Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0144 | 0.3841 | 1 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0118 | 0.2766 | 1 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0121 | 0.2893 | 0.5857 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0118 | 0.2766 | 0.5 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0121 | 0.2893 | 0.5152 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0054 | 0.0173 | 0.0309 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0295 | 1 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0054 | 0.0163 | 0.033 |
Echinococcus multilocularis | geminin | 0.0171 | 0.494 | 1 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0121 | 0.2893 | 0.5857 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 1 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0295 | 1 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0121 | 0.2893 | 0.5857 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0169 | 0.4852 | 0.4852 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0075 | 0.1036 | 0.1845 |
Trypanosoma brucei | unspecified product | 0.0054 | 0.0173 | 0.0309 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.494 | 0.8797 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 1 | 1 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0121 | 0.2893 | 0.5152 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0118 | 0.2766 | 0.5 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0121 | 0.2893 | 0.5857 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0054 | 0.0173 | 0.0309 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0121 | 0.2893 | 0.5857 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0295 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated cation channel | 0.0121 | 0.2893 | 0.5152 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.5615 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 1 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0144 | 0.3841 | 1 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0121 | 0.2893 | 0.56 |
Leishmania major | ribonuclease H1, putative | 0.005 | 0 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0187 | 0.5615 | 1 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0075 | 0.1036 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0054 | 0.0173 | 0.0309 |
Toxoplasma gondii | ribonuclease HI protein | 0.005 | 0 | 0.5 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0054 | 0.0163 | 0.033 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0144 | 0.3841 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.5166 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0121 | 0.2893 | 0.5857 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.494 | 0.8797 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 1 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0121 | 0.2893 | 0.5857 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 1 | 1 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0118 | 0.2766 | 0.2766 |
Brugia malayi | Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog | 0.0176 | 0.5166 | 1 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0054 | 0.0173 | 0.0309 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 1 | 1 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0121 | 0.2893 | 0.5857 |
Echinococcus granulosus | geminin | 0.0171 | 0.494 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 1 | 1 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0118 | 0.2766 | 0.5 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0121 | 0.2893 | 0.5857 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0121 | 0.2893 | 0.5857 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.