Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Gallus gallus | Neuronal acetylcholine receptor subunit alpha-4 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 0 % | Toxicity in Swiss Webster mouse at >36 mg/kg, ip | ChEMBL. | 18570364 |
IC50 (binding) | = 500 nM | Displacement of [3H]nicotine from chick alpha4beta2 nAChR | ChEMBL. | 18570364 |
LD50 (ADMET) | > 36 mg kg-1 | Toxicity in ip dosed Swiss Webster mouse | ChEMBL. | 18570364 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.