Detailed view for OVOC11650

Basic information

TDR Targets ID: 994059
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 7.9419 | Length (AA): 320 | MW (Da): 35782 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13639  

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
109 139 2mrf (A) 196 226 39.00 0.077 0.42 0.5397 0.4
113 199 5ywr (B) 141 227 60.00 0.0000000094 1 1.1773 -0.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132411)

Species Accession Gene Product
Brugia malayi Bm1_11595   zrfp1-pending-prov protein
Caenorhabditis elegans CELE_Y71F9AL.10   Protein Y71F9AL.10
Dictyostelium discoideum DDB_G0272202   C2H2-type zinc finger-containing protein
Drosophila melanogaster Dmel_CG14435   CG14435 gene product from transcript CG14435-RC
Echinococcus granulosus EgrG_000626800   Zinc finger RING type
Echinococcus multilocularis EmuJ_000626800   Zinc finger, RING type
Homo sapiens ENSG00000186187   zinc and ring finger 1, E3 ubiquitin protein ligase
Homo sapiens ENSG00000180233   zinc and ring finger 2, E3 ubiquitin protein ligase
Loa Loa (eye worm) LOAG_09553   hypothetical protein
Mus musculus ENSMUSG00000033545   zinc and ring finger 1
Mus musculus 387524   zinc and ring finger 2
Onchocerca volvulus OVOC11650  
Schmidtea mediterranea mk4.000779.02   RE59544p

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Carbonic anhydrase 3 260 aa 28.8% 257 aa Compounds References
Bos taurus Carbonic anhydrase II 260 aa 31.6% 247 aa Compounds References
Bos taurus Carbonic anhydrase IV 312 aa 23.4% 252 aa Compounds References
Stylophora pistillata Carbonic anhydrase 316 aa 26.7% 288 aa Compounds References
Rattus norvegicus Carbonic anhydrase II 260 aa 27.2% 254 aa Compounds References
Astrosclera willeyana Astrosclerin-3 292 aa 27.8% 245 aa Compounds References
Sulfurihydrogenibium sp. (strain YO3AOP1) Carbonate dehydratase 246 aa 27.8% 245 aa Compounds References
Bos taurus Carbonic anhydrase 312 aa 23.4% 252 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC11650 (Onchocerca volvulus),
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