Detailed view for OVOC9279

Basic information

TDR Targets ID: 993802
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 4.894 | Length (AA): 234 | MW (Da): 27460 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 4

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00018  
PF00241  

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0005515   protein binding  
GO:0003779   actin binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 143 1x67 (A) 8 144 39.00 0 1 0.739667 -0.61
187 289 5hmo (A) 814 911 27.00 0.22 0.01 0.554456 -0.96
358 414 2csi (A) 3 66 39.00 0 0.65 0.327392 0.36
364 414 5xgg (A) 4 52 47.00 0.000049 1 0.67294 -0.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129996)

Species Accession Gene Product
Brugia malayi Bm1_10605   Variant SH3 domain containing protein
Brugia malayi Bm1_20225   hypothetical protein
Candida albicans CaO19.10214   similar to S. cerevisiae ABP1 (YCR088W) actin binding protein
Candida albicans CaO19.2699   similar to S. cerevisiae ABP1 (YCR088W) actin binding protein
Caenorhabditis elegans CELE_K08E3.4   Protein K08E3.4
Dictyostelium discoideum DDB_G0273517   actin binding protein E
Dictyostelium discoideum DDB_G0273447   actin binding protein E
Drosophila melanogaster Dmel_CG10083   Actin binding protein 1
Entamoeba histolytica EHI_054800   hypothetical protein
Homo sapiens ENSG00000136279   drebrin-like
Loa Loa (eye worm) LOAG_06729   variant SH3 domain-containing protein
Mus musculus ENSMUSG00000020476   drebrin-like
Onchocerca volvulus OVOC9279  
Saccharomyces cerevisiae YCR088W   Abp1p
Schistosoma japonicum Sjp_0214000   Drebrin-like protein, putative
Schistosoma mansoni Smp_070090   hematopoietic lineage cell specific protein

Essentiality

OVOC9279 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
YCR088W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0137 0.3036 0.7524
0.0378 0.315 0.9706
0.00394418 0.278418 0.965482
0.0061 1 1
0.0351989 0.270507 0.96674
0.0064 0.3347 0.6798
0.0322685 0.273741 0.966487
0.0336199 0.276589 0.966847
0.0039 0.2713 0
0.0027 0.3179 0.6312
0.0048 0.3625 0.7044
0.0065 0.3464 0.3133
0.0027 0.3179 0.6312
0.00394418 0.278418 0.965482
0.0029 0.4037 0.9783
0.0282 0.283 0.7523
0.0068 0.2794 0
0.0282 0.283 0.7523
0.0048 0.281 0
0.0029 0.4037 0.9783
0.0075 0.2576 0.5925
0.0137 0.2846 0.968
0.0065 0.3464 0.3133
0.0039 0.2713 0
0.0059 0.3 0

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier OVOC9279 (Onchocerca volvulus),
Title for this comment
Comment