.2708 0.3448
0.0355 0.3433 0.3438
0.0232 0.3204 0.318
0.032 0.3438 0.3438
0.0076 0.2765 0
0.0232 0.3204 0.318
0.0443 0.334 0.3311
0.0396 0.3457 0.3438
0.0493 0.352 0.3478
0.0432 0.3438 0.3438
0.0247 0.3217 0.2952
0.0319 0.3391 0.3391
0.0534 0.3528 0.3504
0.0039 0.2989 0
0.012 0.3388 0.3352
0.0493 0.352 0.3478
0.0347 0.3424 0
0.0273 0.2964 0.3346
0.0521 0.34 0.3474
0.0375 0.3505 0.3505
0.0467 0.305 0
0.0493 0.352 0.3478
0.0488 0.3448 0.3445
0.0349 0.3246 0.3246
0.0043 0.3043 0
0.0448 0.3057 0
0.054 0.3513 0.3455
0.0396 0.3457 0.3438
0.0139 0.2681 0.1477
0.0117 0.2688 0.338
0.0238 0.3438 0
0.0189 0.3334 0.2517
0.0343 0.3464 0.3438
0.0552 0.2987 0.3369
0.0056 0.2663 0
0.0579 0.3385 0.3381
0.0538 0.269 0.3499
0.0127 0.3436 0.3338
0.0179 0.2669 0.3407
0.041 0.3428 0.2346
0.0445 0.3486 0.3483
0.0433 0.3324 0.2662
0.0538 0.269 0.3499
0.0138 0.3225 0.3095
0.0445 0.3486 0.3483
0.0556 0.3051 0.3051
0.0527 0.3375 0
0.0533 0.2913 0
0.0451 0.324 0.3495
0.0036 0.2947 0
0.0493 0.352 0.3478
0.0403 0.3537 0.353
0.0368 0.2526 0.3374
0.0219 0.2903 0.3371
0.0538 0.269 0.3499

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier OVOC11086 (Onchocerca volvulus),
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