Detailed view for OVOC5304

Basic information

TDR Targets ID: 989608
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 10.1906 | Length (AA): 485 | MW (Da): 55620 | Paralog Number: 25

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03564  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
112 153 5mqp (A) 126 167 36.00 0.035 0.03 0.405851 2.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127018)

Species Accession Gene Product
Brugia malayi Bm1_19715   Zinc knuckle family protein
Brugia malayi Bm1_21295   hypothetical protein
Brugia malayi Bm1_02665   gag protein
Brugia malayi Bm1_40110   reverse transcriptase
Brugia malayi Bm1_00310   hypothetical protein
Brugia malayi Bm1_28545   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_19160   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_50020   Integrase core domain containing protein
Brugia malayi Bm1_47680   hypothetical protein
Brugia malayi Bm1_29300   Integrase core domain containing protein
Brugia malayi Bm1_47690   Integrase core domain containing protein
Brugia malayi Bm1_05235   hypothetical protein
Brugia malayi Bm1_18655   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_16885   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_54135   Integrase core domain containing protein
Brugia malayi Bm1_10585   Integrase core domain containing protein
Brugia malayi Bm1_12415   Zinc knuckle family protein
Brugia malayi Bm1_21465   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_07455   reverse transcriptase
Brugia malayi Bm1_23700   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_38075   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_04025   gag protein
Brugia malayi Bm1_17815   hypothetical protein
Brugia malayi Bm1_06135   Zinc knuckle family protein
Brugia malayi Bm1_50025   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_38620   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_53430   hypothetical protein
Brugia malayi Bm1_00285   hypothetical protein
Brugia malayi Bm1_04290   Zinc knuckle family protein
Brugia malayi Bm1_10715   hypothetical protein
Brugia malayi Bm1_28220   Integrase core domain containing protein
Brugia malayi Bm1_05875   hypothetical protein
Brugia malayi Bm1_05365   hypothetical protein
Brugia malayi Bm1_04580   Integrase core domain containing protein
Brugia malayi Bm1_19710   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_05585   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_11635   gag protein
Brugia malayi Bm1_21710   reverse transcriptase
Brugia malayi Bm1_36445   hypothetical protein
Brugia malayi Bm1_14460   Integrase core domain containing protein
Brugia malayi Bm1_21320   Integrase core domain containing protein
Brugia malayi Bm1_07240   Zinc knuckle family protein
Brugia malayi Bm1_14760   Integrase core domain containing protein
Brugia malayi Bm1_03375   gag protein
Brugia malayi Bm1_32840   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_20960   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_36875   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_01240   Zinc knuckle family protein
Brugia malayi Bm1_26895   hypothetical protein
Brugia malayi Bm1_48055   Integrase core domain containing protein
Brugia malayi Bm1_04550   hypothetical protein
Brugia malayi Bm1_09440   Zinc knuckle family protein
Brugia malayi Bm1_26910   hypothetical protein
Brugia malayi Bm1_37380   Integrase core domain containing protein
Brugia malayi Bm1_23830   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_23290   Zinc knuckle family protein
Brugia malayi Bm1_23295   hypothetical protein
Brugia malayi Bm1_39865   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_24455   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_39410   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_05245   hypothetical protein
Brugia malayi Bm1_53695   hypothetical protein
Brugia malayi Bm1_11295   gag protein
Brugia malayi Bm1_57480   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_00125   Zinc knuckle family protein
Brugia malayi Bm1_24270   hypothetical protein
Brugia malayi Bm1_26010   hypothetical protein
Brugia malayi Bm1_07330   Zinc knuckle family protein
Brugia malayi Bm1_47105   hypothetical protein
Brugia malayi Bm1_29180   Pao retrotransposon peptidase family protein
Brugia malayi Bm1_05240   hypothetical protein
Brugia malayi Bm1_39415   Integrase core domain containing protein
Brugia malayi Bm1_12420   hypothetical protein
