Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphorylase, glycogen, liver | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0082 | 0.4407 | 0.4407 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0082 | 0.4407 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.4407 | 0.4407 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.013 | 1 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 0.4407 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 0.4407 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0082 | 0.4407 | 0.4407 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 1 | 0.5 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0054 | 0.1117 | 0.1117 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 1 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0082 | 0.4407 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0056 | 0.1405 | 0.1405 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.013 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.013 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 1 | 1 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0056 | 0.1405 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.013 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 1 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0082 | 0.4407 | 0.5 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 0.4407 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 1 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0082 | 0.4407 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 0.4407 | 0.5 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0082 | 0.4407 | 0.5 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0054 | 0.1117 | 0.1117 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 1 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0082 | 0.4407 | 0.4407 |
Brugia malayi | Probable ClpP-like protease | 0.0082 | 0.4407 | 0.4407 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.013 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.013 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.27 uM | Inhibition of human glycogen phosphorylase alpha | ChEMBL. | 18554908 |
IC50 (binding) | = 2.5 uM | Inhibition of human glycogen phosphorylase alpha in HepG2 cells assessed as inhibition of forskolin-induced glycogenolysis after 60 mins | ChEMBL. | 18554908 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.