Detailed view for OVOC6461

Basic information

TDR Targets ID: 989385
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 7.6018 | Length (AA): 718 | MW (Da): 81124 | Paralog Number: 3

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00581  

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0004725   protein tyrosine phosphatase activity  
GO:0006470   protein amino acid dephosphorylation  
GO:0000087   M phase of mitotic cell cycle  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
320 496 4wh9 (A) 382 551 34.00 0 1 0.71098 -0.42
339 486 3op3 (A) 305 446 39.00 0 1 0.662922 -0.13
339 488 4wh9 (A) 401 544 38.00 0 1 0.642678 -0.33

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127845)

Species Accession Gene Product
Brugia malayi Bm1_12850   Rhodanese-like domain containing protein
Brugia malayi Bm1_12860   Rhodanese-like domain containing protein
Candida albicans CaO19.3071   similar to A.nidulans mitotic inducer phosphatase NIMT/CDC25 and to S. cerevisiae MIH1 (YMR036C)
Candida albicans CaO19.1812   almost identical to C terminus of CaP19.3071, which is similar to A.nidulans mitotic inducer phosphatase NIMT/CDC25 and to S. ce
Caenorhabditis elegans CELE_K06A5.7   Protein CDC-25.1
Caenorhabditis elegans CELE_ZK637.11   Protein CDC-25.3
Caenorhabditis elegans CELE_F16B4.8   Protein CDC-25.2
Dictyostelium discoideum DDB_G0283617   rhodanese-like domain-containing protein
Drosophila melanogaster Dmel_CG1395   string
Drosophila melanogaster Dmel_CG4965   twine
Echinococcus granulosus EgrG_001174300   m phase inducer phosphatasecdc25
Entamoeba histolytica EHI_134760   rodhanase-like domain containing protein
Entamoeba histolytica EHI_185610   rodhanase-like domain containing protein
Entamoeba histolytica EHI_160700   rodhanase-like domain containing protein
Echinococcus multilocularis EmuJ_001174300   m phase inducer phosphatase(cdc25)
Homo sapiens ENSG00000158402   cell division cycle 25C
Homo sapiens ENSG00000164045   cell division cycle 25A
Homo sapiens ENSG00000101224   cell division cycle 25B
Loa Loa (eye worm) LOAG_06630   hypothetical protein
Loa Loa (eye worm) LOAG_08608   hypothetical protein
Loa Loa (eye worm) LOAG_08606   hypothetical protein
Loa Loa (eye worm) LOAG_09838   hypothetical protein
Mus musculus ENSMUSG00000032477   cell division cycle 25A
Mus musculus ENSMUSG00000044201   cell division cycle 25C
Mus musculus ENSMUSG00000027330   cell division cycle 25B
Onchocerca volvulus OVOC6461  
Onchocerca volvulus OVOC6463  
Onchocerca volvulus OVOC6471  
Onchocerca volvulus OVOC6469  
Saccharomyces cerevisiae YMR036C   Mih1p
Schistosoma japonicum Sjp_0028760   ko:K01104 protein-tyrosine phosphatase [EC3.1.3.48], putative
Schistosoma mansoni Smp_152200   m-phase inducer phosphatase(cdc25)
Schmidtea mediterranea mk4.016055.01  
Schmidtea mediterranea mk4.001222.02  
Schmidtea mediterranea mk4.000497.01  
Schmidtea mediterranea mk4.000437.06  
Schmidtea mediterranea mk4.011555.00  
Trichomonas vaginalis TVAG_447150   mitotic inducer phosphatase CDC25, putative
Trichomonas vaginalis TVAG_236640   cdc25b, putative
Trichomonas vaginalis TVAG_266430   mitotic inducer phosphatase CDC25, putative
Trichomonas vaginalis TVAG_456820   m-phase inducer phosphatase, putative
Trichomonas vaginalis TVAG_097620   m-phase inducer phosphatase, putative
Trichomonas vaginalis TVAG_119790   cdc25c, putative
Trichomonas vaginalis TVAG_084370   cdc25b, putative
Trichomonas vaginalis TVAG_374920   mitotic inducer phosphatase CDC25, putative

