Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.297 | 0.297 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.553 | 0.553 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0089 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0089 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.553 | 0.553 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0089 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0089 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.8617 | 0.8617 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.297 | 0.297 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.553 | 0.553 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0089 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.553 | 0.553 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.297 | 0.297 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of recombinant human AKT1 using GSK3 (amino acids 14 to 27) as substrate | ChEMBL. | 21982797 |
IC50 (binding) | > 100 uM | Inhibition of recombinant human ALK | ChEMBL. | 21982797 |
IC50 (binding) | > 100 uM | Inhibition of recombinant human ARK5 | ChEMBL. | 21982797 |
IC50 (binding) | > 100 uM | Inhibition of recombinant human Aurora-B using tetra(LRRWLSG) as substrate | ChEMBL. | 21982797 |
IC50 (binding) | > 100 uM | Inhibition of recombinant human AXL | ChEMBL. | 21982797 |
IC50 (binding) | > 100 uM | Inhibition of recombinant human FAK using poly(Glu,Tyr)4:1 as substrate | ChEMBL. | 21982797 |
IC50 (binding) | > 100 uM | Inhibition of recombinant human IGF1-R using poly(Glu,Tyr)4:1 as substrate | ChEMBL. | 21982797 |
IC50 (binding) | > 100 uM | Inhibition of wild type human MEK1 | ChEMBL. | 21982797 |
IC50 (binding) | > 100 uM | Inhibition of wild type human MET using poly(Ala,Glu,Lys,Tyr) as substrate | ChEMBL. | 21982797 |
IC50 (binding) | > 100 uM | Inhibition of recombinant human NEK2 | ChEMBL. | 21982797 |
IC50 (binding) | > 100 uM | Inhibition of recombinant human NEK6 | ChEMBL. | 21982797 |
IC50 (binding) | > 100 uM | Inhibition of recombinant human PIM1 | ChEMBL. | 21982797 |
IC50 (binding) | > 100 uM | Inhibition of recombinant human PLK1 using casein as substrate | ChEMBL. | 21982797 |
IC50 (binding) | > 100 uM | Inhibition of recombinant human PRK1 | ChEMBL. | 21982797 |
IC50 (binding) | > 100 uM | Inhibition of recombinant human SRC using poly(Glu,Tyr)4:1 as substrate | ChEMBL. | 21982797 |
IC50 (binding) | > 100 uM | Inhibition of recombinant human VEGF-R2 using poly(Glu,Tyr)4:1 as substrate | ChEMBL. | 21982797 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.