Detailed view for OVOC5186

Basic information

TDR Targets ID: 993896
Onchocerca volvulus, Huntingtin homolog

Source Database / ID:  Wormbase Parasite  

pI: 8.5171 | Length (AA): 378 | MW (Da): 43496 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005488   binding  

Metabolic Pathways

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 148 5cwj (A) 8 156 11.00 0.02 0.42 0.313957 -1.32
35 175 4g3a (A) 64 200 12.00 0.042 0.64 0.309608 -1.08
63 812 4xri (A) 7 707 14.00 0.00000000024 1 0.285057 0.71
98 1109 1u6g (C) 4 1098 12.00 0 0.94 0.392841 0.99
184 1140 1z3h (B) 5 932 13.00 0 0.71 0.341306 0.78
558 1184 3ea5 (D) 198 814 12.00 0 1 0.303097 0.38
629 1592 1z3h (A) 6 951 12.00 0 1 0.364047 0.77
757 1769 4hzk (A) 76 1063 9.00 0 1 0.417233 0.74
1038 1801 3nc1 (A) 59 867 12.00 0 0.9 0.324739 0.89
1278 1536 5f0k (A) 182 420 31.00 0.89 0.16 0.0713096 0.86

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132837)

Species Accession Gene Product
Brugia malayi Bm1_40225   hypothetical protein
Dictyostelium discoideum DDB_G0272344   Huntingtin family protein
Drosophila melanogaster Dmel_CG9995   huntingtin
Homo sapiens ENSG00000197386   huntingtin
Loa Loa (eye worm) LOAG_04057   hypothetical protein
Loa Loa (eye worm) LOAG_00299   hypothetical protein
Mus musculus ENSMUSG00000029104   huntingtin
Onchocerca volvulus OVOC5186   Huntingtin homolog
Onchocerca volvulus OVOC5168   Huntingtin homolog
Schmidtea mediterranea mk4.007035.00  
Schmidtea mediterranea mk4.001550.02  
Schmidtea mediterranea mk4.002087.06  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens huntingtin Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0128 0.3346 0.4494
0.0136 0.3312 1
0.0148 0.5832 1
0.0123 1 0.5
0.014 0.2738 0.2765
0.0489 0.583 0.6703
0.0148 0.2913 0.8858
0.0128 0.4166 0.5
0.0372 0.4337 1
0.0257 0.5167 0.4928
0.0119 0.4981 1
0.0124 0.4829 1
0.0253 0.717 1
0.0265 0.3295 1
0.0148 0.7262 1
0.0388 0.3836 0.3836
0.0408 0.3855 1
0.0148 0.6884 0.5
0.0136 0.3954 1
0.0128 0.3282 0.5
0.0123 0.4744 0.4552
0.0148 0.3684 0.4552
0.0378 0.5303 0.7655
0.0125 0.2709 0.2686
0.0119 0.2634 1
0.0148 0.2924 1
0.0129 0.2807 0.7054
0.0133 0.3061 0.8216
0.0148 0.3304 1
0.0128 0.5332 0
0.0141 0.2553 0.7726
0.0256 0.2963 1
0.0119 0.4966 1
0.0148 0.2851 0.2827
0.0148 0.4928 0.4928
0.0261 0.3555 1
0.0136 0.3852 1
0.0148 0.7942 0.5
0.0148 0.2769 0.6392
0.0251 0.2719 0.9006
