Detailed view for OVOC4365

Basic information

TDR Targets ID: 989302
Onchocerca volvulus, Mitochondrial inner membrane protein homolog

Source Database / ID:  Wormbase Parasite  

pI: 10.1883 | Length (AA): 431 | MW (Da): 48293 | Paralog Number: 8169

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 8

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
235 470 5nnv (D) 254 923 18.00 0 0.97 0.415114 0.23
254 427 5h7a (C) 40 195 34.00 0.11 0.78 0.399314 0.78
257 437 4uos (A) 2 183 24.00 0.075 0.87 0.591747 -1.05
258 446 5vjt (A) 7 195 15.00 0 0.09 0.425069 -1.13
439 659 4tql (A) 9 227 8.00 0.81 0 0.380459 -0.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Sphingosine 1-phosphate receptor 1 383 aa 22.2% 342 aa Compounds References
Rattus norvegicus Lysophosphatidic acid receptor Edg-2 364 aa 23.2% 340 aa Compounds References
Rattus norvegicus Bradykinin B2 receptor 396 aa 23.7% 317 aa Compounds References
Rattus norvegicus Melanocortin receptor 4 332 aa 25.3% 320 aa Compounds References
Rattus norvegicus Lysophosphatidic acid receptor 1/lysophosphatidic acid receptor 3 354 aa 25.2% 325 aa Compounds References
Gallus gallus Oxytocin-like receptor 391 aa 25.4% 374 aa Compounds References
Rattus norvegicus Beta-3 adrenergic receptor 400 aa 34.8% 328 aa Compounds References
Macaca mulatta Mu-type opioid receptor 400 aa 23.4% 334 aa Compounds References
Rattus norvegicus Dopamine D4 receptor 387 aa 31.2% 349 aa Compounds References
Oryctolagus cuniculus Neurokinin 2 receptor 384 aa 22.5% 334 aa Compounds References
Rattus norvegicus Melanocortin receptor 5 325 aa 24.4% 349 aa Compounds References
Rattus norvegicus Sphingosine 1-phosphate receptor 2 352 aa 23.8% 353 aa Compounds References
Oryctolagus cuniculus Growth hormone secretagogue receptor type 1 366 aa 20.5% 327 aa Compounds References
Bos taurus Vasopressin V2 receptor 370 aa 24.0% 321 aa Compounds References
Cricetulus griseus 5-hydroxytryptamine receptor 422 aa 29.7% 407 aa Compounds References
Sus scrofa Vasopressin V2 receptor 370 aa 23.7% 329 aa Compounds References
Gallus gallus Melatonin receptor 346 aa 24.8% 315 aa Compounds References
Bos taurus Beta-2 adrenergic receptor 418 aa 34.2% 345 aa Compounds References
Macaca fascicularis C-C chemokine receptor type 3 355 aa 20.4% 313 aa Compounds References
Rattus norvegicus Gonadotropin-releasing hormone receptor 327 aa 24.3% 288 aa Compounds References
Canis lupus familiaris Uncharacterized protein 335 aa 21.1% 285 aa Compounds References
Rattus norvegicus Trace amine-associated receptor 7b 358 aa 31.0% 319 aa Compounds References
Cavia porcellus Beta-2 adrenergic receptor 418 aa 33.5% 346 aa Compounds References
Rattus norvegicus Melatonin receptor 1B 364 aa 21.9% 356 aa Compounds References
Cavia porcellus Cholecystokinin A receptor 430 aa 24.5% 363 aa Compounds References
Rattus norvegicus C-X-C chemokine receptor type 4 349 aa 22.3% 328 aa Compounds References
Cavia porcellus Mu opioid receptor 98 aa 34.1% 85 aa Compounds References
Rattus norvegicus Melanocortin receptor 3 323 aa 24.1% 319 aa Compounds References
Rattus norvegicus Serotonin 1a (5-HT1a) receptor 422 aa 30.5% 383 aa Compounds References
Rattus norvegicus Serotonin 1 (5-HT1) receptor 366 aa 33.2% 365 aa Compounds References
Rattus norvegicus C5a anaphylatoxin chemotactic receptor 352 aa 23.1% 342 aa Compounds References
Rattus norvegicus Serotonin 5b (5-HT5b) receptor 370 aa 34.8% 310 aa Compounds References
Oryctolagus cuniculus Adenosine A1 receptor 328 aa 29.1% 340 aa Compounds References
Macaca mulatta Melanin-concentrating hormone receptor 1 388 aa 22.6% 358 aa Compounds References
