Detailed view for OVOC12028

Basic information

TDR Targets ID: 990981
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 10.6526 | Length (AA): 369 | MW (Da): 43279 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01062  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 366 4rdq (A) 2 363 37.00 0 1 1.403 0.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130510)

Species Accession Gene Product
Brugia malayi Bm1_50810   Bestrophin family protein
Brugia malayi Bm1_46200   Bestrophin family protein
Caenorhabditis elegans CELE_C01B12.3   Protein BEST-3
Caenorhabditis elegans CELE_C01B12.5   Protein BEST-4
Caenorhabditis elegans CELE_ZC518.1   Protein BEST-22, isoform B
Caenorhabditis elegans CELE_ZK688.2   Protein BEST-24
Drosophila melanogaster Dmel_CG6264   Bestrophin 1
Echinococcus granulosus EgrG_000491600   bestrophin 3
Echinococcus granulosus EgrG_000672700   bestrophin 2
Echinococcus granulosus EgrG_000474000   bestrophin
Echinococcus granulosus EgrG_000492000   bestrophin 3
Echinococcus multilocularis EmuJ_000672700   bestrophin 2
Echinococcus multilocularis EmuJ_000474000   bestrophin
Echinococcus multilocularis EmuJ_000491600   bestrophin 3
Echinococcus multilocularis EmuJ_000492000   bestrophin 3
Homo sapiens ENSG00000039987   bestrophin 2
Homo sapiens ENSG00000127325   bestrophin 3
Loa Loa (eye worm) LOAG_13750   hypothetical protein
Loa Loa (eye worm) LOAG_16137   hypothetical protein
Loa Loa (eye worm) LOAG_12640   hypothetical protein
Loa Loa (eye worm) LOAG_15332   hypothetical protein
Mus musculus ENSMUSG00000052819   bestrophin 2
Mus musculus ENSMUSG00000020169   bestrophin 3
Onchocerca volvulus OVOC12028  
Onchocerca volvulus OVOC2318  
Onchocerca volvulus OVOC8572  
Schistosoma japonicum Sjp_0206850   Bestrophin-3, putative
Schistosoma mansoni Smp_131460   bestrophin-related
Schmidtea mediterranea mk4.000018.03   Bestrophin-related
Schmidtea mediterranea mk4.013911.01   Bestrophin-related
Schmidtea mediterranea mk4.000314.01   Bestrophin-related
Schmidtea mediterranea mk4.000144.13  
Schmidtea mediterranea mk4.000144.15  
Schmidtea mediterranea mk4.006034.03  
Schmidtea mediterranea mk4.007913.02  
Schmidtea mediterranea mk4.002738.02  
Schmidtea mediterranea mk4.005784.01  
Schmidtea mediterranea mk4.019274.01  
Schmidtea mediterranea mk4.000381.02  
Schmidtea mediterranea mk4.000144.14  
Schmidtea mediterranea mk4.001752.05   Bestrophin-related

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Cavia porcellus Histamine H2 receptor 359 aa 22.2% 311 aa Compounds References
Ovis aries Ghrelin receptor 366 aa 20.7% 358 aa Compounds References
Gallus gallus Melatonin receptor 346 aa 22.1% 308 aa Compounds References
Rattus norvegicus Adenosine receptor 332 aa 20.5% 273 aa Compounds References
Macaca mulatta B1 bradykinin receptor 352 aa 20.8% 380 aa Compounds References
Rattus norvegicus Ghrelin receptor 364 aa 21.1% 341 aa Compounds References
Rattus norvegicus Adenosine A2b receptor 332 aa 20.5% 273 aa Compounds References
Oryctolagus cuniculus Growth hormone secretagogue receptor type 1 366 aa 22.4% 340 aa Compounds References
Cavia porcellus Platelet activating factor receptor 342 aa 21.7% 327 aa Compounds References
Macaca fascicularis B1 bradykinin receptor 352 aa 20.8% 380 aa Compounds References
Sus scrofa Ghrelin receptor 366 aa 22.4% 362 aa Compounds References
Rattus norvegicus Platelet activating factor receptor 341 aa 21.0% 324 aa Compounds References
Oryctolagus cuniculus Adenosine A3 receptor 319 aa 19.9% 326 aa Compounds References
Canis lupus familiaris Bradykinin B1 receptor 350 aa 22.3% 367 aa Compounds References
Bos taurus Adenosine receptor A3 317 aa 21.9% 302 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier OVOC12028 (Onchocerca volvulus),
Title for this comment
Comment