0.0124 0.4932 0.4932
0.0128 0.6171 1
0.0254 0.309 1
0.0238 0.2865 1
0.0148 0.3882 0.4818
0.0148 1 0.5
0.013 0.2664 0.4355
0.0131 0.3961 0.5161
0.0148 0.4382 1
0.0275 0.7251 1
0.0884 0.5496 1
0.0143 0.3946 1
0.0121 0.3774 0.3653
0.0536 0.3568 0.6869
0.0144 0.3641 0.4784
0.0143 1 0.5
0.0251 0.3082 0.4691
0.0122 0.5114 1
0.0087 0.439 0.5072
0.0127 0.376 1
0.014 1 1
0.1816 0.571 1
0.0142 0.3895 1
0.0128 0.3945 1
0.0142 0.4583 0.5591
0.0148 0.4378 0.4957
0.0148 0.3278 1
0.0371 0.2852 1
0.0136 0.2935 0.6665
0.039 0.4587 1
0.0265 0.3781 0.9507
0.0882 0.3417 1
0.026 0.3518 1
0.0129 0.5056 1
0.0148 0.3381 0.6273
0.0363 0.3203 0.735
0.0128 0.2807 0.4932
0.0148 0.2544 0.4943
0.0124 0.3515 0.5
0.0121 0.709 1
0.027 0.2913 1
0.0121 0.4588 0.5
0.0239 0.3502 1
0.0148 1 0.5
0.0142 0.3365 0.4546
0.0124 0.2555 0.5104
0.0148 0.3288 0.471
0.0127 1 0.5
0.0148 0.4485 1
0.0123 0.3632 0.4559
0.012 0.3243 1
0.0253 1 1
0.0126 0.3369 1
0.0383 0.3056 0.3013
0.0148 1 0.5
0.0128 0.3111 0.2809
0.0125 0.3577 0.6843
0.0249 0.3553 1
0.0148 0.498 1
0.0121 1 0.5
0.0243 0.2586 0.3253
0.0109 0.308 1
0.0292 0.2826 1
0.0148 0.3262 0.4476
0.0144 0.2546 0.6449
0.0148 0.346 0.688
0.0145 0.3919 1
0.0401 0.4662 1
0.0148 0.4915 1
0.0256 0.2827 1
0.0142 0.2935 1
0.0279 0.982 1
0.0119 0.2882 1
0.0137 0.7669 1
0.0267 0.2992 0.5978
0.0117 0.2641 0.4494
0.0253 0.3883 1
0.0131 0.4311 1
0.0139 0.3595 0.5787
0.014 1 1
0.0148 0.3799 0.4805
0.0143 0.3079 1
0.0502 0.3067 1
0.0138 0.3671 0.4143
0.0148 1 0.5
0.0269 0.2563 1
0.0251 0.7107 1
0.0279 0.564 1
0.0148 1 0.5
0.0255 0.2526 0.9922
0.0133 0.3103 1
0.0133 0.3149 0.4921
0.0148 0.2828 0.2828
0.0136 0.2637 0.5
0.0252 0.276 1
0.0148 0.4825 1
0.0148 0.3062 0.4539
0.013 0.4732 0.471
0.0148 0.5157 0.6669
0.0142 0.456 1
0.0257 0.2953 1
0.0148 1 1
0.0125 0.3788 0.5
0.0265 0.354 1
0.013 0.3766 0.4431
0.0527 0.5665 1
0.0148 1 0.5
0.024 0.2898 0.4866
0.0148 0.3222 0
0.0124 0.3337 0.5253
0.0264 0.5263 0.5263
0.0246 0.2548 1
0.0266 0.2624 0.8722
0.0122 0.29 0.3703
0.0133 0.2526 0.7542
0.0249 0.2771 0.3311
0.0148 0.5921 1
0.0148 0.2907 1
0.0125 0.8628 1
0.0118 0.2708 0.3694
0.0135 0.4139 0.5
0.039 1 1
0.014 0.3035 1
0.0248 0.4853 0.4975
0.0148 1 1
0.0264 0.9493 1
0.0098 0.4779 1
0.0244 0.2617 0.2504
0.0261 0.718 1
0.0148 0.4505 0.4494
0.0142 0.5899 1
0.0148 0.4828 0.4476
0.012 0.2953 0.6706
0.0119 0.4512 1
0.0132 0.6294 1
0.0125 0.2547 0.5
