Detailed view for OVOC65

Basic information

TDR Targets ID: 993388
Onchocerca volvulus, Small membrane protein related homolog
Source Database / ID:  Wormbase Parasite  

pI: 6.7628 | Length (AA): 664 | MW (Da): 76068 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05255  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
53 123 5cxv (A) 60 128 35.00 0.069 0.09 0.646967 0.76

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130414)

Species Accession Gene Product
Arabidopsis thaliana AT1G36980   hypothetical protein
Brugia malayi Bm1_30440   Small membrane protein
Caenorhabditis elegans CELE_Y74C10AL.2   Protein Y74C10AL.2
Dictyostelium discoideum DDB_G0281983   TMEM50 family protein
Drosophila melanogaster Dmel_CG15012   CG15012 gene product from transcript CG15012-RC
Echinococcus granulosus EgrG_000881800   transmembrane protein 50B
Echinococcus multilocularis EmuJ_000881800   transmembrane protein 50B
Homo sapiens ENSG00000142188   transmembrane protein 50B
Homo sapiens ENSG00000183726   transmembrane protein 50A
Loa Loa (eye worm) LOAG_09441   hypothetical protein
Mus musculus ENSMUSG00000022964   transmembrane protein 50B
Mus musculus ENSMUSG00000028822   transmembrane protein 50A
Oryza sativa 4347235   Os09g0453000
Oryza sativa 4329713   Os02g0566900
Onchocerca volvulus OVOC65   Small membrane protein related homolog
Schistosoma japonicum Sjp_0200170   Transmembrane protein 50A, putative
Schistosoma mansoni Smp_041830   small membrane protein related
Schmidtea mediterranea mk4.005226.00   Small membrane protein related
Trichomonas vaginalis TVAG_226570   conserved hypothetical protein
Trichomonas vaginalis TVAG_237740   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Xenopus laevis Aurora kinase B-B 368 aa 30.6% 330 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 21.6% 324 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 24.8% 303 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 28.4% 264 aa Compounds References
Patiria pectinifera Cdc2 300 aa 24.7% 299 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 30.1% 309 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 42.0% 312 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 23.9% 301 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 42.0% 312 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 41.8% 306 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC65 (Onchocerca volvulus), Small membrane protein related homolog
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