Detailed view for OVOC6963

Basic information

TDR Targets ID: 988875
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 8.5342 | Length (AA): 509 | MW (Da): 58634 | Paralog Number: 9

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 94 4tql (A) 115 213 17.00 0.53 0.22 0.916859 -1.03
14 74 3cux (A) 34 96 36.00 0.83 0.21 0.739929 0.39

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130223)

Species Accession Gene Product
Brugia malayi Bm1_37120   hypothetical protein
Brugia malayi Bm1_23145   gag protein
Brugia malayi Bm1_02355   hypothetical protein
Brugia malayi Bm1_15890   hypothetical protein
Brugia malayi Bm1_25405   hypothetical protein
Brugia malayi Bm1_15120   hypothetical protein
Brugia malayi Bm1_05250   hypothetical protein
Brugia malayi Bm1_25320   hypothetical protein
Brugia malayi Bm1_23405   gag protein
Brugia malayi Bm1_19165   gag protein
Brugia malayi Bm1_12940   hypothetical protein
Brugia malayi Bm1_21310   hypothetical protein
Brugia malayi Bm1_26005   E239.9-1
Brugia malayi Bm1_39405   hypothetical protein
Brugia malayi Bm1_28175   hypothetical protein
Brugia malayi Bm1_24265   gag protein
Brugia malayi Bm1_03185   gag protein
Brugia malayi Bm1_40120   hypothetical protein
Brugia malayi Bm1_16100   gag protein
Brugia malayi Bm1_40115   hypothetical protein
Brugia malayi Bm1_28535   hypothetical protein
Brugia malayi Bm1_32270   hypothetical protein
Brugia malayi Bm1_10580   hypothetical protein
Brugia malayi Bm1_24450   hypothetical protein
Brugia malayi Bm1_37125   hypothetical protein
Brugia malayi Bm1_08300   hypothetical protein
Brugia malayi Bm1_30885   gag protein
Brugia malayi Bm1_13465   gag protein
Brugia malayi Bm1_54985   hypothetical protein
Brugia malayi Bm1_30040   gag protein
Brugia malayi Bm1_25350   hypothetical protein
Brugia malayi Bm1_29190   gag protein
Brugia malayi Bm1_21720   hypothetical protein
Brugia malayi Bm1_24380   hypothetical protein
Brugia malayi Bm1_07450   hypothetical protein
Brugia malayi Bm1_03380   hypothetical protein
Brugia malayi Bm1_13020   hypothetical protein
Brugia malayi Bm1_36450   hypothetical protein
Brugia malayi Bm1_24745   hypothetical protein
Brugia malayi Bm1_00950   hypothetical protein
Brugia malayi Bm1_34830   gag protein
Brugia malayi Bm1_18645   hypothetical protein
Brugia malayi Bm1_54075   gag protein
Brugia malayi Bm1_23420   hypothetical protein
Brugia malayi Bm1_21715   gag protein
Brugia malayi Bm1_29195   hypothetical protein
Brugia malayi Bm1_06045   hypothetical protein
Brugia malayi Bm1_02620   hypothetical protein
Brugia malayi Bm1_03155   gag protein
Brugia malayi Bm1_29340   gag protein
Brugia malayi Bm1_19170   hypothetical protein
Brugia malayi Bm1_28575   hypothetical protein
Loa Loa (eye worm) LOAG_07111   hypothetical protein
Loa Loa (eye worm) LOAG_14282   hypothetical protein
Loa Loa (eye worm) LOAG_05661   hypothetical protein
Loa Loa (eye worm) LOAG_13562   hypothetical protein
Loa Loa (eye worm) LOAG_16199   hypothetical protein
Loa Loa (eye worm) LOAG_10994   zinc knuckle family protein
Onchocerca volvulus OVOC12368  
Onchocerca volvulus OVOC12909  
Onchocerca volvulus OVOC12502  
Onchocerca volvulus OVOC8731  
Onchocerca volvulus OVOC12951  
Onchocerca volvulus OVOC11329  
Onchocerca volvulus OVOC12917  
Onchocerca volvulus OVOC1987  
Onchocerca volvulus OVOC6963  
Onchocerca volvulus OVOC3095  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Cytochrome P450 2E1 493 aa 24.3% 507 aa Compounds References
Canis familiaris Cytochrome P450 2B11 494 aa 22.5% 479 aa Compounds References
Thlaspi arvense Cytochrome P450 71B1 496 aa 24.8% 435 aa Compounds References
Rattus norvegicus Cytochrome P450 3A1 504 aa 27.2% 408 aa Compounds References
Oryctolagus cuniculus Cytochrome P450 2B4 491 aa 23.8% 479 aa Compounds References
Rattus norvegicus Cytochrome P450 2A2 492 aa 23.7% 494 aa Compounds References
Rattus norvegicus Cytochrome P450 2C23 494 aa 23.3% 459 aa Compounds References
Rattus norvegicus Cytochrome P450 2D2 500 aa 25.4% 426 aa Compounds References
Rattus norvegicus Cytochrome P450c11B3 498 aa 21.9% 416 aa Compounds References
Rattus norvegicus Cytochrome P450 2B1 491 aa 22.5% 418 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier OVOC6963 (Onchocerca volvulus),
Title for this comment
Comment