0.0148 0.3465 0.4476
0.0148 0.3364 0.663
0.0147 0.4505 0.7034
0.0121 0.3584 0.4493
0.027 0.2938 0.5171
0.0119 1 0.5
0.0126 0.2846 1
0.0148 0.8408 0.5
0.012 0.2518 0.6207
0.0243 0.2913 0.9893
0.0133 0.5111 1
0.0148 0.489 1
0.0134 1 0.5
0.0278 0.301 0.378
0.0374 0.2583 0.7859
0.0148 1 1
0.0249 0.3019 1
0.0121 1 1
0.0148 0.2807 0.2532
0.0148 0.7406 1
0.0121 0.378 1
0.0247 0.5147 1
0.0148 0.3301 0.382
0.0123 0.605 1
0.026 0.5238 1
0.0121 0.6479 1
0.0134 0.7962 0.5
0.0245 0.2643 0.5117
0.0122 0.2756 0.5304
0.0141 0.4751 1
0.0143 0.3378 1
0.0278 0.3007 0.9691
0.0123 1 0.5
0.0148 1 0.5
0.0122 0.5057 0.5103
0.0254 0.3193 1
0.0144 0.3505 1
0.0129 0.289 1
0.0253 0.3637 0.5737
0.012 0.2863 1
0.0128 0.2773 1
0.0256 0.3186 0.3078
0.0255 0.2792 1
0.0409 0.528 0.5
0.0241 0.2956 1
0.0142 0.3376 0
0.0363 0.4026 1
0.0123 0.2525 1
0.0406 0.4182 1
0.0121 1 0.5
0.0251 0.3039 0.3447
0.0148 1 1
0.0397 0.3051 0.7192
0.0268 0.2833 1
0.0235 0.2916 0.5526
0.0144 0.5098 0.5128
0.0149 1 0.5
0.0252 0.2604 1
0.0252 0.3673 1
0.0119 0.2832 1
0.0144 0.2636 0.2404
0.0127 0.3934 1
0.0245 0.4898 1
0.0142 0.3962 0.5
0.0148 0.3946 1
0.0247 0.2727 0.5431
0.0132 0.5136 0.4985
0.0133 0.4825 1
0.0118 1 1
0.0122 0.4892 1
0.0242 0.2741 0.6358
0.0255 0.2799 1
0.0124 0.4294 0.3584
0.0148 0.6483 0.5
0.0123 0.3153 0.5474
0.0262 0.4698 1
0.0148 0.3143 1
0.0253 0.2787 0.4938
0.0107 0.5098 0.5098
0.0241 0.4969 0.6396
0.0142 0.3014 0.565
0.0122 0.4821 0.4789
0.011 0.2555 0.641
0.0367 0.3001 0.2997
0.0148 0.3103 0.7674
0.012 0.2903 0.423
0.0119 0.2686 1
0.0129 0.3425 0.7396
0.0125 0.2847 0.8466
0.0421 0.2707 0.4143
0.0254 0.7571 0.5
0.0276 0.313 1
0.0147 0.2535 1
0.0127 0.3204 0.7184
0.0271 0.3024 1
0.0392 0.3752 1
0.0141 0.5025 1
0.0245 0.269 1
0.0127 0.2998 1
0.0119 1 0.5
0.0253 0.3138 0.3078
0.0148 0.2923 1
0.0122 0.3924 1
0.012 1 1
0.0133 0.6936 1
0.0372 0.4582 1
0.0148 0.3361 1
0.0148 0.3765 0.537
0.0148 1 1
0.0143 1 1
0.0123 0.3033 0.8614
0.0121 0.4464 0.4274
0.0148 0.5111 1
0.0259 0.2626 0.9656
0.0505 0.3087 1
0.0121 0.4373 0.4073
0.0146 0.3354 0.7106
0.013 0.3047 0.8037
0.0132 1 0.5
0.0251 0.3621 1
0.0119 1 0.5
0.0136 0.6775 1
0.0135 0.6479 1
0.0148 1 0.5
0.0362 0.4508 0.4663
0.0148 0.3261 1
0.0248 0.5103 1
0.0271 0.2667 1
0.0148 0.4957 1
0.0148 0.2924 1
0.024 0.2947 1
0.0121 0.3304 1
0.0123 0.2956 0.5
0.0124 1 0.5
0.0131 0.338 0.3709
0.0263 0.5088 1
0.0142 0.3851 1
0.0275 0.2682 1