Sus scrofa Ghrelin receptor 366 aa 21.0% 328 aa Compounds References
Oryctolagus cuniculus Bradykinin B2 receptor 367 aa 25.5% 325 aa Compounds References
Mesocricetus auratus Neurokinin 2 receptor 384 aa 24.3% 412 aa Compounds References
Rattus norvegicus Neurokinin 2 receptor 390 aa 23.6% 368 aa Compounds References
Cavia porcellus Bradykinin B2 receptor 372 aa 23.9% 339 aa Compounds References
Rattus norvegicus Thyrotropin-releasing hormone receptor 2 352 aa 24.5% 318 aa Compounds References
Rattus norvegicus Serotonin 1f (5-HT1f) receptor 366 aa 33.2% 365 aa Compounds References
Gorilla gorilla Serotonin 1b (5-HT1b) receptor 390 aa 36.8% 348 aa Compounds References
Rattus norvegicus Adenosine A3 receptor 320 aa 25.0% 312 aa Compounds References
Cavia porcellus Adenosine A1 receptor 326 aa 28.8% 340 aa Compounds References
Oryctolagus cuniculus Bradykinin B1 receptor 352 aa 21.7% 336 aa Compounds References
Bos taurus 5-hydroxytryptamine 1D receptor 119 aa 40.2% 102 aa Compounds References
Cavia porcellus mu/kappa opioid receptor 380 aa 25.4% 334 aa Compounds References
Rattus norvegicus Neurotensin receptor 1 424 aa 22.1% 399 aa Compounds References
Rattus norvegicus Histamine H2 receptor 358 aa 32.1% 368 aa Compounds References
Bos taurus Uncharacterized protein 403 aa 26.5% 358 aa Compounds References
Macaca mulatta Sphingosine 1-phosphate receptor 1 382 aa 21.4% 383 aa Compounds References
Macaca fascicularis Melanin-concentrating hormone receptor 1 249 aa 21.5% 289 aa Compounds References
Cavia porcellus Histamine H2 receptor 359 aa 32.9% 353 aa Compounds References
Macaca fascicularis G-protein coupled receptor 119 335 aa 21.7% 382 aa Compounds References
Macaca fascicularis B1 bradykinin receptor 352 aa 22.9% 341 aa Compounds References
Cricetulus griseus 5-hydroxytryptamine receptor 1B 386 aa 37.2% 333 aa Compounds References
Rattus norvegicus Purinergic receptor P2Y12 343 aa 19.6% 372 aa Compounds References
Rattus norvegicus Vasopressin V2 receptor 371 aa 24.1% 332 aa Compounds References
Cavia porcellus Adenosine A2a receptor 409 aa 27.5% 356 aa Compounds References
Rattus norvegicus Nociceptin/mu opioid receptor 398 aa 23.1% 334 aa Compounds References
Oryctolagus cuniculus Adenosine A3 receptor 319 aa 24.0% 321 aa Compounds References
Mesocricetus auratus Beta-2 adrenergic receptor 418 aa 33.7% 344 aa Compounds References
Sus scrofa Serotonin 4 (5-HT4) receptor 402 aa 29.4% 378 aa Compounds References
Rattus norvegicus Melanin-concentrating hormone receptor 1 360 aa 23.6% 331 aa Compounds References
Rattus norvegicus Serotonin 1B/1D receptor 374 aa 34.7% 352 aa Compounds References
Bos taurus Adenosine receptor A3 317 aa 25.0% 336 aa Compounds References
Rattus norvegicus Serotonin 1d (5-HT1d) receptor 374 aa 34.7% 352 aa Compounds References
Rattus norvegicus Adenosine A2b receptor 332 aa 28.1% 345 aa Compounds References
Cavia porcellus Kappa opioid receptor 380 aa 25.4% 334 aa Compounds References
Rattus norvegicus Somatostatin receptor 1 391 aa 26.2% 343 aa Compounds References
Canis lupus familiaris Beta-2 adrenergic receptor 415 aa 32.4% 358 aa Compounds References
Rattus norvegicus Serotonin 1b (5-HT1b) receptor 386 aa 37.2% 333 aa Compounds References
Bos taurus Mu opioid receptor 401 aa 23.4% 334 aa Compounds References
Rattus norvegicus Adenosine A2a receptor 410 aa 27.9% 340 aa Compounds References
Rattus norvegicus Adrenergic receptor beta 400 aa 34.8% 328 aa Compounds References
Macaca mulatta Trace amine-associated receptor 1 338 aa 29.6% 345 aa Compounds References