Essentiality

OVOC6461 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_K06A5.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_K06A5.7 Caenorhabditis elegans sterile wormbase
CELE_F16B4.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_F16B4.8 Caenorhabditis elegans larval lethal wormbase
CELE_F16B4.8 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens cell division cycle 25C Compounds References
Homo sapiens cell division cycle 25A Compounds References
Mus musculus cell division cycle 25B Compounds References
Homo sapiens cell division cycle 25B Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0612 1 1
0.0719 1 1
0.0171 1 1
0.0137 1 0.5
0.0184 0.3779 1
0.0115 0.2831 0.9162
0.161782 1 0.5
0.0126 1 0.5
0.1422 1 1
0.0068 1 0.5
0.126 0.8907 1
0.0537 1 1
0.0674 0.323 1
0.0083 1 0.5
0.0225 1 0.5
0.0419 0.3359 0.6377
0.0213 0.3885 0.4319
0.0658 0.4394 1
0.0137 0.4988 0.4507
0.0068 1 0.5
0.0367 0.2782 1
0.0675 0.9699 1
0.061 0.4 1
0.1433 1 1
0.0675 0.4776 1
0.0205 0.3966 0.3911
0.0137 1 0.5
0.0623 0.3938 1
0.1407 0.865 1
0.1274 1 1
0.0237 0.2562 1
0.0118 0.4096 1
0.1291 0.3431 1
0.0128 0.3846 0.385
0.0468 0.9821 1
0.0137 1 0.5
0.0491 0.2523 0.2536
0.0306 0.3193 0.3353
0.0186 0.6958 1
0.011 0.2835 1
0.0568 0.4033 1
0.0591 0.4157 1
0.0338 0.47 1
0.0284 1 1
0.0235 0.2847 1
0.0062 0.3244 1
0.0231 1 1
0.0926 1 0.5
0.0115 0.2987 0.5502
0.0402 0.4837 1
0.0614 0.3826 1
0.0117 0.3407 0.3866
0.017 0.5653 0.5
0.034 0.471 1
0.1409 1 0.5
0.0137365 0.34706 0.5
0.0068 1 0.5
0.0137 1 0.5
0.0125 0.2919 0.6216
0.0068 1 0.5
0.0263 0.5659 1
0.0601 0.4129 1
0.0298 0.3572 1
0.1274 1 1
0.0358 0.4822 0.5754
0.0118 0.433 0.4123
0.0691 0.9714 1
0.0622 0.3989 1
0.1325 1 1
0.0137 0.632 0.5
0.0127 0.4165 0.6596
0.0124 0.394 1
0.0166 0.6121 0.0543
0.0197 1 0.5
0.0419 0.3359 0.6377
0.0613 0.2877 1
0.0116 1 0.5
0.0619 0.4467 1
0.012 0.3242 0.5489
0.0199 0.3899 1
0.0130368 1 0.5
0.0124 0.3671 0.3671
0.1325 1 1
0.0116 0.3402 0.3861
0.0765 0.5146 1
0.0114 0.3543 0.3404
0.0172 1 1
0.0199 0.3899 1
0.0228 0.3136 0.7286
0.0119 0.4268 0.4255
0.042 0.4291 1
0.0229 0.3155 1
0.0445 0.3173 1
0.0068 0.3605 0.5
0.0588 0.4085 1
0.0167 1 0.5
0.0344 0.2554 1
0.0122 0.6499 1
0.0135677 0.78853 1
0.0173 0.7401 1
0.0068 1 0.5
0.0083 1 0.5
0.0165 0.4047 1
0.0064 0.6894 0
0.026 0.3244 1
0.0674 0.323 1
0.0164 1 1
0.0122 0.9539 0.5
0.0347 0.3107 1
0.0068 1 0.5
0.1407 0.865 1
0.0137 0.3014 0.4485
0.0583 0.3167 1
0.0658 1 0.5
0.0252 0.5413 0.4812
0.0058 0.6913 0.6913
0.1243 0.7835 1
0.0468 0.9821 1
0.0566 0.7034 1
0.0211 0.2562 1
