Detailed view for OVOC11519

Basic information

TDR Targets ID: 989052
Onchocerca volvulus, Solute carrier family 35 member E1 homolog
Source Database / ID:  Wormbase Parasite  

pI: 8.689 | Length (AA): 41 | MW (Da): 4735 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00892  
PF03151  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 307 5y78 (A) 107 400 27.00 0 0.98 1.15646 -0.43
291 382 5d4b (A) 249 333 34.00 0.55 0.11 0.267326 1.82

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128059)

Species Accession Gene Product
Arabidopsis thaliana AT1G61800   glucose-6-phosphate/phosphate translocator 2
Arabidopsis thaliana AT3G01550   phosphoenolpyruvate (pep)/phosphate translocator 2
Arabidopsis thaliana AT5G17630   nucleotide/sugar transporter family protein
Arabidopsis thaliana AT5G54800   glucose-6-phosphate/phosphate translocator 1
Arabidopsis thaliana AT5G33320   phosphoenolpyruvate/phosphate translocator 1
Babesia bovis BBOV_I004960   triose phosphate/phosphate translocator, putative
Babesia bovis BBOV_I004970   triose or hexose phosphate/phosphate translocator, putative
Babesia bovis BBOV_I004950   triose or hexose phosphate/phosphate translocator, putative
Brugia malayi Bm1_00075   Solute carrier family 35 member E1
Candida albicans CaO19.11675   Member of triose phosphate translocator family
Candida albicans CaO19.4199   Member of triose phosphate translocator family
Drosophila melanogaster Dmel_CG14621   CG14621 gene product from transcript CG14621-RD
Echinococcus granulosus EgrG_000172800   solute carrier family 35 member e1 protein
Echinococcus multilocularis EmuJ_000172800   solute carrier family 35 member e1 protein
Homo sapiens ENSG00000127526   solute carrier family 35, member E1
Loa Loa (eye worm) LOAG_12250   hypothetical protein
Loa Loa (eye worm) LOAG_05921   hypothetical protein
Mus musculus ENSMUSG00000019731   solute carrier family 35, member E1
Neospora caninum NCLIV_026210   hypothetical protein
Oryza sativa 4345334   Os08g0344600
Oryza sativa 4337941   Os05g0170900
Oryza sativa 4338191   Os05g0241200
Oryza sativa 4344834   Os08g0187800
Oryza sativa 4327644   Os01g0172100
Oryza sativa 4346653   Os09g0297400
Oryza sativa 4343418   Os07g0523600
Onchocerca volvulus OVOC11519   Solute carrier family 35 member E1 homolog
Plasmodium berghei PBANKA_1107900   triose phosphate transporter
Plasmodium falciparum PF3D7_0508300   triose phosphate transporter
Plasmodium knowlesi PKNH_1025300   triose phosphate transporter, putative
Plasmodium vivax PVX_097975   triose/hexose phosphate phosphate translocator, putative
Plasmodium yoelii PY00389   Arabidopsis thaliana At5g54800/MBG8_6-related
Saccharomyces cerevisiae YOR307C   Sly41p
Schmidtea mediterranea mk4.000004.07   Solute carrier family 35 member E1
Toxoplasma gondii TGME49_261070   apicoplast triosephosphate translocator APT1
Theileria parva TP03_0536   phosphate translocator, putative

Essentiality

OVOC11519 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_261070 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC11519 (Onchocerca volvulus), Solute carrier family 35 member E1 homolog
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