Brugia malayi Bm1_11205   Zinc knuckle family protein
Brugia malayi Bm1_28540   hypothetical protein
Brugia malayi Bm1_30890   hypothetical protein
Brugia malayi Bm1_16840   Zinc knuckle family protein
Brugia malayi Bm1_06870   Pao retrotransposon peptidase family protein
Caenorhabditis elegans CELE_Y20F4.8   Protein Y20F4.8
Caenorhabditis elegans CELE_T16H12.2   Protein T16H12.2
Loa Loa (eye worm) LOAG_14234   hypothetical protein
Loa Loa (eye worm) LOAG_13246   hypothetical protein
Loa Loa (eye worm) LOAG_14705   hypothetical protein
Loa Loa (eye worm) LOAG_07541   hypothetical protein
Loa Loa (eye worm) LOAG_14280   hypothetical protein
Loa Loa (eye worm) LOAG_15857   hypothetical protein
Loa Loa (eye worm) LOAG_01728   hypothetical protein
Loa Loa (eye worm) LOAG_16185   hypothetical protein
Loa Loa (eye worm) LOAG_12337   hypothetical protein
Loa Loa (eye worm) LOAG_06961   hypothetical protein
Loa Loa (eye worm) LOAG_10129   hypothetical protein
Loa Loa (eye worm) LOAG_14215   hypothetical protein
Loa Loa (eye worm) LOAG_15482   hypothetical protein
Loa Loa (eye worm) LOAG_13719   hypothetical protein
Loa Loa (eye worm) LOAG_06963   hypothetical protein
Loa Loa (eye worm) LOAG_10289   hypothetical protein
Loa Loa (eye worm) LOAG_13748   pao retrotransposon peptidase
Loa Loa (eye worm) LOAG_15307   hypothetical protein
Loa Loa (eye worm) LOAG_16110   hypothetical protein
Loa Loa (eye worm) LOAG_02888   hypothetical protein
Loa Loa (eye worm) LOAG_12013   hypothetical protein
Loa Loa (eye worm) LOAG_11807   zinc knuckle family protein
Onchocerca volvulus OVOC10123  
Onchocerca volvulus OVOC12925  
Onchocerca volvulus OVOC10433  
Onchocerca volvulus OVOC12724  
Onchocerca volvulus OVOC5894  
Onchocerca volvulus OVOC4738  
Onchocerca volvulus OVOC12890  
Onchocerca volvulus OVOC12618  
Onchocerca volvulus OVOC12098  
Onchocerca volvulus OVOC3189  
Onchocerca volvulus OVOC10840  
Onchocerca volvulus OVOC11563  
Onchocerca volvulus OVOC12546  
Onchocerca volvulus OVOC12920  
Onchocerca volvulus OVOC12344  
Onchocerca volvulus OVOC12723  
Onchocerca volvulus OVOC12753  
Onchocerca volvulus OVOC1867  
Onchocerca volvulus OVOC486  
Onchocerca volvulus OVOC8743  
Onchocerca volvulus OVOC10900  
Onchocerca volvulus OVOC5304  
Onchocerca volvulus OVOC10839  
Onchocerca volvulus OVOC187  
Onchocerca volvulus OVOC12617  
Onchocerca volvulus OVOC12416  
Schistosoma japonicum Sjp_0072920   IPR001878,Zinc finger, CCHC-type;IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0073190   IPR001878,Zinc finger, CCHC-type;IPR009007,Peptidase aspartic, catalytic,domain-containing
Schistosoma japonicum Sjp_0130320   Conserved hypothetical protein
Schistosoma japonicum Sjp_0122440   IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0087940   IPR001878,Zinc finger, CCHC-type;IPR009007,Peptidase aspartic, catalytic,domain-containing
Schistosoma japonicum Sjp_0113520   IPR008042,Retrotransposon, Pao;IPR009007,Peptidase aspartic, catalytic,domain-containing
Schistosoma japonicum Sjp_0114410   IPR008042,Retrotransposon, Pao;IPR009007,Peptidase aspartic, catalytic,domain-containing
Schistosoma japonicum Sjp_0019220   Conserved hypothetical protein
Schistosoma japonicum Sjp_0122700   IPR008042,Retrotransposon, Pao;IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing
Schistosoma japonicum Sjp_0008340   IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0027030   GRB2-related adapter protein, putative
Schistosoma japonicum Sjp_0126410   Conserved hypothetical protein
Schistosoma japonicum Sjp_0007830   IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0110320   IPR001878,Zinc finger, CCHC-type;IPR009007,Peptidase aspartic, catalytic,domain-containing
Schistosoma japonicum Sjp_0017880   IPR009007,Peptidase aspartic, catalytic,domain-containing
Schistosoma japonicum Sjp_0097050   IPR008042,Retrotransposon, Pao;IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing
Schistosoma japonicum Sjp_0034590   IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0092420   IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0116500   IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0017090   IPR009007,Peptidase aspartic, catalytic,domain-containing
Schistosoma japonicum Sjp_0038940   IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0036330   IPR001584,Integrase, catalytic region;IPR008042,Retrotransposon, Pao;IPR001878,Zinc finger, CCHC-type;IPR012337,Polynucleotidyl