0.0137 1 0.5
0.0171 1 0.5
0.0137 1 0.5
0.0592 0.2721 1
0.0212 1 0.5
0.062 0.4062 1
0.0249 1 0.5
0.0122 0.3268 0.6005
0.0189 1 1
0.022 0.4714 0.4714
0.0336 0.4419 0.7377
0.0605 0.4126 1
0.023 0.2707 0.2707
0.0902 0.2532 0.506
0.012 0.3242 0.5489
0.0286 0.6743 1
0.0124 0.3798 0.3856
0.017 0.3369 0.9263
0.0113 0.4423 0.5
0.0638 0.4268 1
0.013408 1 0.5
0.0111 0.9921 0.5
0.0519 1 0.5
0.1412 1 1
0.0186 0.6133 1
0.0676 1 1
0.1464 1 0.5
0.0344 1 1
0.0112 1 0.5
0.1407 0.865 1
0.0491 0.2523 0.2536
0.012 0.341 0.3861
0.0187 0.6062 0.6023
0.017 0.3369 0.9263
0.0205 0.2728 0.5
0.0409 1 1
0.1355 0.4384 1
0.0131073 0.808733 0.5
0.0236 0.2799 0.5
0.026 0.3982 0
0.0113 0.3235 0.3159
0.0205 1 1
0.0122 0.6707 0.5
0.0115 0.3926 0.533
0.0727 1 1
0.0331 0.4088 1
0.0595 0.275 1
0.1422 1 1
0.012 1 0.5
0.0091 0.2567 0.257
0.0302 0.8506 1
0.0165 0.5242 0.659
0.0572 0.2625 1
0.0656 1 1
0.0992 1 0.5
0.0064 0.6894 0
0.0223 0.3064 1
0.0255 0.5537 0.5067
0.00651679 0.637622 0.5
0.0644 0.4403 1
0.0112 0.4422 0.5
0.042 0.3606 1
0.0111 0.65 0.5
0.011 0.3356 1
0.057 0.3831 1
0.0109 1 0.5
0.0352 0.4974 1
0.064 0.7533 1
0.0113 0.3235 0.3159
0.1121 1 0.5
0.0187 0.6062 0.6023
0.0239 0.2877 1
0.0306 0.3193 0.3353
0.0297 0.2955 0.3915
0.0137 0.3259 1
0.0137 1 0.5
0.0648 1 1
0.0113 0.9912 0.5
0.0121 0.3055 1
0.0137 1 0.5
0.0118 0.433 0.4123
0.0154162 1 0.5
0.064 0.7533 1
0.0242 1 0.5
0.0558 0.3731 1
0.0306 0.3193 0.3353
0.0578 0.8312 1
0.0914 1 1
0.0635 1 1
0.0137 1 0.5
0.1399 1 0.5
0.0656 1 1
0.0173 0.8258 1
0.0603 0.6997 1
0.0555 0.2602 1
0.0059 0.4655 1
0.0068 0.2567 0
0.021 0.3271 0.4083
0.0614 0.3826 1
0.0176 1 0.5
0.0137 0.714 1
0.0505 1 1
0.0232 1 1
0.0301 1 1
0.1355 0.4384 1
0.0059 0.3478 1
0.0737 1 1
0.0115 0.4757 0.4736
0.0294 0.3355 1
0.0658 0.4394 1
0.0515 0.3544 1
0.1291 0.3431 1
0.0267 1 1
0.1397 0.2823 1
0.0187 0.6062 0.6023
0.0137 0.4989 1
0.0116 0.3189 0
0.0166 0.4268 0.6782
0.0123 0.3127 1
0.0047 1 0.5
0.0929 1 0.5
0.0122 0.3238 0.574
0.0182 1 1
0.0591 1 0.5
0.057 0.2565 1
0.0118 1 1
0.0205 1 0.5
0.0583 0.3167 1
0.0717 1 1
0.0657 0.4826 1
0.0119 0.4268 0.4255
0.0165 0.5242 0.659
0.0178 0.9635 0.5
0.0676 1 1
0.0729 0.5402 1
0.0623 0.3938 1
0.0111 0.3098 0.3879
0.0126 0.3036 0.4698
0.0173 0.3079 1
0.057 0.3831 1
0.059 0.4127 1
0.0205 0.2728 1
0.0122 0.8446 1
0.0491 0.2523 0.2536
0.0658 1 0.5
0.0058 0.2607 0
0.0193 1 0.5
0.0468 0.9821 1
0.0458 0.4704 0.6227
0.0513 0.3381 1
0.0591 0.3849 1
0.0563 0.6808 1
0.063 0.2588 0.5
0.1014 1 1
0.0515 0.3461 1
0.0644 0.4403 1
0.0174 0.7566 0.5
0.0072 1 0.5
0.0332 1 1
0.0112 1 0.5