0.0126 0.2643 1
0.0119 0.3792 0.5
0.0148 0.5324 0.5204
0.0275 1 0.5
0.0246 0.436 1
0.0244 0.2765 1
0.0126 0.319 0.4629
0.0275 0.2826 1
0.0119 0.3344 1
0.0252 0.3604 1
0.0367 0.2579 1
0.0258 0.299 1
0.0134 1 1
0.0148 0.7119 1
0.0256 0.2574 1
0.0148 0.488 0.4622
0.0268 0.2664 1
0.0121 0.2952 1
0.0119 0.2824 0.6514
0.0105 0.2603 0.3907
0.0134 0.3292 1
0.0162 0.3655 0.8746
0.026 0.8718 0.5
0.0122 0.3154 0.3516
0.0386 0.4476 1
0.0126 0.5033 1
0.0148 0.3852 1
0.0132 0.2871 0.7505
0.0126 0.7879 0.7643
0.0268 0.3175 1
0.012 0.4888 0.5
0.0243 0.2918 1
0.0119 0.6075 0.5
0.0261 0.2755 0.3776
0.014 0.2843 1
0.0266 0.3547 0.5263
0.0261 0.2755 0.3776
0.0525 0.2843 0.7687
0.0241 0.3421 0.5
0.0148 0.5335 1
0.0147 0.5026 0.4539
0.0124 0.2962 0.5072
0.025 0.2585 1
0.0148 1 0.5
0.0258 0.3026 0.4662
0.0254 0.5162 0.539
0.028 0.5272 1
0.0086 0.6898 1
0.0148 1 0.5
0.0132 1 0.5
0.0122 0.3213 0.664
0.0141 0.318 0.3177
0.0126 0.364 0.4568
0.0148 0.5 0.5
0.0121 0.4046 1
0.025 0.2819 1
0.0249 0.2962 0.7901
0.0097 0.5061 0.4957
0.0136 0.3898 1
0.0148 0.4847 1
0.0126 0.2583 1
0.0124 0.2583 1
0.0265 0.7045 0.5
0.0137 0.313 0.4599
0.0121 0.3058 1
0.025 0.2864 1
0.0119 0.7936 1
0.0245 0.2678 1
0.0134 0.4914 0.4661
0.0496 0.3446 1
0.0137 0.3386 1
0.0124 0.2996 0.5
0.0128 0.3518 0.4572
0.0148 0.2917 1
0.0148 0.2888 1
0.026 0.2861 1
0.0136 1 0.5
0.012 0.497 1
0.0148 1 0.5
0.0402 0.4548 1
0.0388 0.2733 1
0.0148 0.318 0.6128
0.014 0.2853 0.7662
0.0148 0.2531 0.5004
0.0147 0.2799 1
0.0243 0.2958 1
0.0381 0.4083 1
0.0148 0.3341 1
0.0125 0.4772 1
0.0121 0.2889 0.6773
0.0148 0.3946 1
0.0148 0.4665 0.6178
0.0131 0.3647 0.5327
0.0148 0.2793 0.5782
0.0246 0.2959 1
0.0128 0.3446 1
0.0148 0.2847 0.7995
0.0141 1 0.5
0.0148 0.2881 0.5
0.0148 0.4966 1
0.013 0.377 1
0.0246 0.2776 1
0.0135 0.3146 0.4994
0.0258 0.634 1
0.0137 0.2924 1
0.0148 0.6856 0
0.0125 0.3636 0.402
0.0091 0.404 0.4476
0.0148 0.2669 1
0.0134 0.3338 1
0.027 0.392 1
0.0249 0.2935 1
0.0125 0.2942 1
0.026 0.2863 1
0.0103 1 0.5
0.0123 0.4513 0.4513
0.0148 1 0.5
0.0122 0.2505 1
0.0112 0.432 1
0.0149 0.8272 1
0.0257 0.2948 0.8835
0.0131 0.3196 0.3549
0.0124 0.3205 1
0.0144 0.5225 0
0.0137 0.2663 0.3925
0.0394 0.2553 1
0.0266 0.2662 1
0.0133 0.6479 1
0.038 0.465 1
0.0123 0.3696 0.6423
0.0267 0.3202 0.5334
0.0196 0.2882 1
0.0119 0.6878 1
0.0126 0.4459 0.4928
0.0142 0.4909 0.5
0.0127 0.4686 0.5
0.0247 0.3332 0.4963
0.0137 0.4394 0.4476
