Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Ets-domain containing protein | 0.0084 | 0.0666 | 0.0666 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0624 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.4941 | 0.4941 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0215 | 0.0215 |
Trichomonas vaginalis | chromobox protein, putative | 0.008 | 0.0611 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.008 | 0.0611 | 0.0611 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0215 | 0.0215 |
Schistosoma mansoni | gabp alpha | 0.0084 | 0.0666 | 0.0183 |
Leishmania major | ferric reductase, putative | 0.0293 | 0.428 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0215 | 0.0215 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0293 | 0.428 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0084 | 0.0665 | 0.5 |
Brugia malayi | Ets-domain containing protein | 0.0084 | 0.0666 | 0.0666 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0456 | 0.0456 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0215 | 0.0215 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.008 | 0.0611 | 0.0611 |
Brugia malayi | Fli-1 protein | 0.0254 | 0.3607 | 0.3607 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0084 | 0.0666 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0049 | 0.0059 | 0.0969 |
Treponema pallidum | hypothetical protein | 0.0084 | 0.0665 | 0.5 |
Loa Loa (eye worm) | fli-1 protein | 0.0254 | 0.3607 | 0.3607 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0084 | 0.0666 | 1 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0084 | 0.0666 | 0.0666 |
Trichomonas vaginalis | chromobox protein, putative | 0.0049 | 0.0059 | 0.0969 |
Schistosoma mansoni | ets-related | 0.0254 | 0.3607 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.008 | 0.0611 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0624 | 1 | 1 |
Trypanosoma brucei | ferric reductase transmembrane protein, putative | 0.0293 | 0.428 | 0.5 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0293 | 0.428 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0049 | 0.0059 | 0.0059 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of c-Met at 10 uM by ELISA | ChEMBL. | 18610999 | |
Inhibition (binding) | = 0 % | Inhibition of c-Src at 10 uM by ELISA | ChEMBL. | 18610999 |
Inhibition (binding) | = 3.1 % | Inhibition of FGFR2 at 10 uM by ELISA | ChEMBL. | 18610999 |
Inhibition (binding) | = 3.6 % | Inhibition of EGFR at 10 uM by ELISA | ChEMBL. | 18610999 |
Inhibition (binding) | = 9.4 % | Inhibition of cKit at 10 uM by ELISA | ChEMBL. | 18610999 |
Inhibition (binding) | = 9.9 % | Inhibition of KDR at 10 uM by ELISA | ChEMBL. | 18610999 |
Inhibition (binding) | = 27.9 % | Inhibition of FGFR1 at 10 uM by ELISA | ChEMBL. | 18610999 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.