Detailed view for OVOC2150

Basic information

TDR Targets ID: 993509
Onchocerca volvulus, High affinity copper uptake protein 1 homolog
Source Database / ID:  Wormbase Parasite  

pI: 6.8339 | Length (AA): 696 | MW (Da): 78081 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 12

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04145  

Gene Ontology

Mouse over links to read term descriptions.
GO:0035434   GO:copper ion transmembrane transport  

GO:0016021   integral to membrane  
GO:0005375   copper ion transmembrane transporter activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 72 2lpc (A) 129 185 32.00 0.24 0.01 0.345838 0.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128847)

Species Accession Gene Product
Arabidopsis thaliana AT5G59040   copper transporter 3
Arabidopsis thaliana AT3G46900   copper transporter 2
Arabidopsis thaliana AT2G26975   copper transporter 6
Arabidopsis thaliana AT5G59030   copper transporter 1
Brugia malayi Bm1_34425   Ctr copper transporter family protein
Candida albicans CaO19.4720   similar to S. cerevisiae CTR2 (YHR175W) putative low-affinity copper transport protein
Candida albicans CaO19.72   similar to S. cerevisiae CTR2 (YHR175W) putative low-affinity copper transport protein
Candida albicans CaO19.12183   similar to S. cerevisiae CTR2 (YHR175W) putative low-affinity copper transport protein
Caenorhabditis elegans CELE_F27C1.2   Protein F27C1.2, isoform B
Dictyostelium discoideum DDB_G0285545   hypothetical protein
Drosophila melanogaster Dmel_CG15551   Copper transporter 1C
Drosophila melanogaster Dmel_CG3977   Copper transporter 1A
Echinococcus granulosus EgrG_000124300   CTR1 high affinity copper uptake protein 1
Echinococcus multilocularis EmuJ_000124300   CTR1, high affinity copper uptake protein 1
Homo sapiens ENSG00000136868   solute carrier family 31 (copper transporter), member 1
Loa Loa (eye worm) LOAG_01304   ctr copper transporter
Loa Loa (eye worm) LOAG_06035   hypothetical protein
Mus musculus ENSMUSG00000066150   solute carrier family 31, member 1
Oryza sativa 9269583   Os04g0415600
Oryza sativa 4338846   Os05g0424700
Oryza sativa 4324611   Os01g0770800
Oryza sativa 9268111   Os03g0370800
Oryza sativa 4324610   Os01g0770700
Onchocerca volvulus OVOC2150   High affinity copper uptake protein 1 homolog
Saccharomyces cerevisiae YHR175W   Ctr2p
Saccharomyces cerevisiae YLR411W   Ctr3p
Schistosoma japonicum Sjp_0203770   High affinity copper uptake protein 1, putative
Schistosoma mansoni Smp_048230   high-affinity copper uptake protein
Schmidtea mediterranea mk4.023389.00  
Schmidtea mediterranea mk4.010999.00  
Schmidtea mediterranea mk4.001518.02  
Schmidtea mediterranea mk4.000596.00  
Schmidtea mediterranea mk4.000596.01  

Essentiality

OVOC2150 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F27C1.2 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus GABA transporter 1 599 aa 42.2% 564 aa Compounds References
Macaca fascicularis Dopamine transporter 620 aa 45.2% 600 aa Compounds References
Rattus norvegicus Dopamine transporter 619 aa 44.2% 599 aa Compounds References
Rattus norvegicus Glycine transporter 1 638 aa 41.5% 578 aa Compounds References
Macaca mulatta Transporter 620 aa 45.2% 600 aa Compounds References
Rattus norvegicus GABA transporter 614 aa 40.2% 552 aa Compounds References
Rattus norvegicus Serotonin transporter 630 aa 47.1% 629 aa Compounds References
Macaca mulatta Serotonin transporter 630 aa 50.1% 569 aa Compounds References
Bos taurus Sodium- and chloride-dependent glycine transporter 1 638 aa 41.7% 578 aa Compounds References
Rattus norvegicus Creatine transporter 635 aa 41.0% 578 aa Compounds References
Rattus norvegicus Norepinephrine transporter 597 aa 47.4% 551 aa Compounds References
Rattus norvegicus Transporter 617 aa 46.2% 573 aa Compounds References
Bos taurus Dopamine transporter 693 aa 44.4% 602 aa Compounds References
Rattus norvegicus GABA transporter 2 602 aa 40.8% 576 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier OVOC2150 (Onchocerca volvulus), High affinity copper uptake protein 1 homolog
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