0.0125 0.3976 1
0.0148 0.2523 1
0.0133 0.2711 0.4806
0.0254 0.2574 0.4535
0.0125 1 0.5
0.0124 0.2757 0.3314
0.0121 0.2842 0.7981
0.0144 0.2995 1
0.0123 0.3834 1
0.012 0.5261 1
0.0264 0.2617 0.2612
0.0137 1 0.5
0.0148 0.2583 0.2297
0.0255 0.3117 1
0.0669 0.3847 1
0.0259 0.2868 1
0.0148 0.2512 1
0.0138 0.3677 1
0.0142 0.5525 1
0.0122 0.3769 0.3522
0.0148 0.3485 0.5
0.0242 0.4324 1
0.0123 0.2922 1
0.0148 1 1
0.0276 0.2815 1
0.0133 0.2687 0.5539
0.0148 1 1
0.0253 0.3533 1
0.0329 0.2782 0.7627
0.0125 0.258 1
0.0124 0.2854 0.507
0.0148 0.7942 1
0.0148 1 0.5
0.0148 0.336 1
0.0148 1 1
0.0254 0.4504 1
0.0148 0.3145 0.5963
0.0138 0.3456 1
0.0125 0.5356 0.5891
0.0123 0.3447 0.6634
0.0498 0.3472 0.9179
0.0148 0.3033 0.4476
0.0123 0.4089 1
0.0119 0.3205 0.6934
0.0255 0.2521 0.5022
0.0148 0.2879 1
0.0124 0.7942 0.5
0.0119 0.6945 1
0.0247 0.2908 0.5064
0.0148 0.492 1
0.0136 0.9821 1
0.0148 0.4934 0.5
0.0121 0.4858 0.4736
0.0141 0.2706 1
0.0148 1 1
0.0148 0.4734 0.6348
0.0131 0.5094 1
0.0148 0.4166 0.5
0.0148 0.3454 0.6972
0.0241 0.2825 0.31
0.0256 0.2672 1
0.012 0.3936 0.4568
0.0148 0.7459 1
0.0263 0.2649 0.5544
0.0148 1 0.5
0.0258 0.2573 1
0.0126 0.3989 1
0.025 0.3011 1
0.0121 0.3908 1
0.0244 0.2835 1
0.0507 0.5862 1
0.0118 0.259 1
0.0136 0.4724 0.6982
0.0148 0.7144 0.5
0.0129 0.3674 1
0.012 1 0.5
0.0119 0.331 0.3926
0.0148 0.3376 0.4892
0.0243 1 1
0.0257 0.3024 0.4516
0.012 0.3489 1
0.0148 0.6812 1
0.0537 0.5674 1
0.0131 0.5174 0.812
0.0163 0.3056 1
0.0136 1 0.5
0.0264 0.2559 1
0.0133 0.3394 1
0.0267 0.3119 0.8617
0.0121 0.3195 1
0.0129 0.4536 1
0.0148 0.316 0.29
0.0124 0.6794 1
0.0148 0.5014 0.7909
0.0267 0.2987 1
0.0127 0.338 1
0.0488 0.3003 1
0.0148 1 1
0.0281 0.5012 1
0.0252 0.2806 0.8002
0.0249 0.2861 0.7038
0.0122 0.4828 0.4476
0.0133 0.2931 0.4582
0.0133 0.2924 1
0.0326 0.2708 0.4937
0.0129 0.3609 0.4376
0.0262 0.2562 0.5867
0.0148 0.4792 1
0.0148 0.5972 1
0.0124 0.3851 1
0.0131 1 0.5
0.0148 0.3705 0.3548
0.0653 0.2525 1
0.0148 0.6936 1
0.0119 0.7203 1
0.0256 0.3153 0.4883
0.0123 0.3325 0.5
0.0245 0.2849 0.6747
0.0124 0.3537 1
0.0124 0.2948 1
0.0367 0.4518 1
0.0238 0.3085 1
0.0256 0.2979 0.889
0.0241 0.7402 1
0.0278 0.2806 1
0.0241 0.5229 1
0.0242 0.2506 1
0.0127 0.4954 1
0.0144 0.4753 0.5384
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0.0127 0.2747 0.4289
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0.0121 0.3806 1