Detailed view for OVOC2221

Basic information

TDR Targets ID: 993302
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 6.9065 | Length (AA): 265 | MW (Da): 30481 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13417  
PF14497  

Gene Ontology

Mouse over links to read term descriptions.
GO:0015035   protein disulfide oxidoreductase activity  
GO:0009055   electron carrier activity  
GO:0045454   cell redox homeostasis  

Metabolic Pathways

Arachidonic acid metabolism (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
77 347 1z9h (A) 100 370 38.00 0 1 1.25254 -0.96
303 351 5f07 (A) 158 207 22.00 0.13 0.68 0.46348 -0.78
303 353 5a4u (A) 162 212 22.00 0.078 0.58 0.462944 -0.62
305 352 4f0b (A) 174 219 28.00 0.000012 0.19 0.402748 -0.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130341)

Species Accession Gene Product
Arabidopsis thaliana AT5G42150   Glutathione S-transferase family protein
Brugia malayi Bm1_53785   hypothetical protein
Caenorhabditis elegans CELE_R11A8.5   Protein R11A8.5
Drosophila melanogaster Dmel_CG4086   Suppressor of ref(2)P sterility
Homo sapiens ENSG00000148334   prostaglandin E synthase 2
Leishmania braziliensis LbrM.14.1670   glutathione-S-transferase/glutaredoxin, putative
Leishmania donovani LdBPK_141580.1   glutathione-S-transferase/glutaredoxin,putative
Leishmania infantum LinJ.14.1580   glutathione-S-transferase/glutaredoxin, putative
Leishmania major LmjF.14.1480   glutathione-S-transferase/glutaredoxin, putative
Leishmania mexicana LmxM.14.1480   glutathione-S-transferase/glutaredoxin, putative
Loa Loa (eye worm) LOAG_05032   hypothetical protein
Mus musculus 96979   prostaglandin E synthase 2
Neospora caninum NCLIV_019890   hypothetical protein
Oryza sativa 4335293   Os04g0244400
Onchocerca volvulus OVOC2221  
Schmidtea mediterranea mk4.001144.01  
Trypanosoma brucei gambiense Tbg972.7.3850   glutathione-S-transferase/glutaredoxin, putative
Trypanosoma brucei Tb927.7.3500   Prostaglandin E synthase
Trypanosoma congolense TcIL3000_7_2720   glutathione-S-transferase/glutaredoxin, putative
Trypanosoma cruzi TcCLB.506443.70   glutathione-S-transferase/glutaredoxin, putative
Trypanosoma cruzi TcCLB.508265.10   glutathione-S-transferase/glutaredoxin, putative
Toxoplasma gondii TGME49_304660   prostaglandin-E synthase