Schistosoma japonicum Sjp_0079360   IPR009007,Peptidase aspartic, catalytic,domain-containing
Schistosoma japonicum Sjp_0009760   IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0014460   IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0095910   Conserved hypothetical protein
Schistosoma japonicum Sjp_0109780   Conserved hypothetical protein
Schistosoma japonicum Sjp_0109760   IPR009007,Peptidase aspartic, catalytic,domain-containing
Schistosoma japonicum Sjp_0116570   IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0116600   Conserved hypothetical protein
Schistosoma japonicum Sjp_0078040   IPR001584,Integrase, catalytic region;IPR008042,Retrotransposon, Pao;IPR006162,Phosphopantetheine attachment site;IPR009007,Pept
Schistosoma japonicum Sjp_0077430   IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0103010   Conserved hypothetical protein
Schistosoma japonicum Sjp_0118920   IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0125840   IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0036140   IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0025110   hypothetical protein
Schistosoma japonicum Sjp_0104820   Rab6-interacting protein 1, putative
Schistosoma japonicum Sjp_0036310   IPR008042,Retrotransposon, Pao;IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing
Schistosoma japonicum Sjp_0119990   Conserved hypothetical protein
Schistosoma japonicum Sjp_0118620   IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0089240   IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0219700   IPR012337,Polynucleotidyl transferase, Ribonuclease H fold;IPR001584,Integrase, catalytic core,domain-containing
Schistosoma japonicum Sjp_0017070   Conserved hypothetical protein
Schistosoma japonicum Sjp_0049130   IPR001878,Zinc finger, CCHC-type;IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0103510   Conserved hypothetical protein
Schistosoma japonicum Sjp_0058460   IPR009007,Peptidase aspartic, catalytic,domain-containing
Schistosoma japonicum Sjp_0022760   IPR009007,Peptidase aspartic, catalytic,domain-containing
Schistosoma japonicum Sjp_0008290   IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0133680   IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0037590   IPR008042,Retrotransposon, Pao,domain-containing
Schistosoma japonicum Sjp_0131590   IPR008042,Retrotransposon, Pao;IPR009007,Peptidase aspartic, catalytic,domain-containing
Schistosoma japonicum Sjp_0212660   IPR008042,Retrotransposon, Pao;IPR011009,Protein kinase-like,domain-containing
Schistosoma japonicum Sjp_0129350   Conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Muscarinic acetylcholine receptor 466 aa 24.6% 472 aa Compounds References
Rattus norvegicus Alpha-2a adrenergic receptor 450 aa 25.1% 467 aa Compounds References
Rattus norvegicus Alpha-2b adrenergic receptor 453 aa 26.1% 456 aa Compounds References
Sus scrofa Alpha-2a adrenergic receptor 450 aa 26.9% 464 aa Compounds References
Chlorocebus aethiops Dopamine D2 receptor 443 aa 27.2% 463 aa Compounds References
Bos taurus Cerebral cortex alpha adrenergic receptor 452 aa 27.4% 471 aa Compounds References
Rattus norvegicus Muscarinic acetylcholine receptor M2 466 aa 24.6% 472 aa Compounds References
Rattus norvegicus Adrenergic receptor alpha-2 450 aa 25.1% 467 aa Compounds References
Chlorocebus aethiops Dopamine D3 receptor 400 aa 26.3% 457 aa Compounds References
Macaca mulatta Gonadotropin-releasing hormone receptor 59 aa 25.0% 52 aa Compounds References
Rattus norvegicus C-C chemokine receptor type 2 373 aa 22.4% 317 aa Compounds References
Bos taurus Dopamine D2 receptor 444 aa 27.4% 464 aa Compounds References
Cavia porcellus Mu opioid receptor 98 aa 28.1% 96 aa Compounds References
Cavia porcellus Muscarinic receptor 2 466 aa 25.4% 472 aa Compounds References
Rattus norvegicus Dopamine D3 receptor 446 aa 26.0% 462 aa Compounds References
Sus scrofa Muscarinic acetylcholine receptor M2 466 aa 24.8% 472 aa Compounds References
Chilo suppressalis TyR1 478 aa 32.2% 447 aa Compounds References
Bos taurus Alpha-2a adrenergic receptor 452 aa 27.4% 471 aa Compounds References
Cavia porcellus Muscarinic receptor 4 477 aa 24.7% 474 aa Compounds References
Oryctolagus cuniculus Uncharacterized protein 460 aa 24.4% 467 aa Compounds References
Rattus norvegicus Muscarinic acetylcholine receptor M4 478 aa 24.5% 473 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC5304 (Onchocerca volvulus),
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