Detailed view for OVOC3743

Basic information

TDR Targets ID: 991197
Onchocerca volvulus,

Source Database / ID:  Wormbase Parasite  

pI: 8.1034 | Length (AA): 385 | MW (Da): 44170 | Paralog Number: 8169

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 5

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Platelet activating factor receptor 341 aa 25.2% 321 aa Compounds References
Oryctolagus cuniculus Bradykinin B2 receptor 367 aa 21.7% 304 aa Compounds References
Mesocricetus auratus Neurokinin 2 receptor 384 aa 27.1% 325 aa Compounds References
Human cytomegalovirus G protein-coupled receptor 354 aa 21.1% 299 aa Compounds References
Rattus norvegicus Type-1A angiotensin II receptor 359 aa 23.8% 294 aa Compounds References
Cavia porcellus Histamine H2 receptor 359 aa 26.0% 319 aa Compounds References
Canis familiaris Chemokine (C-C motif) receptor 1 354 aa 22.8% 302 aa Compounds References
Gallus gallus Melatonin receptor 346 aa 23.0% 300 aa Compounds References
Rattus norvegicus Adenosine receptor 332 aa 24.5% 302 aa Compounds References
Rattus norvegicus Purinergic receptor P2Y1 373 aa 22.4% 304 aa Compounds References
Macaca fascicularis C-C chemokine receptor type 5 352 aa 24.4% 299 aa Compounds References
Rattus norvegicus C-X-C chemokine receptor type 4 349 aa 23.9% 310 aa Compounds References
Rattus norvegicus Galanin receptor 1 346 aa 26.0% 327 aa Compounds References
Rattus norvegicus Free fatty acid receptor 4 361 aa 24.6% 329 aa Compounds References
Rattus norvegicus Type-1B angiotensin II receptor 359 aa 24.7% 292 aa Compounds References
Rattus norvegicus Angiotensin II receptor (AT-1) type-1 359 aa 24.7% 292 aa Compounds References
Macaca fascicularis C-C chemokine receptor type 3 355 aa 22.7% 309 aa Compounds References
Cavia porcellus Mu opioid receptor 98 aa 35.0% 80 aa Compounds References
Rattus norvegicus Kappa opioid receptor 380 aa 24.4% 344 aa Compounds References
Macaca fascicularis Melanin-concentrating hormone receptor 1 249 aa 23.3% 232 aa Compounds References
Macaca mulatta CXC chemokine receptor 3 368 aa 25.1% 299 aa Compounds References
Sus scrofa Serotonin 1d (5-HT1d) receptor 291 aa 21.5% 297 aa Compounds References
Rattus norvegicus Serotonin 1B/1D receptor 374 aa 21.7% 332 aa Compounds References
Macaca mulatta Gonadotropin-releasing hormone receptor 59 aa 21.9% 64 aa Compounds References
Macaca mulatta Trace amine-associated receptor 1 338 aa 22.0% 323 aa Compounds References
Rattus norvegicus Angiotensin II type 2 (AT-2) receptor 363 aa 22.5% 306 aa Compounds References
Canis lupus familiaris Bradykinin B1 receptor 350 aa 21.7% 290 aa Compounds References
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) Human herpesvirus 5 chemokine receptor 354 aa 20.7% 299 aa Compounds References
Cavia porcellus Type-1 angiotensin II receptor 359 aa 25.3% 293 aa Compounds References
Rattus norvegicus Serotonin 5b (5-HT5b) receptor 370 aa 17.8% 297 aa Compounds References
Rattus norvegicus C-C chemokine receptor type 3 359 aa 25.9% 294 aa Compounds References
Carassius auratus Dopamine D1 receptor 363 aa 24.6% 313 aa Compounds References
Rattus norvegicus Neuropeptide Y receptor type 1 382 aa 27.7% 321 aa Compounds References
Rattus norvegicus Serotonin 1d (5-HT1d) receptor 374 aa 21.7% 332 aa Compounds References
Macaca mulatta C-X-C chemokine receptor type 4 352 aa 25.2% 298 aa Compounds References
Oryctolagus cuniculus C-X-C chemokine receptor type 2 358 aa 26.6% 290 aa Compounds References
Rattus norvegicus Angiotensin II receptor 359 aa 23.8% 294 aa Compounds References
Rattus norvegicus Serotonin 5a (5-HT5a) receptor 357 aa 15.7% 299 aa Compounds References
Rattus norvegicus Trace amine-associated receptor 7b 358 aa 26.5% 309 aa Compounds References
Oryctolagus cuniculus Angiotensin II type 1a (AT-1a) receptor 359 aa 25.8% 306 aa Compounds References
Rattus norvegicus Adenosine A2b receptor 332 aa 24.5% 302 aa Compounds References
Macaca mulatta B1 bradykinin receptor 352 aa 23.8% 294 aa Compounds References
Macaca fascicularis B1 bradykinin receptor 352 aa 23.8% 294 aa Compounds References
Rattus norvegicus Histamine H2 receptor 358 aa 25.1% 327 aa Compounds References
Bos taurus Rhodopsin 348 aa 21.9% 301 aa Compounds References
Rattus norvegicus Trace amine-associated receptor 1 332 aa 22.3% 319 aa Compounds References
Rattus norvegicus Cannabinoid CB2 receptor 360 aa 21.9% 297 aa Compounds References
Rattus norvegicus Thyrotropin-releasing hormone receptor 2 352 aa 24.1% 290 aa Compounds References
Rattus norvegicus Gonadotropin-releasing hormone receptor 327 aa 19.0% 336 aa Compounds References
Macaca mulatta C-C chemokine receptor type 5 352 aa 24.4% 299 aa Compounds References
Rattus norvegicus Serotonin 1f (5-HT1f) receptor 366 aa 21.4% 360 aa Compounds References
Sus scrofa Type-1 angiotensin II receptor 359 aa 26.2% 298 aa Compounds References
Bos taurus Angiotensin II type 1a (AT-1a) receptor 359 aa 25.7% 292 aa Compounds References
Macaca mulatta C-C chemokine receptor type 3 355 aa 23.2% 311 aa Compounds References
Rattus norvegicus Succinate receptor 1 317 aa 21.6% 296 aa Compounds References
Cavia porcellus Serotonin 1d (5-HT1d) receptor 376 aa 22.5% 333 aa Compounds References
Bos taurus Adenosine receptor A3 317 aa 25.3% 320 aa Compounds References
Cavia porcellus Platelet activating factor receptor 342 aa 24.7% 320 aa Compounds References
Rattus norvegicus Serotonin 1 (5-HT1) receptor 366 aa 21.4% 360 aa Compounds References
Gallus gallus Melatonin receptor 1B 289 aa 22.1% 271 aa Compounds References
Rattus norvegicus Gastrin releasing peptide receptor 384 aa 24.4% 324 aa Compounds References
Oryctolagus cuniculus Chemokine receptor 351 aa 20.9% 297 aa Compounds References
Rattus norvegicus C-C chemokine receptor type 1 355 aa 24.2% 330 aa Compounds References

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC3743 (Onchocerca volvulus),
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