Rattus norvegicus Trace amine-associated receptor 1 332 aa 32.0% 328 aa Compounds References
Canis lupus familiaris Bradykinin B1 receptor 350 aa 20.6% 316 aa Compounds References
Rattus norvegicus Serotonin (5-HT) receptor 386 aa 37.2% 333 aa Compounds References
Rattus norvegicus Lysophosphatidic acid receptor Edg-7 354 aa 25.2% 325 aa Compounds References
Rattus norvegicus Histamine H4 receptor 391 aa 27.3% 363 aa Compounds References
Rattus norvegicus Gastrin releasing peptide receptor 384 aa 21.9% 370 aa Compounds References
Gallus gallus Adenosine A1 receptor 324 aa 27.9% 315 aa Compounds References
Macaca mulatta C-X-C chemokine receptor type 4 352 aa 22.1% 322 aa Compounds References
Rattus norvegicus Nociceptin receptor 367 aa 23.8% 349 aa Compounds References
Canis lupus familiaris Sphingosine-1-phosphate receptor 1 381 aa 21.0% 357 aa Compounds References
Xenopus laevis Melatonin receptor 1C 420 aa 24.7% 340 aa Compounds References
Rattus norvegicus Mu opioid receptor 398 aa 23.1% 334 aa Compounds References
Macaca mulatta Gonadotropin-releasing hormone receptor 59 aa 27.1% 48 aa Compounds References
Cavia porcellus Serotonin 4 (5-HT4) receptor 388 aa 29.6% 395 aa Compounds References
Macaca mulatta C-C chemokine receptor type 3 355 aa 20.1% 314 aa Compounds References
Macaca mulatta Urotensin II receptor 389 aa 23.9% 351 aa Compounds References
Gallus gallus Melatonin receptor 1B 289 aa 21.9% 333 aa Compounds References
Danio rerio Mu opioid receptor-like OR2 384 aa 22.5% 347 aa Compounds References
Rattus norvegicus Kappa opioid receptor 380 aa 25.8% 337 aa Compounds References
Cavia porcellus Serotonin 1d (5-HT1d) receptor 376 aa 35.8% 344 aa Compounds References
Bos taurus Rhodopsin 348 aa 20.4% 318 aa Compounds References
Rattus norvegicus Free fatty acid receptor 4 361 aa 21.2% 312 aa Compounds References
Rattus norvegicus Beta-2 adrenergic receptor 418 aa 32.9% 347 aa Compounds References
Cavia porcellus Neurokinin 2 receptor 402 aa 22.8% 329 aa Compounds References
Rattus norvegicus Adenosine A2 receptor 410 aa 27.9% 340 aa Compounds References
Cavia porcellus Histamine H4 receptor 389 aa 26.0% 369 aa Compounds References
Rattus norvegicus Serotonin 5a (5-HT5a) receptor 357 aa 32.8% 329 aa Compounds References
Rattus norvegicus Serotonin 4 (5-HT4) receptor 406 aa 30.7% 348 aa Compounds References
Rattus norvegicus Adenosine receptor 332 aa 28.1% 345 aa Compounds References
Cavia porcellus Nociceptin receptor 370 aa 24.9% 349 aa Compounds References
Rattus norvegicus Ghrelin receptor 364 aa 21.2% 325 aa Compounds References
Canis lupus familiaris Adenosine receptor A3 314 aa 25.7% 331 aa Compounds References
Macaca mulatta B1 bradykinin receptor 352 aa 22.9% 341 aa Compounds References
Cavia porcellus Mu-opioid receptor 400 aa 22.8% 334 aa Compounds References
Rattus norvegicus Oxytocin receptor 388 aa 24.0% 346 aa Compounds References
Chlorocebus aethiops Dopamine D3 receptor 400 aa 29.8% 366 aa Compounds References
Sus scrofa Serotonin 1d (5-HT1d) receptor 291 aa 37.2% 293 aa Compounds References
Ovis aries Ghrelin receptor 366 aa 20.5% 327 aa Compounds References
Bos taurus Neurokinin 2 receptor 384 aa 22.6% 371 aa Compounds References
Carassius auratus Dopamine D1 receptor 363 aa 32.0% 362 aa Compounds References
Rattus norvegicus Platelet activating factor receptor 341 aa 21.5% 353 aa Compounds References
Rattus norvegicus Neuromedin B receptor 390 aa 21.8% 357 aa Compounds References

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC4365 (Onchocerca volvulus), Mitochondrial inner membrane protein homolog
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