Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0227 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0227 | 0.5 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0227 | 0.5 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0227 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0227 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0227 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0227 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0227 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0227 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0227 | 0.5 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0227 | 0.5 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0227 | 0.5 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0227 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0227 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0227 | 0.5 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0227 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1.5 ug ml-1 | Antibacterial activity against kanamycin-resistant Escherichia coli AG100A expressing aminoglycosides resistant APH(3')-1 enzyme by double-microdilution method | ChEMBL. | 19301822 |
MIC (functional) | = 6 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 by double-microdilution method | ChEMBL. | 19301822 |
MIC (functional) | = 24 ug ml-1 | Antibacterial activity against kanamycin-resistant Escherichia coli AG100B expressing aminoglycosides resistant APH(3')-1 enzyme by double-microdilution method | ChEMBL. | 19301822 |
MIC (functional) | = 24 ug ml-1 | Antibacterial activity against Escherichia coli R477-100 by double-microdilution method | ChEMBL. | 19301822 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.