pI: 8.2925 |
Length (AA): 876 |
MW (Da): 97090 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
14 | 108 | 3lb6 (A) | 7 | 112 | 35.00 | 0.31 | 0.77 | 0.882622 | -0.09 |
116 | 149 | 2m67 (A) | 10 | 43 | 24.00 | 0.45 | 0.01 | 0.109489 | 3.19 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128482)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G23550 | Got1/Sft2-like vescicle transport protein |
Arabidopsis thaliana | AT5G24170 | Got1/Sft2-like vescicle transport protein family |
Caenorhabditis elegans | CELE_F27D4.7 | Protein F27D4.7 |
Dictyostelium discoideum | DDB_G0291055 | hypothetical protein |
Drosophila melanogaster | Dmel_CG5104 | CG5104 gene product from transcript CG5104-RB |
Echinococcus granulosus | EgrG_000167600 | Vesicle transport protein SFT2B |
Entamoeba histolytica | EHI_000640 | hypothetical protein, conserved |
Entamoeba histolytica | EHI_200980 | hypothetical protein, conserved |
Entamoeba histolytica | EHI_188010 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_000167600 | Vesicle transport protein SFT2B |
Homo sapiens | 375035 | SFT2 domain containing 2 |
Homo sapiens | 113402 | SFT2 domain containing 1 |
Leishmania braziliensis | LbrM.03.0830 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_050810.1 | Got1/Sft2-like family, putative |
Leishmania donovani | LdBPK_030900.1 | Got1/Sft2-like family, putative |
Leishmania infantum | LinJ.03.0900 | hypothetical protein, conserved |
Leishmania infantum | LinJ.05.0810 | hypothetical protein, conserved |
Leishmania major | LmjF.05.0810 | hypothetical protein, conserved |
Leishmania major | LmjF.03.0920 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.03.0920 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.05.0810 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_00785 | hypothetical protein |
Mus musculus | ENSMUSG00000040848 | SFT2 domain containing 2 |
Mus musculus | ENSMUSG00000073468 | SFT2 domain containing 1 |
Neospora caninum | NCLIV_021350 | SFT2 domain containing 1, related |
Oryza sativa | 4329697 | Os02g0564500 |
Onchocerca volvulus | OVOC317 |
|
Schistosoma japonicum | Sjp_0092870 | Vesicle transport protein SFT2B, putative |
Schistosoma mansoni | Smp_002100 | hypothetical protein |
Schmidtea mediterranea | mk4.009401.00 | |
Schmidtea mediterranea | mk4.004674.01 | |
Schmidtea mediterranea | mk4.002743.03 | |
Trypanosoma brucei gambiense | Tbg972.11.12310 | hypothetical protein, conserved |
Trypanosoma brucei gambiense | Tbg972.7.8310 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.7.7060 | Got1/Sft2-like family, putative |
Trypanosoma brucei | Tb927.11.10980 | Got1/Sft2-like family, putative |
Trypanosoma congolense | TcIL3000.11.11700 | Got1/Sft2-like family, putative |
Trypanosoma congolense | TcIL3000_7_5740 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.508181.149 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.503971.30 | Got1/Sft2-like family, putative |
Trypanosoma cruzi | TcCLB.508269.20 | Got1/Sft2-like family, putative |
Trypanosoma cruzi | TcCLB.510617.10 | Got1/Sft2-like family, putative |
Trypanosoma cruzi | TcCLB.506789.300 | Got1/Sft2-like family, putative |
Toxoplasma gondii | TGME49_203700 | SFT2 family protein |
Trichomonas vaginalis | TVAG_390730 | Vesicle transport protein SFT2A, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.2770 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.2770 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.2770 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.2770 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.7.7060 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.7060 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.7060 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.7.7060 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_203700 | Toxoplasma gondii | Probably non-essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Bos taurus | Cholesterol esterase | 597 aa | 27.7% | 495 aa | Compounds | References |
Laodelphax striatella | Acetylcholinesterase | 426 aa | 27.3% | 381 aa | Compounds | References |
Musca domestica | Acetylcholinesterase | 692 aa | 22.8% | 646 aa | Compounds | References |
Oryctolagus cuniculus | Acyl coenzyme A:cholesterol acyltransferase | 565 aa | 26.3% | 579 aa | Compounds | References |
Electrophorus electricus | Acetylcholinesterase | 633 aa | 25.3% | 648 aa | Compounds | References |
Equus caballus | Butyrylcholinesterase | 602 aa | 27.1% | 587 aa | Compounds | References |
Nephotettix cincticeps | Ace-orthologous acetylcholinesterase | 677 aa | 26.9% | 621 aa | Compounds | References |
Rattus norvegicus | Acetylcholinesterase | 614 aa | 27.0% | 581 aa | Compounds | References |
Rattus norvegicus | Liver carboxylesterase B-1 | 561 aa | 25.0% | 600 aa | Compounds | References |
Loxostege sticticalis | Carboxylesterase | 615 aa | 24.0% | 541 aa | Compounds | References |
Rattus norvegicus | Butyrylcholinesterase | 597 aa | 26.8% | 585 aa | Compounds | References |
Sus scrofa | Carboxylesterase | 566 aa | 26.9% | 535 aa | Compounds | References |
Equus caballus | Cholinesterase | 574 aa | 27.1% | 586 aa | Compounds | References |
Torpedo californica | Acetylcholinesterase | 586 aa | 25.1% | 562 aa | Compounds | References |
Bos taurus | Acetylcholinesterase | 613 aa | 26.0% | 565 aa | Compounds | References |