0.007 1 0.5
0.0719 1 1
0.1464 1 0.5
0.0606 0.394 1
0.0414 1 1
0.0199 0.3899 1
0.0168 0.3563 0.6201
0.0068 1 0.5
0.011 0.4336 1
0.0419 0.3359 0.6377
0.0656 1 1
0.023 0.2707 0.2707
0.0068 1 1
0.011 0.3359 1
0.0419 0.3359 0.6377
0.0187 0.6062 0.6023
0.147 1 1
0.0005 0.3625 0.3625
0.0137 0.5381 1
0.0585 0.3923 1
0.0205 1 0.5
0.0121 1 1
0.0164 0.661 1
0.0059 1 1
0.0487 0.357 1
0.0797 0.484 1
0.0111 0.2866 1
0.0137 1 0.5
0.0111 1 0.5
0.0232 0.5315 0.5199
0.0297 0.2955 0.3915
0.0902 0.2532 0.506
0.0334 0.4883 1
0.0137 0.7182 0.5
0.0517 0.3543 1
0.0596 0.401 1
0.0056 0.2771 1
0.0588 0.3811 1
0.0173 0.5723 0.7246
0.013 0.2837 1
0.0184 0.3779 1
0.0244 0.2879 0.5407
0.0853 0.9314 1
0.1448 0.9324 1
0.0758 1 0.5
0.0068 1 0.5
0.1414 1 0.5
0.0113 0.7204 1
0.011 1 0.5
0.1327 1 0.5
0.0342 0.4675 1
0.0221 0.3146 0.4991
0.0111 0.2866 1
0.0568 0.3739 1
0.0674 0.323 1
0.0291 0.7377 1
0.0409 1 1
0.0287 1 1
0.1114 1 1
0.0119 0.4268 0.4255
0.0175 0.6384 0.6327
0.1375 1 1
0.0295 1 0.5
0.0068 1 0.5
0.0263 0.5659 1
0.1407 0.865 1
0.0124 0.3836 1
0.0684 1 0.5
0.0109 1 0.5
0.0171 1 1
0.0057 0.2648 1
0.0712 1 0.5
0.0576 0.2752 0.6012
0.0211 0.2562 1
0.0677 0.8048 1
0.0176 0.9544 1
0.0091 0.2567 0.257
0.0419 0.3359 0.6377
0.0633 0.4212 1
0.0573 0.4055 1
0.0226 0.761 0.7597
0.0118 0.4154 0.4123
0.0057 0.399 0.5
0.0124 0.3915 0.3856
0.0558 1 0.5
0.0124 0.394 1
0.0128 0.2643 0.4412
0.012951 1 0.5
0.0128 0.8902 1
0.017 1 0.5
0.1418 0.511 1
0.0339 1 1
0.0576 0.2752 0.6012
0.0677 0.8048 1
0.0576 0.2752 0.6012
0.0571 0.3933 1
0.0118 0.4465 1
0.0134 0.4476 0.6907
0.0674 0.323 1
0.0452 0.3692 1
0.0128 0.2643 0.4412
0.026 0.3982 0
0.019 0.2833 1
0.0677 0.8048 1
0.0893553 1 0.5
0.1046 1 1
0.1046 1 1
0.0123 0.3937 0.6279
0.0117 0.2913 0.5698
0.011 0.274 0.4713
0.0224 1 1
0.0115 0.2831 0.9162
0.0059 1 0.5
0.0555 0.2602 1
0.0579 0.4049 1
0.0117 1 1
0.0114 1 0.5
0.0263 0.5784 0.5757
0.0111 0.65 0.5
0.0306 0.3193 0.3353
0.0245 0.5354 0.4509
0.0066 0.4329 0.7316
0.0302 0.8506 1
0.1424 1 0.5
0.0489 1 1
0.0943 1 1
0.0167 1 0.5
0.0137 1 0.5
0.0588 0.4068 1
0.0068 0.666 0.2451
0.0174 0.451 0.9375
0.0179 1 0.5
0.0125 0.2919 0.6216
0.0605 0.3964 1
0.0434 0.3957 0.9564
0.0588 0.3811 1
0.0068 1 0.5
0.1397 0.2823 1
0.0221 0.3146 0.4991
0.0055 0.3982 0.5
0.0231 1 1
0.0572 0.333 0.7751
0.0318 0.2861 0
0.0068 1 0.5
0.018 0.5749 1
0.0205 0.2728 0.5
0.0108 0.2637 1
0.0165 1 1
0.012 0.4125 0.4125
0.0199 0.3899 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier OVOC6461 (Onchocerca volvulus),
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