Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0409 | 0.1745 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0221 | 0.0794 | 0.3624 |
Chlamydia trachomatis | sulfate transporter | 0.0065 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0409 | 0.1745 | 1 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0115 | 0.0254 | 0.0254 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0409 | 0.1745 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0115 | 0.0254 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0409 | 0.1745 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.0794 | 0.3624 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1937 | 0.9502 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0221 | 0.0794 | 0.3624 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0115 | 0.0254 | 0.0537 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.047 | 0.2055 | 0.1948 |
Leishmania major | carbonic anhydrase-like protein | 0.0409 | 0.1745 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0221 | 0.0794 | 0.3966 |
Echinococcus multilocularis | carbonic anhydrase | 0.0221 | 0.0794 | 0.3624 |
Echinococcus multilocularis | carbonic anhydrase | 0.0221 | 0.0794 | 0.3624 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0115 | 0.0254 | 0.0449 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0098 | 0.0169 | 0.0169 |
Onchocerca volvulus | Putative sulfate transporter | 0.0407 | 0.1735 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0221 | 0.0794 | 0.3624 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0409 | 0.1745 | 1 |
Plasmodium vivax | sulfate transporter, putative | 0.0065 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.0794 | 0.3624 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0409 | 0.1745 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0115 | 0.0254 | 0.0537 |
Echinococcus granulosus | carbonic anhydrase | 0.0221 | 0.0794 | 0.3624 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0221 | 0.0794 | 0.3966 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0221 | 0.0794 | 0.3966 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0115 | 0.0254 | 0.1455 |
Toxoplasma gondii | hypothetical protein | 0.0221 | 0.0794 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0221 | 0.0794 | 0.3624 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0409 | 0.1745 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0221 | 0.0794 | 0.3624 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0409 | 0.1745 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0221 | 0.0794 | 0.3966 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0221 | 0.0794 | 0.3966 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0115 | 0.0254 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0409 | 0.1745 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2036 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0221 | 0.0794 | 0.3624 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0221 | 0.0794 | 0.3624 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0115 | 0.0254 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0409 | 0.1745 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0221 | 0.0794 | 0.3624 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2036 | 1 | 1 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0115 | 0.0254 | 0.0537 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.047 | 0.2055 | 1 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0115 | 0.0254 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0221 | 0.0794 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0221 | 0.0794 | 0.3624 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0568 | 0.2553 | 0.2486 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.0794 | 0.3624 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0115 | 0.0254 | 0.1455 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0409 | 0.1745 | 1 |
Onchocerca volvulus | 0.0407 | 0.1735 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.32 uM | Cytotoxicity against human A549 cells by SRB assay | ChEMBL. | 18653334 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 18653334 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.