Detailed view for OVOC9240

Basic information

TDR Targets ID: 992338
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 7.7072 | Length (AA): 1254 | MW (Da): 137543 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00041  

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 16 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
23 110 1x5y (A) 5 83 20.00 0.048 0.25 0.111505 -0.09
27 112 2yuw (A) 8 84 23.00 0.024 0.95 0.230082 -0.28
27 118 4wtw (A) 1458 1538 20.00 0.23 0.78 0.19835 -0.62
142 213 6hnf (A) 183 255 38.00 0.55 0.94 0.497622 -0.61
147 213 5j7k (E) 7 72 42.00 0.11 0.98 0.481565 -0.42
443 534 4n68 (A) 879 970 33.00 0.05 1 0.56885 -1.72
443 529 1ten (A) 806 888 27.00 0 0.9 0.323793 -1.43
709 924 4waf (B) 354 588 21.00 0.032 0.96 0.308066 -0.69
833 871 2jee (A) 30 70 44.00 0.91 0.08 0.632645 -2.39
845 923 6azy (A) 409 487 29.00 0.65 0.15 0.567102 -2.78
1407 1752 4yh7 (A) 271 611 27.00 0.000000000007 1 0.16255 1.18
1554 1637 4wtx (A) 1572 1650 37.00 0.0013 0.82 0.509159 -1.12
2992 3481 3l5h (A) 94 577 24.00 0.00000054 1 0.0999941 1.61
3398 3493 4u3h (A) 9 100 42.00 0.000045 1 0.474696 -1.07
3399 3493 2crz (A) 8 101 36.00 0.0059 1 0.564485 -1.47
3402 3487 1f6f (B) 105 196 37.00 0.28 0.78 0.424582 -0.91

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_171353)

Species Accession Gene Product
Brugia malayi Bm1_53510   myotactin form B
Loa Loa (eye worm) LOAG_02364   myotactin form A
Onchocerca volvulus OVOC9240  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0129 0.3276 0.9467
0.0374 0.7576 1
0.0089 0.442 0.5
0.0461 0.2819 0.999
0.0475 0.706 1
0.0116 0.6967 0.9164
0.0251 0.7407 1
0.0048 0.4176 0.4167
0.0334 0.4633 0.6856
0.0016 1 0.5
0.0446 0.3014 0.4581
0.0241 0.3619 0.7363
0.0216 0.706 1
0.0111 0.334 0.299
0.0344 0.6972 0.984
0.0165 0.3513 0.7363
0.0083 1 0.5
0.0461 0.2819 0.999
0.0336 0.3462 1
0.0223 0.4639 0
0.0446 0.3014 0.4581
0.022 0.257 0.5704
0.0156 0.6042 1
0.0313 0.5953 1
0.0446 0.3014 0.4581
0.0446 0.3014 0.4581
0.0334 0.4633 0.6856
0.0216 0.3372 0.7239
0.0048 0.432 0.432
0.012 0.7362 0.9962
0.0275 0.301 0.7543
0.0343 0.706 1
0.0178 0.5983 0.5
0.0414 0.6115 0.5
0.0223 0.4639 0
0.0009 0.5 0.5
0.0275 0.301 0.7543
0.0255 0.706 1
0.0261 0.2557 0.639
0.0178 0.5983 0.5
0.0156 0.6042 1
0.0084 0.6788 0.5
0.0089 0.4623 1
0.0251 0.7407 1
0.0338 0.7566 1
0.0403 0.706 1
0.0104 0.8804 1
0.0261 0.3873 0.7596
0.0089 0.442 0.5
0.0272 0.706 1
0.022 0.257 0.5704
0.0271 0.3613 1
0.0153 0.3082 0.7487
0.0165 0.3513 0.7363
0.0132 0.2972 0.9819
0.0034 0.2581 0
0.0275 0.301 0.7543
0.0075 0.4317 0.482
0.0114 0.6153 1
0.02 0.7068 1
0.0351 0.6072 1
0.008 0.4641 0
0.0275 0.301 0.7543
0.0488 0.3798 1
0.0448 0.7636 1
0.0312 0.5397 1
0.0446 0.3014 0.4581
0.0184 0.706 1
0.017 0.2614 1
0.0255 0.2557 0.639
0.0039 0.3299 0.3895
0.0378 0.586 0.5
0.0275 0.301 0.7543
0.0155 0.3568 1
0.0241 0.3986 0.7363
0.0414 0.6115 0.5
0.0374 0.7576 1
0.0343 0.706 1
0.0167 0.3197 0.7196
0.043 0.5151 0.5
0.037 0.706 1
0.0471 0.341 1
0.0142 0.2992 0.7505
0.0258 0.3891 0.7665
0.0167 0.3197 0.7196
0.0471 0.341 1
0.0085 0.3268 0.6703
0.0378 0.586 0.5
0.0164 0.7647 0.7789
0.012 0.7362 0.9962
0.0255 0.706 1
0.0446 0.3014 0.4581
0.0084 0.6788 0.5
0.0115 0.2557 0.623
0.0446 0.3014 0.4581
0.0446 0.3014 0.4581
0.0461 0.2819 0.999
0.0266 0.2855 1
0.0461 0.2819 0.999

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier OVOC9240 (Onchocerca volvulus),
Title for this comment
Comment