pI: 6.2019 |
Length (AA): 619 |
MW (Da): 70909 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
15 | 212 | 4z8n (A) | 217 | 421 | 16.00 | 0 | 0.07 | 0.383796 | -0.23 |
67 | 184 | 4are (A) | 388 | 502 | 28.00 | 0.55 | 0.16 | 0.328768 | 0.23 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_131500)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_29420 | hypothetical protein |
Caenorhabditis elegans | CELE_ZK328.4 | Protein ZK328.4 |
Cryptosporidium hominis | Chro.70027 | hypothetical protein |
Cryptosporidium parvum | cgd7_140 | SprT family metallopeptidase |
Dictyostelium discoideum | DDB_G0288129 | hypothetical protein |
Drosophila melanogaster | Dmel_CG14814 | CG14814 gene product from transcript CG14814-RD |
Echinococcus granulosus | EgrG_001034810 | acidic repeat-containing protein |
Echinococcus multilocularis | EmuJ_001034810 | acidic repeat-containing protein |
Homo sapiens | ENSG00000147174 | acidic repeat containing |
Loa Loa (eye worm) | LOAG_04258 | hypothetical protein |
Onchocerca volvulus | OVOC233 | Putative nuclear protein |
Schistosoma japonicum | Sjp_0213990 | Acidic repeat-containing protein, putative |
Schistosoma mansoni | Smp_167880 | nuclear protein |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Sus scrofa | Carboxylesterase | 566 aa | 32.0% | 540 aa | Compounds | References |
Rattus norvegicus | Liver carboxylesterase B-1 | 561 aa | 32.0% | 544 aa | Compounds | References |
Bos taurus | Cholesterol esterase | 597 aa | 30.2% | 557 aa | Compounds | References |
Torpedo californica | Acetylcholinesterase | 586 aa | 40.7% | 551 aa | Compounds | References |
Equus caballus | Cholinesterase | 574 aa | 40.9% | 572 aa | Compounds | References |
Equus caballus | Butyrylcholinesterase | 602 aa | 41.4% | 573 aa | Compounds | References |
Bos taurus | Acetylcholinesterase | 613 aa | 41.6% | 572 aa | Compounds | References |
Oryctolagus cuniculus | Acyl coenzyme A:cholesterol acyltransferase | 565 aa | 32.4% | 549 aa | Compounds | References |
Rattus norvegicus | Acetylcholinesterase | 614 aa | 40.7% | 577 aa | Compounds | References |
Chilo suppressalis | Esterase | 503 aa | 30.8% | 520 aa | Compounds | References |
Rattus norvegicus | Butyrylcholinesterase | 597 aa | 40.6% | 581 aa | Compounds | References |