Essentiality

OVOC2221 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.3500 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.3500 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.3500 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.7.3500 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_304660 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens prostaglandin E synthase 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0822 0.5 0.5
0.0541 0.6959 1
0.0973 1 1
0.2648 0.7754 0.5
0.2156 0.2642 1
0.0992 1 0.5
0.0163 1 1
0.3034 0.5569 1
0.1527 1 1
0.1383 1 0.5
0.4062 1 1
0.4365 1 1
0.181979 1 0.5
0.0289 0.5 0.5
0.1463 1 0.5
0.2156 0.2642 1
0.237 0.5896 1
0.1783 1 0.5
0.2339 1 1
0.1155 1 0.5
0.6386 1 1
0.2375 1 0.5
0.1241 0.5541 0.5
0.0163 0.2709 1
0.1177 0.5956 1
0.2611 1 1
0.1272 1 1
0.5067 1 0.5
0.2331 1 1
0.2472 1 0.5
0.0158 0.3647 1
0.3328 1 1
0.2472 1 0.5
0.1428 0.5 0.5
0.4365 1 1
0.2354 0.5015 1
0.3328 1 1
0.0402 0.3716 1
0.0158 0.3647 1
0.0158 0.3647 1
0.3488 1 0.5
0.1805 0.4612 0.5
0.2354 0.5015 1
0.3328 1 1
0.2277 0.5988 1
0.0297 1 0.5
0.2156 0.2642 1
0.0721 0.5 0.5
0.4572 1 0.5
0.0155 0.3052 0.4973
0.0158 0.3647 1
0.4365 1 1
0.0163 0.3953 1
0.054 0.5 0.5
0.155 0.7808 0.5
0.2041 1 0.5
0.2125 1 0.5
0.0139 0.2877 0.5493
0.2181 0.5 0.5
0.3328 1 1
0.304 1 0.5
0.1248 1 1
0.2745 1 1
0.3573 1 1
0.1276 1 0.5
0.0145 0.546 1
0.1161 1 0.5
0.5067 1 0.5
0.2703 0.8272 1
0.0152 0.2668 0.4164
0.027 1 1
0.1556 1 1
0.0278 0.3922 0.5
0.0131 1 1
0.1222 1 0.5
0.4165 1 0.5
0.3328 1 1
0.169 1 1
0.2866 0.5 0.5
0.0133 0.7723 0.5
0.0552 0.5 0.5
0.4062 1 1
0.0816 1 1
0.0158 0.3647 1
0.0163 0.2629 0.2589
0.0623 0.5 0.5
0.3421 1 0.5
0.0816 1 1
0.0158 0.3647 1
0.3328 1 1
0.013 0.7648 1
0.3328 1 1
0.3431 1 1
0.0997 1 1
0.0689 1 0.5
0.0155 0.3052 0.4973
0.0399 0.3356 1
0.0217347 0.281958 0.5
0.3856 1 1
0.1537 1 1
0.169 1 1
0.3431 1 1
0.2614 0.5 0.5
0.1025 0.5949 1
0.0163 1 1
0.0552 0.5 0.5
0.1924 0.5 0.5
0.238 1 1
0.1136 0.5 0.5
0.155 0.7808 0.5
0.0435 1 1
0.2514 0.6076 0.5
0.3852 1 0.5
0.2339 1 1
0.3328 1 1
0.316 1 0.5
0.247 0.6261 1
0.1527 1 1
0.1783 1 0.5
0.0432 1 0.5
0.2745 1 1
0.2614 0.5 0.5
0.0408 0.4078 1
0.2735 1 0.5
0.2866 0.5 0.5
0.0696 1 0.5
0.169 1 1
0.2648 0.7754 0.5
0.0138 0.2725 1
0.3328 1 1
0.3856 1 1
0.4581 1 1
0.1406 0.5 0.5
0.169 1 1
0.0808 0.6719 1
0.0138 0.4989 1
0.2498 1 1
0.1406 0.5 0.5
0.0133 1 1
0.2478 1 0.5
0.0808 0.6719 1
0.2156 0.2642 1
0.0467 0.4976 1
0.0860912 0.756738 0.5
0.0541 0.6959 1
0.0155 0.3052 0.4973
0.304 1 0.5
0.0563 1 1
0.2745 1 1
0.1284 1 1
0.4307 1 1
0.0163 0.5 0.5
0.4222 1 1
0.1136 0.5 0.5
0.3614 1 0.5
0.0289 0.5 0.5
0.1698 1 1
0.0145 0.546 1
0.0421723 1 0.5
0.1463 1 0.5
0.2745 1 1
0.0399 0.3356 1
0.2786 1 0.5
0.0554 0.6244 1
0.0992 1 0.5
0.0277 0.3062 1
0.2043 1 0.5
0.1421 1 0.5
0.3039 0.5 0.5
0.2459 0.5 0.5
0.0135 0.3359 0.6719
0.0464 0.5415 1
0.0398 0.8031 1
0.1698 1 1
0.2277 0.5988 1
0.0267 0.3818 0.527
0.3328 1 1
0.1831 1 1
0.145613 1 0.5
0.169 1 1
0.1924 0.5 0.5
0.2745 1 1
0.0604 1 1
0.013 0.5061 1
0.1496 1 1
0.3614 1 0.5
0.4015 1 0.5
0.0537 1 0.5
0.227275 1 0.5
0.2277 0.5988 1
0.0715 1 0.5
0.0822 0.5 0.5
0.141 1 1
0.0288 1 1
0.1994 0.492 0.5
0.247 0.6261 1
0.1488 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier OVOC2221 (Onchocerca volvulus),
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