Detailed view for OVOC3014

Basic information

TDR Targets ID: 989895
Onchocerca volvulus, 26S proteasome non-ATPase regulatory subunit 1 homolog
Source Database / ID:  Wormbase Parasite  

pI: 9.6198 | Length (AA): 400 | MW (Da): 46085 | Paralog Number: 8169

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 6

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
18 966 4ady (A) 5 914 35.00 0 1 1.09076 0.08
181 352 5a6d (A) 15 186 31.00 0.31 0.05 0.0848212 1.69
622 731 5mfi (A) 50 171 30.00 0.98 0.99 0.450148 -0.79
651 807 3ltj (A) 39 184 27.00 0 1 0.40981 -0.35
739 1069 4ady (B) 609 925 41.00 0.0011 1 0.359259 0.92

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Gorilla gorilla Serotonin 1b (5-HT1b) receptor 390 aa 25.1% 387 aa Compounds References
Rattus norvegicus Serotonin 1f (5-HT1f) receptor 366 aa 26.2% 405 aa Compounds References
Sus scrofa Serotonin 1d (5-HT1d) receptor 291 aa 25.9% 336 aa Compounds References
Rattus norvegicus Serotonin 1B/1D receptor 374 aa 25.8% 399 aa Compounds References
Rattus norvegicus Serotonin 1 (5-HT1) receptor 366 aa 26.2% 405 aa Compounds References
Cavia porcellus Histamine H4 receptor 389 aa 23.4% 367 aa Compounds References
Rattus norvegicus Serotonin 1d (5-HT1d) receptor 374 aa 25.8% 399 aa Compounds References
Rattus norvegicus Adenosine receptor 332 aa 23.6% 276 aa Compounds References
Cricetulus griseus 5-hydroxytryptamine receptor 1B 386 aa 25.1% 366 aa Compounds References
Cavia porcellus Mu opioid receptor 98 aa 28.8% 80 aa Compounds References
Rattus norvegicus Histamine H4 receptor 391 aa 24.5% 331 aa Compounds References
Rattus norvegicus Dopamine D4 receptor 387 aa 27.0% 371 aa Compounds References
Rattus norvegicus Adenosine A2b receptor 332 aa 23.6% 276 aa Compounds References
Rattus norvegicus Serotonin 5b (5-HT5b) receptor 370 aa 25.3% 344 aa Compounds References
Rattus norvegicus Serotonin 1b (5-HT1b) receptor 386 aa 26.1% 371 aa Compounds References
Rattus norvegicus Serotonin (5-HT) receptor 386 aa 26.1% 371 aa Compounds References
Cavia porcellus Serotonin 1d (5-HT1d) receptor 376 aa 26.3% 358 aa Compounds References
Bos taurus 5-hydroxytryptamine 1D receptor 119 aa 38.6% 101 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier OVOC3014 (Onchocerca volvulus), 26S proteasome non-ATPase regulatory subunit 1 homolog
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